Protein Alignment KLHL18 and kbtbd7

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: XP_073768686.1
• Gene: kbtbd7 / 794299
• ZFINID: ZDB-GENE-070912-204
• Length: 621
• Species: Danio rerio
• Alignment Length: 613
• Identity: 155/613 - (25%)
• Similarity: 238/613 - (38%)
• Gaps: 158/613 - (25%)

  Fly    17 KHDKLFGESFPLFKEIRRMGKLCDVTLKVEDQT--------------FSAHRVVLAATIPYFYAM 67
            |..|||.:|          ..|.|||::||..|              |...|.:|||..|||.:|
Zfish    24 KEMKLFYDS----------QLLVDVTIEVEPDTETAERSVSSGAGKVFQCSRNILAAASPYFKSM 78

  Fly    68 FTNNMAESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACAS 132
            ||..:.||..:::|:.:  ::..::..:|:|.|:|:|.|...|||.|...|:.|||..:|.|||:
Zfish    79 FTGGLYESTQRKVTIHD--VDADSMAVIIDYCYTGKVTITESNVQRLYAAANMLQLEYIRQACAN 141

  Fly   133 FLISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQS-EEFLALDCEQLLELMRRDEL 196
            |:..|....|..||..|||:....:|...|..:|.:||.::..| :|...||..|:.|::..|.|
Zfish   142 FMTRRLDLSNCAGILKFADTFDNLELKREAQAFIAKNFVQLGASVKELCELDQRQIKEILMLDSL 206

  Fly   197 NVRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLD 261
            :|..|..:....::|::....:.||...|||..||..|.|.:   |||..:.| :|....:..|.
Zfish   207 DVDCERKVCSFAVQWIESNLHENSEDALQVLKCVRWSLFSEK---DRVYLDGL-KSKPFIKKYLS 267

  Fly   262 EAKDFHLMPERRGL--LQSFRTRQRSGEFFTGQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQ 324
            ...| ....|:.|.  |.....:||.|:.....:..:      |.....:..|||..      |.
Zfish   268 NILD-GACSEQSGTISLSVHAAKQRIGKSAKEMVLFL------GRPNQPIMCYDPYV------ED 319

  Fly   325 MSMMRSRVGVAVLNGKLYAFGGFNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIY 389
            :..|.|                              |..|..||.    .|||.:      :...
Zfish   320 IYSMAS------------------------------PVINLTSQN----FKRSPM------ETFL 344

  Fly   390 VCGGYDGVTSLNTVE----------VYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGL 444
            ||     .|..|.:.          ||.|..:.|:.:|:.:..|....:..|||::|.|||.|.:
Zfish   345 VC-----TTPENNLYLASQLSKHFWVYNPLLDCWQELAERLLGRMQSYIGYLNGHLYILGGRDPV 404

  Fly   445 S--IFDSVERYDQAEDVWVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTW 507
            |  ....||.|....:.||.::|:.:...::.|.|:|.::||..       .|.:.||:|:.:.|
Zfish   405 SDARLKEVECYSIQRNQWVFVAPLPHSLGKMQVVTVNERLYVVN-------KRRMLCYEPKKNHW 462

  Fly   508 KLVTPMNCKRSR------------------VALAAN--MGKLWAIGGYDGES------------- 539
              :...:.|||:                  |..|.|  .|:...||....:|
Zfish   463 --LQRASLKRSKLHNACVFQEQIICLCDIPVVKAYNPVRGEWRRIGDIPIDSCALNYQVVQHSSK 525

  Fly   540 -------------NLSTVEVYDPETDKW 554
                         |...:..|||..|.|
Zfish   526 LLLLTIAVVHHNKNRLVIHEYDPTRDSW 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	44/130 (34%)
		PHA03098	36..510	CDD:222983	134/502 (27%)
		KELCH repeat	329..372	CDD:276965	5/42 (12%)
		KELCH repeat	376..417	CDD:276965	10/50 (20%)
		KELCH repeat	423..466	CDD:276965	15/44 (34%)
		KELCH repeat	470..514	CDD:276965	10/43 (23%)
		Kelch_1	517..560	CDD:396078	15/84 (18%)
		KELCH repeat	517..560	CDD:276965	15/84 (18%)
kbtbd7	XP_073768686.1	None