DRSC/TRiP Functional Genomics Resources

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Protein Alignment KLHL18 and KLHL12

DIOPT Version :9

Sequence 1:NP_001262494.1 Gene:KLHL18 / 41458 FlyBaseID:FBgn0037978 Length:575 Species:Drosophila melanogaster
Sequence 2:XP_011508137.1 Gene:KLHL12 / 59349 HGNCID:19360 Length:623 Species:Homo sapiens


Alignment Length:545 Identity:219/545 - (40%)
Similarity:312/545 - (57%) Gaps:7/545 - (1%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 IRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSALESLI 96
            :|:...||||||:||.:.|.|||:||||...||.||||:.::|.....:.::  .:..|.:|.|:
Human    81 LRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYVDIQ--GLTASTMEILL 143

  Fly    97 NYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLIDA 161
            ::||:..|.:..:|||.|:..|..|||..|:.||..||.|:..|.|.||||.||::..|..|:.|
Human   144 DFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNCLGIRDFAETHNCVDLMQA 208

  Fly   162 ADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQV 226
            |:.:..::|.:|.|.|||:.|...::.:|::.||:.|.:||.:|||.:.|||:|:.:|.|..|.:
Human   209 AEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEEPVFEAVINWVKHAKKEREESLPNL 273

  Fly   227 LAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLLQSFRTRQRSGEFFTG 291
            |..||:|||:|:::.|.:..|..||.|.|||||:||||.|||.||.|..:|..|||.|.|.  ..
Human   274 LQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDEAKKFHLRPELRSQMQGPRTRARLGA--NE 336

  Fly   292 QIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGGFNGTERLSTV 356
            .:..|||..|....:..||.|||.|::|.....::..|..|....|:.::|..||::|..|||:|
Human   337 VLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSV 401

  Fly   357 EVYDPRKNK---WSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTSLNTVEVYYPKSNTWKTVAQ 418
            |..|...::   |.....|..:|...|...|.|.|||.||:||.....::|.|.|..:.|..:..
Human   402 ECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGD 466

  Fly   419 MMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVWVKMSPMLNRRCRLGVATLNGKIY 483
            |...|...|:...:|.:|.|||:|||:|.:|||:||.....|..::||..:|...|||.||..||
Human   467 MQTAREGAGLVVASGVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIY 531

  Fly   484 VCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKRSRVALAANMGKLWAIGGYDGESNLSTVEVYD 548
            |.||:.|.:.|.|||.|:.:||:|..||.|...|..|......|:|:||.||||.|.||::|.||
Human   532 VVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYD 596

  Fly   549 PETDKWTFMPPMCAHSGGVGAGVIR 573
            |..|.|..:..|.......|..|:|
Human   597 PIIDSWEVVTSMGTQRCDAGVCVLR 621

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KLHL18NP_001262494.1 BTB 29..135 CDD:279045 42/102 (41%)
PHA03098 36..510 CDD:222983 192/476 (40%)
BACK 143..245 CDD:285009 41/101 (41%)
Kelch 292..339 CDD:128874 14/46 (30%)
KELCH repeat 329..372 CDD:276965 14/45 (31%)
Kelch 340..386 CDD:128874 15/48 (31%)
KELCH repeat 376..417 CDD:276965 15/40 (38%)
Kelch 387..433 CDD:128874 14/45 (31%)
KELCH repeat 423..466 CDD:276965 17/42 (40%)
Kelch 435..480 CDD:128874 21/44 (48%)
Kelch_1 469..514 CDD:279660 22/44 (50%)
KELCH repeat 470..514 CDD:276965 22/43 (51%)
Kelch_1 517..560 CDD:279660 19/42 (45%)
KELCH repeat 517..560 CDD:276965 19/42 (45%)
KLHL12XP_011508137.1 BTB 78..181 CDD:279045 41/101 (41%)
PHA03098 101..556 CDD:222983 182/458 (40%)
BACK 190..291 CDD:285009 41/100 (41%)
KELCH repeat 329..370 CDD:276965 14/42 (33%)
Kelch 337..384 CDD:128874 14/46 (30%)
KELCH repeat 374..420 CDD:276965 14/45 (31%)
Kelch 385..434 CDD:128874 15/48 (31%)
KELCH repeat 424..467 CDD:276965 15/42 (36%)
Kelch 436..481 CDD:128874 14/44 (32%)
KELCH repeat 471..514 CDD:276965 17/42 (40%)
Kelch 482..528 CDD:128874 21/45 (47%)
KELCH repeat 518..562 CDD:276965 22/43 (51%)
Kelch 529..575 CDD:128874 19/45 (42%)
KELCH repeat 565..610 CDD:276965 20/44 (45%)
Kelch 576..620 CDD:128874 18/43 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4441
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG59391
OrthoDB 1 1.010 - - D312716at33208
OrthoFinder 1 1.000 - - FOG0000036
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X9
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.830

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