DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KLHL18 and klhl8

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_001103950.1	Gene:	klhl8 / 572347	ZFINID:	ZDB-GENE-070209-226	Length:	604	Species:	Danio rerio

Alignment Length:	570	Identity:	200/570 - (35%)
Similarity:	327/570 - (57%)	Gaps:	8/570 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 NSQVE-DQYFVYKHDKLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFT 69
            ||:.: |..||::..:.:.:.....::....|:||||||||.::....|::|||..:|||.|||.
Zfish    17 NSEADADGSFVFEAQEAWKDFHNSLRQFYENGELCDVTLKVGNRLIPCHKLVLACVVPYFRAMFL 81

  Fly    70 NNMAESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFL 134
            ::|||::...|.:::  .:..|::.|:.:.||.::.:...|||.|:..|..||:..:..||..::
Zfish    82 SDMAEAKQDLIEIRD--FDADAIQDLVRFAYSSRLTLTVDNVQPLLYAACILQVELIARACCEYM 144

  Fly   135 ISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVR 199
            .:.|||.|.|.:||||:|.....|:|.||:|..::|::|.:.|:|:.:..:.|..|:...:||::
Zfish   145 KAHFHPSNCLAVRTFAESHNRVDLMDMADRYACEHFSQVVECEDFVCVSPQHLKTLLASSDLNIQ 209

  Fly   200 TEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAK 264
            .|..::.|.:||::..:...:....|::|.||||||..:||...||:||:|::|..||||||||:
Zfish   210 AETQVYNAAVKWLRANQKHHAVWLDQIMAQVRLPLLPVEFLTATVAKEEMIKASLSCRDLLDEAR 274

  Fly   265 DFHLMPERRGL---LQSFRTRQRSGEFFTGQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMS 326
            ::||....:.:   ..|.||..|  :...|.::.|||...:|:...::|.|......|..|.:|:
Zfish   275 NYHLHLSNKSVPDFQYSVRTTAR--KHTAGVLFCVGGRGGSGDPFRSIECYSISKNSWFFGPEMN 337

  Fly   327 MMRSRVGVAVLNGKLYAFGGFNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVC 391
            ..|..|||..:.||:||.||.:|.|.|.::|::||..|||....:|..||..:.:|||...:|..
Zfish   338 SRRRHVGVISVAGKVYAVGGHDGNEHLGSMEMFDPHTNKWMMRASMNTKRRGIALAALGGPLYAI 402

  Fly   392 GGYDGVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQA 456
            ||.|..:..:.||.|..:.:.|..||.|...|...|...|.|:|||:||:||::...||||:|..
Zfish   403 GGLDDNSCFSDVERYDIECDRWSAVAAMNTPRGGVGSVALGGFVYAVGGNDGVASLSSVERFDPH 467

  Fly   457 EDVWVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKRSRVA 521
            .:.|.::..|..||...||:.|:|.:||.||:..||.|.|||.:||:.:.|..|..:...|..|.
Zfish   468 LNKWTEVREMGQRRAGNGVSELHGCLYVVGGFDDNSPLSSVERFDPRLNRWDYVCELTTPRGGVG 532

  Fly   522 LAANMGKLWAIGGYDGESNLSTVEVYDPETDKWTFMPPMCAHSGGVGAGV 571
            :|..||:::|:||::|...|:|||.::|..::|..:..:.....|.|..|
Zfish   533 VATVMGRVFAVGGHNGNIYLNTVEAFEPRMNRWELVGSVSHCRAGAGVAV 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	36/105 (34%)
		PHA03098	36..510	CDD:222983	176/476 (37%)
		BACK	143..245	CDD:285009	33/101 (33%)
		Kelch	292..339	CDD:128874	13/46 (28%)
		KELCH repeat	329..372	CDD:276965	19/42 (45%)
		Kelch	340..386	CDD:128874	20/45 (44%)
		KELCH repeat	376..417	CDD:276965	12/40 (30%)
		Kelch	387..433	CDD:128874	14/45 (31%)
		KELCH repeat	423..466	CDD:276965	17/42 (40%)
		Kelch	435..480	CDD:128874	19/44 (43%)
		Kelch_1	469..514	CDD:279660	20/44 (45%)
		KELCH repeat	470..514	CDD:276965	19/43 (44%)
		Kelch_1	517..560	CDD:279660	15/42 (36%)
		KELCH repeat	517..560	CDD:276965	15/42 (36%)
klhl8	NP_001103950.1	BTB	41..145	CDD:279045	36/105 (34%)
		PHA03098	44..526	CDD:222983	177/485 (36%)
		BACK	153..255	CDD:285009	33/101 (33%)
		Kelch	303..350	CDD:128874	13/46 (28%)
		KELCH repeat	340..383	CDD:276965	19/42 (45%)
		Kelch	351..397	CDD:128874	20/45 (44%)
		KELCH repeat	387..431	CDD:276965	14/43 (33%)
		Kelch	399..444	CDD:128874	14/44 (32%)
		Kelch_1	433..478	CDD:279660	17/44 (39%)
		KELCH repeat	434..479	CDD:276965	18/44 (41%)
		KELCH repeat	481..525	CDD:276965	19/43 (44%)
		Kelch	492..538	CDD:128874	17/45 (38%)
		KELCH repeat	528..570	CDD:276965	15/41 (37%)
		Kelch	539..583	CDD:128874	13/44 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920