DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KLHL18 and klhl24

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_001072337.1	Gene:	klhl24 / 779790	XenbaseID:	XB-GENE-1000313	Length:	600	Species:	Xenopus tropicalis

Alignment Length:	551	Identity:	183/551 - (33%)
Similarity:	284/551 - (51%)	Gaps:	28/551 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSAL 92
            :|.|.|......||.:.||.:.|..||.:|:|...||.|||.|:..|||  |:.::.:.|...|:
Frog    55 VFNEFRENRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESR--EMLVEINGIFAEAM 117

  Fly    93 ESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQ 157
            :..:.|||:|:|:|..:|||.|...:|..|:|.:|||||.||..:..|.|.|||:.|||:...:.
Frog   118 DCFLQYVYTGRVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQHFADTHSLKT 182

  Fly   158 LIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSEL 222
            |......:..|.|..|.|.||||.|...:|::.:..|||.|..||::|||.|:||.:..|.|..:
Frog   183 LFTKCKSFAQQAFEDVVQHEEFLELGKAELIDYVSTDELVVSKEELVFEAVMRWVYHHVDVRRPM 247

  Fly   223 FPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLLQSFRTRQRSGE 287
            ..::|..||||||.|.:....|..:::|:::..|..||.||:.:|::...   :.|.|||.|...
Frog   248 LQELLTHVRLPLLHPNYFVQTVEVDQIIQNAPDCYQLLHEARRYHILGNE---MMSPRTRPRRST 309

  Fly   288 FFTGQIYAVGGLASTGE-SVSTVEIYDPLTKKWK-MGEQMSMMRSRVGVAVLNGKLYAFGGFNGT 350
            .::..|..|||....|. ::...|.|||:|.:|| :.:.....:|...|..|...:...||
Frog   310 GYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGG---- 370

  Fly   351 ERLST--VEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTSLNTVEVYYPKSNTW 413
             |:::  |.:|:.:.|.|.:..::...|....:|.|...:||.|||||...|::||.|...||.|
Frog   371 -RINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVESYDSFSNRW 434

  Fly   414 KTVAQMMKYRSAGGVTQLNGYVYAL-GGHDGLSIFDSVERYDQAEDVW-VKMSPMLNRRCRLGVA 476
            ..||.:.:..|:..|....|.::.: ||.|..:..|.|:.||...:.| ::.|..:.:|| :...
Frog   435 TDVAPLKEAVSSPAVASCVGKLFVVGGGPDDNTCSDKVQCYDPDNNTWLLRASIPIAKRC-ITAV 498

  Fly   477 TLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKRSRVALAANMGKLWAIG--GYDGES 539
            :||..|||.||     ..:::.||||..|.|..|.....::....::...||::.:|  |.:||:
Frog   499 SLNNLIYVAGG-----LTKAIYCYDPVEDYWIHVQNTFTRQENCGMSVCNGKIFILGGRGENGEA 558

  Fly   540 NLSTVEVYDPETDKWT---FMPPMCAHSGGV 567
            . .|:..|||.|...|   .||...::.|.|
Frog   559 T-DTILCYDPATSIITGVAAMPRPVSYHGCV 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	43/105 (41%)
		PHA03098	36..510	CDD:222983	163/479 (34%)
		BACK	143..245	CDD:285009	39/101 (39%)
		Kelch	292..339	CDD:128874	15/48 (31%)
		KELCH repeat	329..372	CDD:276965	10/44 (23%)
		Kelch	340..386	CDD:128874	10/47 (21%)
		KELCH repeat	376..417	CDD:276965	17/40 (43%)
		Kelch	387..433	CDD:128874	18/45 (40%)
		KELCH repeat	423..466	CDD:276965	12/44 (27%)
		Kelch	435..480	CDD:128874	12/46 (26%)
		Kelch_1	469..514	CDD:279660	16/44 (36%)
		KELCH repeat	470..514	CDD:276965	16/43 (37%)
		Kelch_1	517..560	CDD:279660	14/47 (30%)
		KELCH repeat	517..560	CDD:276965	14/47 (30%)
klhl24	NP_001072337.1	BTB_POZ_KLHL24_KRIP6	48..168	CDD:349562	45/114 (39%)
		PHA03098	59..566	CDD:222983	172/523 (33%)
		KELCH repeat	354..393	CDD:276965	10/43 (23%)
		KELCH repeat	397..441	CDD:276965	19/43 (44%)
		KELCH repeat	444..489	CDD:276965	12/44 (27%)
		KELCH repeat	492..529	CDD:276965	16/42 (38%)
		KELCH repeat	536..578	CDD:276965	12/42 (29%)
		Kelch	545..591	CDD:128874	15/45 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910