Protein Alignment KLHL18 and Klhl28

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_079983.1
• Gene: Klhl28 / 66689
• MGIID: 1913939
• Length: 571
• Species: Mus musculus
• Alignment Length: 532
• Identity: 203/532 - (38%)
• Similarity: 295/532 - (55%)
• Gaps: 15/532 - (2%)

  Fly    32 IRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSALESLI 96
            :|:..:|||:.|:|.|....||:||||:..|||.||||.|::|....|:..:  .|:.:||::::
Mouse    28 LRQHHELCDIILRVGDVKIHAHKVVLASISPYFKAMFTGNLSEKENSEVEFQ--CIDEAALQAIV 90

  Fly    97 NYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLIDA 161
            .|.|:|.|.|....|::|:..|:.||:..|...|.:||.|:..|.|.:||..||::..|..|..|
Mouse    91 EYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGNCIGISRFAETYGCHDLYLA 155

  Fly   162 ADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQV 226
            |.|:|.|||..|.|:|||..|....|.|::..|.|||.|||.:|.|...|:||...:|.:...|:
Mouse   156 ATKFICQNFESVCQTEEFFELTHADLDEIVSNDCLNVATEETVFYALESWIKYDVQERQKYLAQL 220

  Fly   227 LAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLLQS-FRTRQRSGEFFT 290
            |.:|||||||.:||........|||....|:.||:||..:|.|||.|...|: ..||.|..   .
Mouse   221 LNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNEALKYHFMPEHRLSHQTVLMTRPRCA---P 282

  Fly   291 GQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGGFNGTER--- 352
            ..:.||||.:.....:.:||:|.|....|.....:::.|...|:.||:.|::..||...:.|
Mouse   283 KVLCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVFVIGGIETSVRPGM 347

  Fly   353 -----LSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTSLNTVEVYYPKSNT 412
                 .::||.::|..|.|:....|...||.:|||.|...::..|||||.:.|.:||.|.||...
Mouse   348 TVRKHENSVECWNPDTNTWTSLERMNESRSTLGVAVLAGEVFALGGYDGQSYLQSVEKYIPKIRQ 412

  Fly   413 WKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVWVKMSPMLNRRCRLGVAT 477
            |:.||.|...||......|:|.:||:||: |.:..:||||||.::|.|..::||.::|...||..
Mouse   413 WQPVAPMTTTRSCFAAAVLDGMLYAIGGY-GPAHMNSVERYDPSKDSWEMVAPMADKRIHFGVGV 476

  Fly   478 LNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKRSRVALAANMGKLWAIGGYDGESNLS 542
            :.|.|:|.||:.|.|.|.|:|.|||..:.|.:..||...|:.|..|.....|:.:||:.|.|.|:
Mouse   477 MLGFIFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLN 541

  Fly   543 TVEVYDPETDKW 554
            ||:.|||.:|.|
Mouse   542 TVQKYDPISDTW 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	40/104 (38%)
		PHA03098	36..510	CDD:222983	184/482 (38%)
		KELCH repeat	329..372	CDD:276965	13/50 (26%)
		KELCH repeat	376..417	CDD:276965	18/40 (45%)
		KELCH repeat	423..466	CDD:276965	17/42 (40%)
		KELCH repeat	470..514	CDD:276965	18/43 (42%)
		Kelch_1	517..560	CDD:396078	16/38 (42%)
		KELCH repeat	517..560	CDD:276965	16/38 (42%)
Klhl28	NP_079983.1	PHA03098	35..553	CDD:222983	200/523 (38%)
		Kelch 1	284..331		13/46 (28%)
		KELCH repeat	321..372	CDD:276965	13/50 (26%)
		Kelch 2	332..386		16/53 (30%)
		KELCH repeat	376..419	CDD:276965	20/42 (48%)
		Kelch 3	387..433		18/45 (40%)
		KELCH repeat	423..465	CDD:276965	17/42 (40%)
		Kelch 4	435..479		18/44 (41%)
		KELCH repeat	469..513	CDD:276965	18/43 (42%)
		Kelch 5	480..526		18/45 (40%)
		KELCH repeat	516..559	CDD:276965	16/38 (42%)
		Kelch 6	528..570		13/26 (50%)