Protein Alignment KLHL18 and KLHL14

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_065856.1
• Gene: KLHL14 / 57565
• HGNCID: 29266
• Length: 628
• Species: Homo sapiens
• Alignment Length: 582
• Identity: 149/582 - (25%)
• Similarity: 248/582 - (42%)
• Gaps: 79/582 - (13%)

  Fly    39 CDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNN------------------------MAESRIKE 79
            |||||..:.|.|..|:.|||:...||.::|:::                        ...|:.::
Human    33 CDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPLGGGVGGQDGLGAPKDQQQPPQQQPSQQQQ 97

  Fly    80 ITMKESAIEPSA-------------------------LESLINYVYSGQVRIDNQNVQNLMVGAS 119
            ...:|....||:                         |..::.|:|:..|.:....|:.::..:.
Human    98 PPPQEEPGTPSSSPDDKLLTSPRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSK 162

  Fly   120 FLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDC 184
            .|.:..|...|..||..:....|...:...|......:....|:||:         .|:.|.|:.
Human   163 ILHIPQVTKLCVQFLNDQISVQNYKQVCKIAALHGLEETKKLANKYL---------VEDVLLLNF 218

  Fly   185 EQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREEL 249
            |::..|:......|.:|..:|:..:.|:::..:.|.:..|.::..:|..|:....|.:||...:.
Human   219 EEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDF 283

  Fly   250 IRSSHQCRDLLDEAKDFHLMPERRGLLQSFRTRQRSGEFFTGQIYAVGGLASTGESV--STVEIY 312
            :|:...|:.||.:|.::||||.|:...||..:|.||.:   ..:..||||....:.:  :.|:.|
Human   284 MRTDPVCQKLLLDAMNYHLMPFRQHCRQSLASRIRSNK---KMLLLVGGLPPGPDRLPSNLVQYY 345

  Fly   313 DPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGGF-----NGTERLSTVEVYDPRKNKWSQGCAM 372
            |...|.||:...|....:...|..:...|:..||.     ||....:.|..||||.|.|.|...|
Human   346 DDEKKTWKILTIMPYNSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPM 410

  Fly   373 LCKRSAVGVAALDDCIYVCGGYDGVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYA 437
            ..:|::.....||..:||.||.:....|::||.|..::|.|:.|:.:.:..:|......||.:|.
Human   411 QERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYI 475

  Fly   438 LGG-HDGLSIFDSVERYDQAEDVWVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSF----LRSV 497
            .|| |:| .....:..||...|||.:...|..:|....:|.:|.::|..||.....|    :..|
Human   476 SGGVHNG-EYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLV 539

  Fly   498 ECYDPQTDTWKLV-TPMNCKRSRVALAANMGKLWAIGGYD---GESNLSTVEVYDPETDKWT 555
            |||||:.|.|.:: ||:...||....|.....::.:|||.   |....||: .|.||...||
Human   540 ECYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTI-CYCPEKGTWT 600

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	28/146 (19%)
		PHA03098	36..510	CDD:222983	133/531 (25%)
		KELCH repeat	329..372	CDD:276965	14/47 (30%)
		KELCH repeat	376..417	CDD:276965	13/40 (33%)
		KELCH repeat	423..466	CDD:276965	13/43 (30%)
		KELCH repeat	470..514	CDD:276965	17/48 (35%)
		Kelch_1	517..560	CDD:396078	14/42 (33%)
		KELCH repeat	517..560	CDD:276965	14/42 (33%)
KLHL14	NP_065856.1	BTB_POZ_KLHL14_printor	1..188	CDD:349552	29/154 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	69..115		4/45 (9%)
		BACK_KLHL14	181..282	CDD:350528	21/109 (19%)
		Kelch 1	323..372		12/48 (25%)
		NanM	324..577	CDD:442289	74/253 (29%)
		KELCH repeat	363..410	CDD:276965	14/46 (30%)
		Kelch 2	373..424		16/50 (32%)
		KELCH repeat	414..458	CDD:276965	14/43 (33%)
		Kelch 3	425..471		12/45 (27%)
		KELCH repeat	461..506	CDD:276965	14/45 (31%)
		Kelch 4	473..518		13/45 (29%)
		Kelch 5	520..570		17/49 (35%)
		Kelch_1	560..602	CDD:396078	14/42 (33%)
		KELCH repeat	560..602	CDD:276965	14/42 (33%)
		Kelch 6	572..620		11/30 (37%)