DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KLHL18 and Klhl30

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_081827.1	Gene:	Klhl30 / 70788	MGIID:	1918038	Length:	581	Species:	Mus musculus

Alignment Length:	559	Identity:	157/559 - (28%)
Similarity:	243/559 - (43%)	Gaps:	99/559 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 YKHDKLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEI 80
            :..|.|.|     .:.:|.:.||.||||.|.||....||.:||...|||:|||..:..||.:..:
Mouse    15 HAQDMLEG-----LQRLRSLPKLADVTLLVGDQELPCHRSLLALNSPYFHAMFAGDFTESFLARV 74

  Fly    81 TMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLG 145
            .:::  :||:.:..|:::||:|::.|...||:.|...||.|....|:..|..:|..:....|.||
Mouse    75 ELRD--VEPAMVGQLVDFVYTGRLTITQANVEALTRSASRLNFPTVQKVCGRYLQQQLDATNCLG 137

  Fly   146 IRTFADSMICRQLIDAADK---YIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEA 207
            |..|.:.   :.|:..|.|   ::.:||..|:|.:|||.|..::|...:..|.|.|:.|:...||
Mouse   138 ICEFGEQ---QGLLGVAAKAWAFLRENFEAVAQEDEFLQLARDRLATCLASDLLQVQPEQSRLEA 199

  Fly   208 CMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPER 272
            .::||::....|:...|::|:.|.|..:....:...:|.|.||:.|..|::.|.:...    .|.
Mouse   200 LLRWVRHDPQDRAAHLPELLSLVHLDAVPRPCVQQLLATEPLIQESEACQEALSQGHS----EEL 260

  Fly   273 RGLLQSFRTRQRSGEFFTGQIYAVGGLA-----STGESVS----TVEIYDPLTKKWKMGEQMSMM 328
            .||.|..:.          .:..|||.|     ..||..|    ....|:...::|
Mouse   261 PGLPQKMQE----------VLVVVGGRALEEDEDGGEEPSHHTGNFAFYNTKARQW--------- 306

  Fly   329 RSRVGVAVLNGKLYAFGGFNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGG 393
                         .|...|             |..:||           ...:|||:..:||.||
Mouse   307 -------------MALPDF-------------PDYHKW-----------GFSLAALNSDVYVTGG 334

  Fly   394 YDG--VTSLNTVEVY-YP-KSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDS--VER 452
            ..|  ..:.:|.:.: :| |...||.||.|:|.|:....|.|||.:||:||    :..|:  |||
Mouse   335 SRGTKTDTWSTTQAWCFPLKEAIWKPVAPMLKARTNHASTALNGEIYAIGG----TALDAVEVER 395

  Fly   453 YDQAEDVWVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLV-TPMNCK 516
            ||...|.|..:.|..........|...|::|:.|.......:.:::||.|.||.|.:: :|...|
Mouse   396 YDPYTDSWAPVGPAPKYVSNFSAAGCQGRLYLVGSSACKYNMLALQCYSPVTDAWSVIASPFLPK 460

  Fly   517 -RSRVALAANMGKLWAIGGYDGESNLSTVEVYDPETDKW 554
             .|....||..|.|:.||     .|...|.||||..:.|
Mouse   461 YLSSPRCAALNGALYLIG-----DNTKKVYVYDPGANLW 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	37/105 (35%)
		PHA03098	36..510	CDD:222983	137/491 (28%)
		BACK	143..245	CDD:285009	29/104 (28%)
		Kelch	292..339	CDD:128874	9/55 (16%)
		KELCH repeat	329..372	CDD:276965	5/42 (12%)
		Kelch	340..386	CDD:128874	8/45 (18%)
		KELCH repeat	376..417	CDD:276965	13/44 (30%)
		Kelch	387..433	CDD:128874	17/49 (35%)
		KELCH repeat	423..466	CDD:276965	17/44 (39%)
		Kelch	435..480	CDD:128874	14/46 (30%)
		Kelch_1	469..514	CDD:279660	11/45 (24%)
		KELCH repeat	470..514	CDD:276965	11/44 (25%)
		Kelch_1	517..560	CDD:279660	14/38 (37%)
		KELCH repeat	517..560	CDD:276965	14/38 (37%)
Klhl30	NP_081827.1	BTB	23..127	CDD:279045	37/105 (35%)
		PHA03098	29..494	CDD:222983	152/538 (28%)
		BACK	135..237	CDD:285009	29/104 (28%)
		Kelch 1	280..327		13/92 (14%)
		KELCH repeat	319..364	CDD:276965	15/44 (34%)
		Kelch 2	328..378		17/49 (35%)
		Kelch	329..378	CDD:128874	17/48 (35%)
		Kelch_1	367..408	CDD:279660	17/44 (39%)
		KELCH repeat	368..410	CDD:276965	18/45 (40%)
		Kelch 3	379..423		14/47 (30%)
		KELCH repeat	413..455	CDD:276965	10/41 (24%)
		Kelch 4	425..472		13/46 (28%)
		KELCH repeat	462..499	CDD:276965	14/38 (37%)
		Kelch 5	474..514		10/26 (38%)
		KELCH repeat	504..551	CDD:276965
		Kelch 6	515..564
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810