Protein Alignment KLHL18 and Kbtbd3

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_081238.2
• Gene: Kbtbd3 / 69149
• MGIID: 1916399
• Length: 607
• Species: Mus musculus
• Alignment Length: 571
• Identity: 144/571 - (25%)
• Similarity: 238/571 - (41%)
• Gaps: 64/571 - (11%)

  Fly    28 LFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSAL 92
            :.:..|......|..:.::::....||.||||...:|.|||..||.|.....:|:  :.:...|:
Mouse    37 VLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTI--TNLSSKAV 99

  Fly    93 ESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQ 157
            ::.::|.|:|:.||.:.||:.....:||||:|.:..||:.|||......|.|.:.:.:||....|
Mouse   100 KAFLDYAYTGKTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCLHLLSLSDSYGSAQ 164

  Fly   158 LIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSEL 222
            |......::..:|..:.:|.:||.::...|.:.:..|||||..||::.:|.:.|:||..:.|.:.
Mouse   165 LFSHTLYFVQHHFHLLYKSSDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNLESRQKH 229

  Fly   223 FPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLLQSFRTRQRSGE 287
            .|.::..|||..||...|.|.:..||.:..|..|.|::.:|  ...:....||....|.......
Mouse   230 LPHLITKVRLHQLSEDTLQDYLLNEEYLLKSTNCFDIIVDA--IKCVQGSSGLFPDARPSTTEKY 292

  Fly   288 FFTGQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMM-RSRVGVAVLNGKLYAFGGFNG-- 349
            .|      :......||:..|. .|:..|..||:..|..:: .....::....|::..||..|
Mouse   293 IF------IHKTEENGENQYTF-CYNIKTDSWKILPQSHLIDLPGSSLSSYGEKIFLTGGCKGKC 350

  Fly   350 --TERLSTVEVYD----------PRKNKWSQGCAMLCKRSA-VGVAALDDCIYVCG---GYDGVT 398
              ..||...:.|.          |.||::....||...|:. ..|.||:....:.|   |...:.
Mouse   351 CRRIRLHIAQSYHDATDQTWCYCPAKNEFFCVSAMKTPRTMHTSVMALNRLFVIGGKTRGSQDIK 415

  Fly   399 SLNTVEVYYPKSNTWKTVAQMMK---YRSAGGVTQLNGYVYALGGHDGLSIFDSVE-------RY 453
            ||..||.|.|.|..|.:|:.:.:   |..|.....:   :|.||..  :.|.|:..       :|
Mouse   416 SLLDVESYNPLSREWTSVSPLPRGIYYPEASACQNI---IYVLGSE--VEIADAFNPSLDCFFKY 475

  Fly   454 DQAEDVWVKMSPMLNRRCRLGVATL------NGKIYVCGGYCGNSFLRSVECYD--PQTDTWKLV 510
            :...|.|   |.::....:...|||      |..:|:|.       |.:.:.|.  |.|..||..
Mouse   476 NATTDQW---SELVAEFGQFFHATLIKAVPVNCTLYICD-------LSTYKVYSFCPDTCVWKGE 530

  Fly   511 TPMNCKRSRVALAANMGKLWAIGG-YDGESNLSTVEVYDPETDKWTFMPPM 560
            ....|............|::.:|| |..:.....|:||.....:|..:.||
Mouse   531 GSFECAGFNAGAIGIEDKIYILGGDYAPDEITDEVQVYHSSRSEWEEVSPM 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	34/108 (31%)
		PHA03098	36..510	CDD:222983	132/510 (26%)
		KELCH repeat	329..372	CDD:276965	10/56 (18%)
		KELCH repeat	376..417	CDD:276965	14/44 (32%)
		KELCH repeat	423..466	CDD:276965	10/49 (20%)
		KELCH repeat	470..514	CDD:276965	12/51 (24%)
		Kelch_1	517..560	CDD:396078	8/43 (19%)
		KELCH repeat	517..560	CDD:276965	8/43 (19%)
Kbtbd3	NP_081238.2	BTB_POZ_KBTBD3_BKLHD3	24..153	CDD:349580	36/117 (31%)
		PHA03098	38..582	CDD:222983	144/570 (25%)
		Kelch 1. /evidence=ECO:0000255	291..337		9/52 (17%)
		KELCH repeat	330..385	CDD:276965	10/54 (19%)
		Kelch 2. /evidence=ECO:0000255	339..390		12/50 (24%)
		KELCH repeat	389..437	CDD:276965	15/47 (32%)
		Kelch 3. /evidence=ECO:0000255	400..450		13/49 (27%)
		KELCH repeat	440..485	CDD:276965	11/52 (21%)
		Kelch 4. /evidence=ECO:0000255	452..502		12/54 (22%)
		KELCH repeat	537..582	CDD:276965	10/45 (22%)
		Kelch 5. /evidence=ECO:0000255	548..595		10/34 (29%)