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Protein Alignment KLHL18 and KLHL1

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_065917.1	Gene:	KLHL1 / 57626	HGNCID:	6352	Length:	748	Species:	Homo sapiens

Alignment Length:	578	Identity:	229/578 - (39%)
Similarity:	338/578 - (58%)	Gaps:	19/578 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DNSQVEDQYFVYKHDKLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFT 69
            |:|..|:.|....|.:   ::|...:...:..:||||.|.|.::...|||:||::...||.||||
Human   181 DSSSSEEFYQAVHHAE---QTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFT 242

  Fly    70 NNMAESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFL 134
            :::.|::.:||.|:  .|:|:||..|:.:.|:|.:.:....::||:..|..|||..|.:.|..||
Human   243 SDVCEAKQEEIKME--GIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFL 305

  Fly   135 ISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVR 199
            :...||.|.||||.|||:..|.:|:..|..|..:|..:|.:::|||.|..|:|.:|:..|::||.
Human   306 MKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVP 370

  Fly   200 TEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAK 264
            .||.||.|.|.||||....|......:||.:|||||.||.||| :....|.::..:|:.|:.||.
Human   371 DEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILAD-LENHALFKNDLECQKLILEAM 434

  Fly   265 DFHLMPERRGLLQSFRTRQRSGEFFTGQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMR 329
            .:||:||||.|:||.||:.|...  .|.:|||||: ...:..:|:|.||..|..|.....|:..|
Human   435 KYHLLPERRTLMQSPRTKPRKST--VGTLYAVGGM-DNNKGATTIEKYDLRTNLWIQAGMMNGRR 496

  Fly   330 SRVGVAVLNGKLYAFGGFNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGY 394
            .:.||||::.||:..||.:|.:.|:|||.|:|:...|:....|...|..:||..|:..||..||:
Human   497 LQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGH 561

  Fly   395 DGVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDV 459
            ||.:.|||||.:.|:|..|..||.|...||..||..|||.:|::||.||.|...|:|.||...:.
Human   562 DGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNK 626

  Fly   460 WVKMSPMLNRRCRLGVATLNGKIYVCGG-------YCGNSFLRSVECYDPQTDTWKLVTPMNCKR 517
            |...:||..||..:||||.:|.:|..||       :| :..|..||.|||:||||.:|.|::..|
Human   627 WNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHC-SRLLDYVERYDPKTDTWTMVAPLSMPR 690

  Fly   518 SRVALAANMGKLWAIGGYDGESNLSTVEVYDPETDKWTFMPPMCAHSGGVGAGVIRIE 575
            ..|.:.....:|:|:|||||::.|:|:|.|||:|::||.|..:  :.|..||.|:.|:
Human   691 DAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASL--NIGRAGACVVVIK 746

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.