Protein Alignment KLHL18 and Klhl2

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: XP_017168500.1
• Gene: Klhl2 / 77113
• MGIID: 1924363
• Length: 626
• Species: Mus musculus
• Alignment Length: 589
• Identity: 232/589 - (39%)
• Similarity: 335/589 - (56%)
• Gaps: 43/589 - (7%)

  Fly    24 ESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIE 88
            ::|.:..|:|....|||||:..||....||||||||..|||:||||..|:|||.|.:.:||  ::
Mouse    41 KAFKVMNELRSQNLLCDVTIVAEDMEIPAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKE--VD 103

  Fly    89 PSALESLINYVYSGQVRIDNQNV---------------------------------QNLMVGASF 120
            ...|..|::|||:.::::..:||                                 |.|:..|..
Mouse   104 GWTLRMLVDYVYTAEIQVTEENVQVQCKSLHRGWKNRKESKTTSGRPSGVSYSLYEQVLLPAAGL 168

  Fly   121 LQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCE 185
            |||.:|:..|..||.|:.||.|.||||.|||...|..|::.|:.|.:|:||.|..|||||.|..|
Mouse   169 LQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIE 233

  Fly   186 QLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELI 250
            |:..|:..|:|.:.:||.:|||.:.||.:.:|.|.|...:::..||||||..::|..||..|.|:
Mouse   234 QVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALV 298

  Fly   251 RSSHQCRDLLDEAKDFHLMP-ERRGLLQSFRTRQRSGEFFTGQIYAVGGLASTGESVSTVEIYDP 314
            ::|..|:|.|.||..:||:| |:|.|::|.|||.|:.......:..|||.|.  :::.:||.||.
Mouse   299 KNSSACKDYLIEAMKYHLLPTEQRMLMKSVRTRLRTPMNLPKLMVVVGGQAP--KAIRSVECYDF 361

  Fly   315 LTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGGFNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAV 379
            ..::|....::...|.|.|:..:.|.::|.|||||:.|:.||:.|||.|::|:....|..:||.:
Mouse   362 KEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTL 426

  Fly   380 GVAALDDCIYVCGGYDGVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGL 444
            |.|.|:..:|..||:||.|.|::||.|..|||.|..||.|...||:.||..:.|.:||:||:||.
Mouse   427 GAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGA 491

  Fly   445 S--IFDSVERYDQAEDVWVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTW 507
            |  ...:||.|:...:.|..::.|..||...||..||..:|..||:.|....:|||.|||.|:.|
Mouse   492 SRQCLSTVECYNATANEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAW 556

  Fly   508 KLVTPMN-CKRSRVALAANMGKLWAIGGYDGESNLSTVEVYDPETDKWTFMPPMCAHSGGVGAGV 571
            :.|..|| |:|:....|.| |.|:.:||.||..||::||.|:|.|||||.: ..|..:|...|||
Mouse   557 RQVADMNMCRRNAGVCAVN-GLLYVVGGDDGSCNLASVEYYNPTTDKWTVV-SSCMSTGRSYAGV 619

  Fly   572 IRIE 575
            ..|:
Mouse   620 TVID 623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	49/145 (34%)
		PHA03098	36..510	CDD:222983	199/509 (39%)
		KELCH repeat	329..372	CDD:276965	18/42 (43%)
		KELCH repeat	376..417	CDD:276965	19/40 (48%)
		KELCH repeat	423..466	CDD:276965	16/44 (36%)
		KELCH repeat	470..514	CDD:276965	18/43 (42%)
		Kelch_1	517..560	CDD:396078	20/42 (48%)
		KELCH repeat	517..560	CDD:276965	20/42 (48%)
Klhl2	XP_017168500.1	BTB_POZ	35..188	CDD:453885	50/148 (34%)
		PHA03098	56..606	CDD:222983	222/554 (40%)
		BACK_KLHL2_Mayven	186..315	CDD:350587	56/128 (44%)
		KELCH repeat	376..419	CDD:276965	18/42 (43%)
		KELCH repeat	423..467	CDD:276965	21/43 (49%)
		KELCH repeat	519..563	CDD:276965	18/43 (42%)
		KELCH repeat	566..612	CDD:276965	21/47 (45%)