DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment KLHL18 and Klhl40

DIOPT Version :9

Sequence 1:NP_001262494.1 Gene:KLHL18 / 41458 FlyBaseID:FBgn0037978 Length:575 Species:Drosophila melanogaster
Sequence 2:NP_082478.1 Gene:Klhl40 / 72330 MGIID:1919580 Length:621 Species:Mus musculus


Alignment Length:641 Identity:154/641 - (24%)
Similarity:253/641 - (39%) Gaps:142/641 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 KEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMF---TNNMAESRIKEITMKESAIEPSA 91
            |::...||..|..::|.::.|..||:||||..|||.|.|   .::..|.|::|::       |..
Mouse    24 KDMLDHGKFLDCVVRVGEREFPCHRLVLAACSPYFRARFLAEPDSAGEVRLEEVS-------PDV 81

  Fly    92 LESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICR 156
            :..:::|:|:.::.:|..:||:|...|...|:.::...|.|||..|....|.|.:......:.|.
Mouse    82 VSQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLANCLAVFRLGLLLDCA 146

  Fly   157 QLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVK----YAED 217
            :|..||..:|...|..|::..:||.|..::|:.::..|.|||..||.:|||.|:|..    .|:.
Mouse   147 RLAVAARDFICARFPLVARDNDFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWASSGDAEAQA 211

  Fly   218 KRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLLQSFRTR 282
            :|....|.|..:||..||...||..||.|..|:||..:....:...||.|     .|.|.:.|.:
Mouse   212 ERQRALPTVFESVRCRLLPRAFLETRVERHPLVRSQPELLRKVQMVKDAH-----EGRLTTLRKK 271

  Fly   283 Q--------------------------------------RSGEFFTGQIYAV---GGLASTGESV 306
            :                                      |.|.|....|:.:   |.:|      
Mouse   272 KKEKGEQTARAKEANQGTEDTKAEDDEERVLPGILNDTLRFGMFLQDLIFMISEEGAVA------ 330

  Fly   307 STVEIYDPLTKKWKMGEQMSMM-RSRVGVAVLNGKLYAFGG--FNGTERLSTVEVY----DPRKN 364
                 |||...:.......:.: ::.|.:.....:::..||  :|...:...:..|    |...:
Mouse   331 -----YDPAANECYCASLSTQIPKNHVSLVTKENQVFVAGGLFYNEDNKEDPMSAYFLQFDHLDS 390

  Fly   365 KWSQGCAMLCKRSAVGVAALDDCIYVCGG---YDGVTSLNTVEVYYPKSNTWKTVAQMMKYRSAG 426
            :|.....:...|...|:....:.|||.||   .|...||::|..|...|..|             
Mouse   391 EWLGMPPLPSPRCLFGLGEALNAIYVVGGRELKDSEDSLDSVLCYDRLSFKW------------- 442

  Fly   427 GVTQLNGYVYALGGHDGLSIFDSV--------ER--------YDQAEDVWVKMSPMLNRRCRLGV 475
              .:.:...||:.||..||..|.|        :|        ||..:..|.:::||...|...|.
Mouse   443 --GESDPLPYAVYGHTVLSHMDLVYVIGGKGKDRKCLNKMCVYDPKKFEWKELAPMQTARSLFGA 505

  Fly   476 ATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKRSRVALAANMGKLWAIGGY----- 535
            ...:|:|:|..|........|.|.|....:.|........:||.::|.:..|.|:|:||:     
Mouse   506 TVHDGRIFVAAGVTDTGLTSSSEVYSIADNKWTSFEAFPQERSSLSLVSLAGTLYALGGFATLET 570

  Fly   536 -DGE---SNLSTVEVYDPETDKW-------------TFMPPMCAHSGGVGAGVIRI 574
             .||   :.|:.:..|:.:..||             ||:|        |...|:|:
Mouse   571 ESGELVPTELNDIWRYNEDEKKWEGVLREIAYAAGATFLP--------VRLNVLRL 618

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KLHL18NP_001262494.1 BTB 29..135 CDD:279045 32/107 (30%)
PHA03098 36..510 CDD:222983 133/547 (24%)
BACK 143..245 CDD:285009 34/105 (32%)
Kelch 292..339 CDD:128874 7/50 (14%)
KELCH repeat 329..372 CDD:276965 7/48 (15%)
Kelch 340..386 CDD:128874 8/51 (16%)
KELCH repeat 376..417 CDD:276965 14/43 (33%)
Kelch 387..433 CDD:128874 12/48 (25%)
KELCH repeat 423..466 CDD:276965 12/58 (21%)
Kelch 435..480 CDD:128874 16/60 (27%)
Kelch_1 469..514 CDD:279660 10/44 (23%)
KELCH repeat 470..514 CDD:276965 10/43 (23%)
Kelch_1 517..560 CDD:279660 17/64 (27%)
KELCH repeat 517..560 CDD:276965 17/64 (27%)
Klhl40NP_082478.1 BTB 23..125 CDD:279045 32/107 (30%)
PHA03098 47..594 CDD:222983 141/584 (24%)
BACK 133..239 CDD:285009 34/105 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 265..298 2/32 (6%)
KELCH repeat 351..398 CDD:276965 7/46 (15%)
Kelch 1. /evidence=ECO:0000255 360..412 8/51 (16%)
KELCH repeat 402..448 CDD:276965 14/60 (23%)
Kelch 2. /evidence=ECO:0000255 413..462 18/63 (29%)
Kelch 414..462 CDD:128874 18/62 (29%)
KELCH repeat 452..497 CDD:276965 11/44 (25%)
Kelch 463..510 CDD:128874 9/46 (20%)
Kelch 3. /evidence=ECO:0000255 463..510 9/46 (20%)
Kelch_1 499..538 CDD:279660 9/38 (24%)
KELCH repeat 500..545 CDD:276965 10/44 (23%)
Kelch 4. /evidence=ECO:0000255 512..557 10/44 (23%)
Kelch_1 547..594 CDD:279660 13/46 (28%)
KELCH repeat 547..594 CDD:276965 13/46 (28%)
Kelch 5. /evidence=ECO:0000255 559..613 14/61 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4441
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X9
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.810

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