DRSC/TRiP Functional Genomics Resources

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Protein Alignment KLHL18 and KLHL25

DIOPT Version :9

Sequence 1:NP_001262494.1 Gene:KLHL18 / 41458 FlyBaseID:FBgn0037978 Length:575 Species:Drosophila melanogaster
Sequence 2:NP_071925.2 Gene:KLHL25 / 64410 HGNCID:25732 Length:589 Species:Homo sapiens


Alignment Length:561 Identity:168/561 - (29%)
Similarity:261/561 - (46%) Gaps:72/561 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 IRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSALESLI 96
            :|:.....||||...|:.|..||.||||:..||.|||::.:.|||...:..::: :.|..||.|:
Human    39 LRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDN-LHPEVLELLL 102

  Fly    97 NYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLIDA 161
            ::.||.::.|:.:|.::|:.....||..:||||.|.||.....|.|.||:...:|:..||:|.:.
Human   103 DFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLFPSNCLGMMLLSDAHQCRRLYEF 167

  Fly   162 ADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQV 226
            :.:....:|..|.|||:|.:|..:.||:|:..|||....|.|:|||.::|||:..:.|....|::
Human   168 SWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDELETEDERVVFEAILQWVKHDLEPRKVHLPEL 232

  Fly   227 LAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERR-----GLLQSFRTRQRSG 286
            |.:|||.||....|.:.|:.|.|:.:..:.:.::|||    |..:.|     |::.|...|.|..
Human   233 LRSVRLALLPSDCLQEAVSSEALLMADERTKLIMDEA----LRCKTRILQNDGVVTSPCARPRKA 293

  Fly   287 ----------EFFTGQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKL 341
                      .|...:||.|...|.  |.:...::..|              |.....:.:..|:
Human   294 GHTLLILGGQTFMCDKIYQVDHKAK--EIIPKADLPSP--------------RKEFSASAIGCKV 342

  Fly   342 YAFGGFNGTER--LSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGV------- 397
            |..|| .|:|.  ...|.|||....:||:...||..|...|.|.|::|:||.||:..:       
Human   343 YVTGG-RGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPAS 406

  Fly   398 --TSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGG----HDGLSIFDSVERYDQA 456
              .||..||.|.|.:|.|..||.:....|...|......::..||    .|.:|   .|:.||.:
Human   407 PSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVS---KVQCYDPS 468

  Fly   457 EDVWVKMSPMLNRRC-----RLGVATLNGKIYVCGG---YCGNSFLRSVECYDPQTDTWKLVTPM 513
            |:.|.     :...|     ....|.|..:|::.||   :...|..|    :|.:|:.|..:..|
Human   469 ENRWT-----IKAECPQPWRYTAAAVLGSQIFIMGGDTEFTAASAYR----FDCETNQWTRIGDM 524

  Fly   514 NCKRSRVALAANMGKLWAIGGYDGESNLSTVEVYDPETDKW 554
            ..||......|:..||:.:|||.|.....|::.|||.:|.|
Human   525 TAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTW 565

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KLHL18NP_001262494.1 BTB 29..135 CDD:279045 38/102 (37%)
PHA03098 36..510 CDD:222983 151/511 (30%)
BACK 143..245 CDD:285009 36/101 (36%)
Kelch 292..339 CDD:128874 7/46 (15%)
KELCH repeat 329..372 CDD:276965 13/44 (30%)
Kelch 340..386 CDD:128874 18/47 (38%)
KELCH repeat 376..417 CDD:276965 17/49 (35%)
Kelch 387..433 CDD:128874 17/54 (31%)
KELCH repeat 423..466 CDD:276965 11/46 (24%)
Kelch 435..480 CDD:128874 12/53 (23%)
Kelch_1 469..514 CDD:279660 11/52 (21%)
KELCH repeat 470..514 CDD:276965 11/51 (22%)
Kelch_1 517..560 CDD:279660 14/38 (37%)
KELCH repeat 517..560 CDD:276965 14/38 (37%)
KLHL25NP_071925.2 BTB_POZ_KLHL25 24..151 CDD:349563 41/112 (37%)
PHA03098 39..566 CDD:222983 168/561 (30%)
BACK_KLHL25_ENC2 144..242 CDD:350589 36/97 (37%)
Kelch 1 296..340 8/59 (14%)
KELCH repeat 330..374 CDD:276965 13/44 (30%)
Kelch 2 341..388 18/47 (38%)
KELCH repeat 378..431 CDD:276965 19/52 (37%)
Kelch 3 389..444 17/54 (31%)
KELCH repeat 434..480 CDD:276965 12/53 (23%)
Kelch 4 446..492 12/53 (23%)
KELCH repeat 482..524 CDD:276965 10/45 (22%)
Kelch 5 494..538 12/47 (26%)
Kelch 6 539..585 12/27 (44%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4441
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D312716at33208
OrthoFinder 1 1.000 - - FOG0000036
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X9
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.820

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