DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KLHL18 and Klhl5

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_780383.2	Gene:	Klhl5 / 71778	MGIID:	1919028	Length:	708	Species:	Mus musculus

Alignment Length:	572	Identity:	230/572 - (40%)
Similarity:	341/572 - (59%)	Gaps:	18/572 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DQYF-VYKHDKLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAE 74
            |::| ...|.:   ::|...:...|..:||||.|...|:...|||:||::...||.|||||::.|
Mouse   147 DEFFQALNHAE---QTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVRE 208

  Fly    75 SRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFH 139
            :|.:||.|:  .:||::|.|||.|.|:|::.:...|::.|:..|..||||.|.:||..||:.:.|
Mouse   209 ARQEEIKME--GVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLH 271

  Fly   140 PHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVI 204
            |.|.||||:|||:..|..|...|..|..::|.:|.:::||:.|...::.:|:..|::|:..||.|
Mouse   272 PSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETI 336

  Fly   205 FEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLM 269
            ..|.:.||::..::|.:...::||.:|||||:|||||| :....|.|...:|:.|:.||..:||:
Mouse   337 LNALLTWVRHDLEQRRKDLSRLLAYIRLPLLAPQFLAD-MENNALFRDDIECQKLIMEAMKYHLL 400

  Fly   270 PERRGLLQSFRTRQRSGEFFTGQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGV 334
            ||||.:|||.||:.|...  .|.::||||:.|| :..:::|.||..|..|.....|:..|.:.||
Mouse   401 PERRPMLQSPRTKPRKST--VGTLFAVGGMDST-KGATSIEKYDLRTNMWTPVANMNGRRLQFGV 462

  Fly   335 AVLNGKLYAFGGFNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTS 399
            |||:.|||..||.:|.:.|:|||.|:|:...||....|...|..:|||.|:..:|..||:||.:.
Mouse   463 AVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSY 527

  Fly   400 LNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVWVKMS 464
            |||||.:.|::..|..||.|...||..||..|:|.:||:||.||.|...|||.:|...:.|...:
Mouse   528 LNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCA 592

  Fly   465 PMLNRRCRLGVATLNGKIYVCGGY-CGNSFLRS-----VECYDPQTDTWKLVTPMNCKRSRVALA 523
            .|..||..:||.|.||.:|..||: ...|.|.|     ||.|||:||.|..|..|:..|..|.:.
Mouse   593 QMSKRRGGVGVTTWNGLLYAIGGHDAPTSNLTSRLSDCVERYDPKTDVWTAVASMSVSRDAVGVC 657

  Fly   524 ANMGKLWAIGGYDGESNLSTVEVYDPETDKWTFMPPMCAHSGGVGAGVIRIE 575
            ....||:|:|||||::.|:.||.|||:|::||.:.|:|.  |..||.|:.::
Mouse   658 LLGDKLYAVGGYDGQTYLNIVEAYDPQTNEWTQVAPLCL--GRAGACVVTVK 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	44/105 (42%)
		PHA03098	36..510	CDD:222983	198/479 (41%)
		BACK	143..245	CDD:285009	39/101 (39%)
		Kelch	292..339	CDD:128874	18/46 (39%)
		KELCH repeat	329..372	CDD:276965	20/42 (48%)
		Kelch	340..386	CDD:128874	20/45 (44%)
		KELCH repeat	376..417	CDD:276965	17/40 (43%)
		Kelch	387..433	CDD:128874	20/45 (44%)
		KELCH repeat	423..466	CDD:276965	18/42 (43%)
		Kelch	435..480	CDD:128874	18/44 (41%)
		Kelch_1	469..514	CDD:279660	22/50 (44%)
		KELCH repeat	470..514	CDD:276965	21/49 (43%)
		Kelch_1	517..560	CDD:279660	19/42 (45%)
		KELCH repeat	517..560	CDD:276965	19/42 (45%)
Klhl5	NP_780383.2	BTB	163..266	CDD:279045	43/104 (41%)
		PHA03098	173..695	CDD:222983	219/527 (42%)
		BACK	275..374	CDD:285009	37/98 (38%)
		Kelch	422..467	CDD:128874	18/45 (40%)
		Kelch_1	456..501	CDD:279660	20/44 (45%)
		KELCH repeat	457..500	CDD:276965	20/42 (48%)
		KELCH repeat	504..548	CDD:276965	19/43 (44%)
		Kelch	517..561	CDD:128874	20/43 (47%)
		KELCH repeat	551..594	CDD:276965	18/42 (43%)
		Kelch	562..608	CDD:128874	18/45 (40%)
		Kelch_1	597..648	CDD:279660	22/50 (44%)
		KELCH repeat	598..648	CDD:276965	21/49 (43%)
		Kelch_1	651..694	CDD:279660	19/42 (45%)
		KELCH repeat	651..694	CDD:276965	19/42 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820