Protein Alignment KLHL18 and klhl40b

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_001410734.2
• Gene: klhl40b / 795319
• ZFINID: ZDB-GENE-060227-1
• Length: 618
• Species: Danio rerio
• Alignment Length: 574
• Identity: 145/574 - (25%)
• Similarity: 244/574 - (42%)
• Gaps: 70/574 - (12%)

  Fly    38 LCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSALESLINYVYSG 102
            :.|..||::|:.|..||:||||...||.|.|.:.:.||:.:||.:::  :||..:..::.|:|:.
Zfish    32 MVDCVLKIKDKEFPCHRLVLAACSSYFRAFFKSGVEESKQREIVLED--VEPGVMGIILKYLYTS 94

  Fly   103 QVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLIDAADKYID 167
            .:.:..||||::...::.||:.::...|.|||..|....|.|.|......:.|.:|..:|..:..
Zfish    95 NINVTEQNVQDIFALSNMLQIPSIFTVCVSFLQKRLSLSNCLAIFRLGLMLDCPRLAISARNFAC 159

  Fly   168 QNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRL 232
            :.|..:::.||||.|...:|..::..|.|||.||:.:|||.:|||.:.::.|....|.:|..:||
Zfish   160 ERFQFITRDEEFLQLTPSELAAVLASDSLNVETEQDVFEALIKWVGHDQENRIGDLPDLLDCIRL 224

  Fly   233 PLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHL--MPERR---------------------- 273
            .|:...:....|.:.|.:.|:.:....|...||.|.  :||.:
Zfish   225 RLVPRDYFVKNVEKHEWLSSNPEITKKLQLVKDAHAGKLPELKKTKNKKSPSEEGQKKGDEEEVE 289

  Fly   274 ----------GLLQSFRTRQRSGEFFTGQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMM 328
                      |:|..   ..|.|.|....|:.:...||..        |||......:....:.:
Zfish   290 EEEEQEERLPGILND---NLRFGMFLRELIFLINDSASVA--------YDPTGNDCYVASVSTQI 343

  Fly   329 -RSRVGVAVLNGKLYAFGGFNGTERLSTVEVY------DPRKNKWSQGCAMLCKRSAVGVAALDD 386
             ::...:.....:::..||....|:....::|      ||..:.|.....:...|...|:...::
Zfish   344 PKNHCSLVTKENQIFVAGGLFFDEQSKDEQIYSYFLQFDPASSDWMGMPPIPSPRFLFGMGEAEN 408

  Fly   387 CIYVCGG---YDGVTSLNTVEVYYPKSNTWKTVAQMMKYRSAG-GVTQLNGYVYALGGH-DGLSI 446
            .|:|.||   .:|...||||.||..:...| ..:..:.|...| ||...|..:|.:||. :....
Zfish   409 FIFVIGGREMKEGENILNTVMVYDRQFLKW-AESDPLPYLVYGHGVVSHNEMIYVIGGKGENKEC 472

  Fly   447 FDSVERYDQAEDVWVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVT 511
            .:.|..||.....|...:|:...|...||......|||..|...:....|.|.||.:|:.|....
Zfish   473 LNRVCAYDIKTHQWKDFAPLNTARSLFGVTIHKNNIYVVAGVTDSGLTGSAEVYDIKTNKWSEFV 537

  Fly   512 PMNCKRSRVALAANMGKLWAIGGY-----DGESNLSTVEV-----YDPETDKWT 555
            .....||.::|.:..|.|:|:||:     :...:|..:|:     ||.....|:
Zfish   538 EFPQDRSSLSLVSVSGVLYAVGGFAMFPKEDSDDLMPLEMNDIWRYDESERTWS 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	33/98 (34%)
		PHA03098	36..510	CDD:222983	132/517 (26%)
		KELCH repeat	329..372	CDD:276965	7/48 (15%)
		KELCH repeat	376..417	CDD:276965	14/43 (33%)
		KELCH repeat	423..466	CDD:276965	11/44 (25%)
		KELCH repeat	470..514	CDD:276965	13/43 (30%)
		Kelch_1	517..560	CDD:396078	13/49 (27%)
		KELCH repeat	517..560	CDD:276965	13/49 (27%)
klhl40b	NP_001410734.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	264..297		2/32 (6%)
		Kelch 1	356..408		9/51 (18%)
		Kelch 2	409..458		16/49 (33%)
		Kelch 3	459..506		11/46 (24%)
		Kelch 4	508..553		13/44 (30%)
		Kelch 5	555..608		9/37 (24%)