Protein Alignment KLHL18 and Klhl35

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: XP_006508283.1
• Gene: Klhl35 / 72184
• MGIID: 1919434
• Length: 579
• Species: Mus musculus
• Alignment Length: 541
• Identity: 148/541 - (27%)
• Similarity: 236/541 - (43%)
• Gaps: 91/541 - (16%)

  Fly    33 RRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEP-------- 89
            ||.|.|.||.|:...:.|..||..|:|...:|..:|.....|        :.:|:.|
Mouse    34 RRSGTLTDVVLRAGGRDFPCHRAALSAASAHFRGLFAAGRPE--------RAAAVVPVGPETPGT 90

  Fly    90 -SALESLINYVYSGQVRIDNQN-VQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADS 152
             :||..:::|||...||:..:: ...::..|..|.::.:|:|||.||..|....|.|.:|..|.:
Mouse    91 AAALAVVLDYVYGAGVRLRAEDEAAAVLALAERLGVAGLREACARFLEGRLRAANSLALRRVAAA 155

  Fly   153 MICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAED 217
            .....|.:...:.:.|.|.:|::..:||.|..:::..|:....|.|..||.:|||.|:||::...
Mouse   156 FSLASLAERCGRVLRQAFVEVTRHADFLELAPDEVAALLADPALRVAREEAVFEAAMRWVRHDAP 220

  Fly   218 KRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLLQSFRTR 282
            .|.....::|..||||||:|.:..::|..:||:::...||.||.||:...::....|.|   |.|
Mouse   221 ARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGDCRPLLLEARACFILGREAGAL---RAR 282

  Fly   283 QRSGEFFTGQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGGF 347
            .|........|..:||.                              .|.|:.
Mouse   283 PRRFMDLAEVIVVIGGC------------------------------DRKGLL------------ 305

  Fly   348 NGTERLSTVEVYDPRKNKWS-----QGCAMLCKRSAVGVAALDDCIYVCGGYDGVTSLNTVEVYY 407
                :|...:.|.|...:|:     .|..    ||.....||.:.|||.||:     :|:.:|:.
Mouse   306 ----KLPFADAYHPESQRWTPLPSLPGYT----RSEFASCALRNDIYVSGGH-----INSRDVWM 357

  Fly   408 PKS--NTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVWVKMSPMLNRR 470
            ..|  |||..||.|.|.|....:..|.|.::|:||.|||....||||||...:.|..::|:....
Mouse   358 FSSHLNTWIKVASMHKGRWRHKMVALQGQLFAVGGFDGLRRLRSVERYDPFSNTWAAIAPLPEAV 422

  Fly   471 CRLGVATLNGKIYVCGGYCGNSFLRS--VECYDPQTDTWKLVTPMNCKRSRVALAANMGKLWAIG 533
            ....||...|::||.|| .|...:.:  |:|:||:.|.|.|.:|....:..:...:....::.:|
Mouse   423 SSAAVAPCAGQLYVIGG-AGQDGVNTDKVQCFDPKEDQWSLRSPAPFLQRCLEAVSLEDTIYVVG 486

  Fly   534 GYDGESNLSTVEVYDPETDKW 554
            |.     :|.:..|||.:|.|
Mouse   487 GL-----MSKIFTYDPGSDVW 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	32/113 (28%)
		PHA03098	36..510	CDD:222983	136/492 (28%)
		KELCH repeat	329..372	CDD:276965	7/47 (15%)
		KELCH repeat	376..417	CDD:276965	15/42 (36%)
		KELCH repeat	423..466	CDD:276965	16/42 (38%)
		KELCH repeat	470..514	CDD:276965	16/45 (36%)
		Kelch_1	517..560	CDD:396078	8/38 (21%)
		KELCH repeat	517..560	CDD:276965	8/38 (21%)
Klhl35	XP_006508283.1	BTB_POZ_KLHL35	17..148	CDD:349574	34/121 (28%)
		BACK	<171..254	CDD:475122	29/82 (35%)
		NanM	293..511	CDD:442289	70/271 (26%)
		KELCH repeat	331..371	CDD:276965	17/44 (39%)
		KELCH repeat	375..419	CDD:276965	17/43 (40%)
		KELCH repeat	422..467	CDD:276965	16/45 (36%)
		KELCH repeat	470..510	CDD:276965	8/38 (21%)