Protein Alignment KLHL18 and KLHL8

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_065854.3
• Gene: KLHL8 / 57563
• HGNCID: 18644
• Length: 620
• Species: Homo sapiens
• Alignment Length: 576
• Identity: 209/576 - (36%)
• Similarity: 325/576 - (56%)
• Gaps: 11/576 - (1%)

  Fly     3 LSDNSQVED----QYFVYKHDKLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPY 63
            :.:.|.:.|    ..|:::.::.:.:...........|:||||||||..:..|.|::|||..|||
Human    27 IKNRSSISDGDGEDSFIFEANEAWKDFHGSLLRFYENGELCDVTLKVGSKLISCHKLVLACVIPY 91

  Fly    64 FYAMFTNNMAESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRD 128
            |.|||.:.|||::...|.:::  .:..|:|.|:.:|||.::.:...|||.|:..|..||:..|..
Human    92 FRAMFLSEMAEAKQTLIEIRD--FDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVAR 154

  Fly   129 ACASFLISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRR 193
            ||..::...|||.|.|.:|.||:|.....|:|.||:|...:|.:|.:.|:|:::..:.|.:|:..
Human   155 ACCEYMKLHFHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSS 219

  Fly   194 DELNVRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRD 258
            .:||:..|:.::.|.:||:.......|:...:.||.||||||...||...||:|::::.:.:|||
Human   220 SDLNIENEKQVYNAAIKWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRD 284

  Fly   259 LLDEAKDFHLMPERRGLLQ---SFRTRQRSGEFFTGQIYAVGGLASTGESVSTVEIYDPLTKKWK 320
            |||||:::||....|.:..   |.||..|  :...|.::.|||...:|:...::|.|......|.
Human   285 LLDEARNYHLHLSSRAVPDFEYSIRTTPR--KHTAGVLFCVGGRGGSGDPFRSIECYSINKNSWF 347

  Fly   321 MGEQMSMMRSRVGVAVLNGKLYAFGGFNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALD 385
            .|.:|:..|..|||..:.||:||.||.:|.|.|.::|::||..|||....:|..||..:.:|:|.
Human   348 FGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLG 412

  Fly   386 DCIYVCGGYDGVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSV 450
            ..||..||.|..|..|.||.|..:|:.|.|||.|...|...|...|..:|||:||:||::...||
Human   413 GPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSV 477

  Fly   451 ERYDQAEDVWVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNC 515
            ||||...|.|:::..|..||...||:.|:|.:||.||:..||.|.|||.|||:::.|..|..:..
Human   478 ERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTT 542

  Fly   516 KRSRVALAANMGKLWAIGGYDGESNLSTVEVYDPETDKWTFMPPMCAHSGGVGAGV 571
            .|..|.:|..|||::|:||::|.:.|:|||.:||..::|..:..:.....|.|..|
Human   543 PRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAV 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	41/116 (35%)
		PHA03098	36..510	CDD:222983	185/476 (39%)
		KELCH repeat	329..372	CDD:276965	19/42 (45%)
		KELCH repeat	376..417	CDD:276965	16/40 (40%)
		KELCH repeat	423..466	CDD:276965	18/42 (43%)
		KELCH repeat	470..514	CDD:276965	20/43 (47%)
		Kelch_1	517..560	CDD:396078	17/42 (40%)
		KELCH repeat	517..560	CDD:276965	17/42 (40%)
KLHL8	NP_065854.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..35		1/7 (14%)
		BTB_POZ_KLHL8	52..171	CDD:349547	45/120 (38%)
		PHA03098	60..535	CDD:222983	184/478 (38%)
		Kelch 1	319..366		13/46 (28%)
		KELCH repeat	356..399	CDD:276965	19/42 (45%)
		Kelch 2	367..413		19/45 (42%)
		KELCH repeat	403..447	CDD:276965	18/43 (42%)
		Kelch 3	415..460		19/44 (43%)
		KELCH repeat	450..495	CDD:276965	19/44 (43%)
		Kelch 4	462..507		21/44 (48%)
		KELCH repeat	497..542	CDD:276965	20/44 (45%)
		Kelch 5	508..554		18/45 (40%)
		KELCH repeat	544..586	CDD:276965	17/41 (41%)
		Kelch	555..599	CDD:128874	15/44 (34%)
		Kelch 6	556..601		14/43 (33%)