Protein Alignment KLHL18 and klhl35

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: XP_699490.4
• Gene: klhl35 / 570873
• ZFINID: ZDB-GENE-091118-66
• Length: 568
• Species: Danio rerio
• Alignment Length: 540
• Identity: 157/540 - (29%)
• Similarity: 266/540 - (49%)
• Gaps: 34/540 - (6%)

  Fly    33 RRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSALESLIN 97
            ||.|...||.|.|:...|..||..|.|:..:|..||.::..|||...:|:::  :..:|:|.|::
Zfish    35 RRSGTFTDVVLLVDGCEFPCHRATLCASSGFFRTMFGSHFTESRQAAVTLQD--VSRAAMEKLLD 97

  Fly    98 YVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLIDAA 162
            ::|.|::.:|.:|||::...|..|.:..:..||..||..|....|.||:.:||.:...:.|.:..
Zfish    98 FMYEGRLTLDEENVQSVFQAADRLDVPVLYKACVQFLQERVSHCNCLGLMSFAHAYGLQPLQEQC 162

  Fly   163 DKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQVL 227
            :..:.::..::.:..|||.|:.:|:|:::..:.|.|| |||:.||.::||.....|||....::|
Zfish   163 ETLLYRDLQQILRHPEFLQLEKQQVLDVLCCERLQVR-EEVLVEAALRWVHQQPAKRSAHLRELL 226

  Fly   228 AAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLLQSFRT--RQRSGEFFT 290
            ..:|||||...|....:..:|::|...:.||||.||:.:|.....   :||.||  |.|||  :.
Zfish   227 EPLRLPLLDQAFFCGTLEADEMVRDQPELRDLLQEARLYHAYGRE---VQSKRTTPRPRSG--WA 286

  Fly   291 GQIYAVGGLASTGES-VSTVEIYDPLTKKWKMGEQM-SMMRSRVGVAVLNGKLYAFGGFNGTERL 353
            ..|:..||...:|.| :|.:|..:..:.:|:....: ...:|......|...:|..||     :|
Zfish   287 EMIFVFGGCDKSGFSRLSFMEKLNVCSGQWQGAAAVPGYCKSEFAACELQNDIYLSGG-----QL 346

  Fly   354 STVEV--YDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTSLNTVEVYYPKSNTWKTV 416
            ::.:|  :.....:|.:.||:...|....:.:|...:||.|||:|...::|||.|.|..|:|.:|
Zfish   347 NSADVWRFMSSLGQWVRVCALSRGRWRHKMVSLCGKLYVVGGYNGRERVSTVERYSPHENSWISV 411

  Fly   417 AQMMKYRSAGGVTQLNGYVYALGGHDGLSIFD-----SVERYDQAEDVWVKMSPMLNRRCRLGVA 476
            :::....|:..:....|.:|.:||    :|.|     .|:.||...|.|..:||.......:...
Zfish   412 SELPLPVSSAALASCCGKLYVIGG----AISDHANTNQVQCYDPLTDSWSSVSPCPFSHRSISAV 472

  Fly   477 TLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKRSRVALAANMGKLWAIGGYDGESN- 540
            :|||.|||.||     .:..:.||.|..|.|.....:..:.....|....||::.:||...|:.
Zfish   473 SLNGSIYVAGG-----LMEHIYCYTPSKDCWSPAAKLPVRVEGCGLTVCAGKVYVVGGRTDEATA 532

  Fly   541 LSTVEVYDPETDKWTFMPPM 560
            ::....:||.:.|.|...||
Zfish   533 VNQSWSFDPLSGKVTEETPM 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	34/103 (33%)
		PHA03098	36..510	CDD:222983	143/484 (30%)
		KELCH repeat	329..372	CDD:276965	9/44 (20%)
		KELCH repeat	376..417	CDD:276965	15/40 (38%)
		KELCH repeat	423..466	CDD:276965	13/47 (28%)
		KELCH repeat	470..514	CDD:276965	13/43 (30%)
		Kelch_1	517..560	CDD:396078	10/43 (23%)
		KELCH repeat	517..560	CDD:276965	10/43 (23%)
klhl35	XP_699490.4	BTB_POZ_KLHL35	18..145	CDD:349574	36/111 (32%)
		BACK_KLHL35	138..215	CDD:350549	22/77 (29%)
		NanM	314..565	CDD:442289	66/253 (26%)
		KELCH repeat	328..367	CDD:276965	9/43 (21%)
		KELCH repeat	371..414	CDD:276965	16/42 (38%)
		KELCH repeat	418..463	CDD:276965	14/48 (29%)
		KELCH repeat	466..506	CDD:276965	13/44 (30%)
		KELCH repeat	510..552	CDD:276965	10/41 (24%)