DRSC/TRiP Functional Genomics Resources

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Protein Alignment KLHL18 and klhl35

DIOPT Version :9

Sequence 1:NP_001262494.1 Gene:KLHL18 / 41458 FlyBaseID:FBgn0037978 Length:575 Species:Drosophila melanogaster
Sequence 2:XP_699490.4 Gene:klhl35 / 570873 ZFINID:ZDB-GENE-091118-66 Length:568 Species:Danio rerio


Alignment Length:540 Identity:157/540 - (29%)
Similarity:266/540 - (49%) Gaps:34/540 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 RRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSALESLIN 97
            ||.|...||.|.|:...|..||..|.|:..:|..||.::..|||...:|:::  :..:|:|.|::
Zfish    35 RRSGTFTDVVLLVDGCEFPCHRATLCASSGFFRTMFGSHFTESRQAAVTLQD--VSRAAMEKLLD 97

  Fly    98 YVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLIDAA 162
            ::|.|::.:|.:|||::...|..|.:..:..||..||..|....|.||:.:||.:...:.|.:..
Zfish    98 FMYEGRLTLDEENVQSVFQAADRLDVPVLYKACVQFLQERVSHCNCLGLMSFAHAYGLQPLQEQC 162

  Fly   163 DKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQVL 227
            :..:.::..::.:..|||.|:.:|:|:::..:.|.|| |||:.||.::||.....|||....::|
Zfish   163 ETLLYRDLQQILRHPEFLQLEKQQVLDVLCCERLQVR-EEVLVEAALRWVHQQPAKRSAHLRELL 226

  Fly   228 AAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLLQSFRT--RQRSGEFFT 290
            ..:|||||...|....:..:|::|...:.||||.||:.:|.....   :||.||  |.|||  :.
Zfish   227 EPLRLPLLDQAFFCGTLEADEMVRDQPELRDLLQEARLYHAYGRE---VQSKRTTPRPRSG--WA 286

  Fly   291 GQIYAVGGLASTGES-VSTVEIYDPLTKKWKMGEQM-SMMRSRVGVAVLNGKLYAFGGFNGTERL 353
            ..|:..||...:|.| :|.:|..:..:.:|:....: ...:|......|...:|..||     :|
Zfish   287 EMIFVFGGCDKSGFSRLSFMEKLNVCSGQWQGAAAVPGYCKSEFAACELQNDIYLSGG-----QL 346

  Fly   354 STVEV--YDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTSLNTVEVYYPKSNTWKTV 416
            ::.:|  :.....:|.:.||:...|....:.:|...:||.|||:|...::|||.|.|..|:|.:|
Zfish   347 NSADVWRFMSSLGQWVRVCALSRGRWRHKMVSLCGKLYVVGGYNGRERVSTVERYSPHENSWISV 411

  Fly   417 AQMMKYRSAGGVTQLNGYVYALGGHDGLSIFD-----SVERYDQAEDVWVKMSPMLNRRCRLGVA 476
            :::....|:..:....|.:|.:||    :|.|     .|:.||...|.|..:||.......:...
Zfish   412 SELPLPVSSAALASCCGKLYVIGG----AISDHANTNQVQCYDPLTDSWSSVSPCPFSHRSISAV 472

  Fly   477 TLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKRSRVALAANMGKLWAIGGYDGESN- 540
            :|||.|||.||     .:..:.||.|..|.|.....:..:.....|....||::.:||...|:. 
Zfish   473 SLNGSIYVAGG-----LMEHIYCYTPSKDCWSPAAKLPVRVEGCGLTVCAGKVYVVGGRTDEATA 532

  Fly   541 LSTVEVYDPETDKWTFMPPM 560
            ::....:||.:.|.|...||
Zfish   533 VNQSWSFDPLSGKVTEETPM 552

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KLHL18NP_001262494.1 BTB 29..135 CDD:279045 33/101 (33%)
PHA03098 36..510 CDD:222983 143/484 (30%)
BACK 143..245 CDD:285009 31/101 (31%)
Kelch 292..339 CDD:128874 10/48 (21%)
KELCH repeat 329..372 CDD:276965 9/44 (20%)
Kelch 340..386 CDD:128874 10/47 (21%)
KELCH repeat 376..417 CDD:276965 15/40 (38%)
Kelch 387..433 CDD:128874 15/45 (33%)
KELCH repeat 423..466 CDD:276965 13/47 (28%)
Kelch 435..480 CDD:128874 13/49 (27%)
Kelch_1 469..514 CDD:279660 13/44 (30%)
KELCH repeat 470..514 CDD:276965 13/43 (30%)
Kelch_1 517..560 CDD:279660 10/43 (23%)
KELCH repeat 517..560 CDD:276965 10/43 (23%)
klhl35XP_699490.4 BTB 31..135 CDD:279045 33/101 (33%)
BTB 42..137 CDD:197585 31/96 (32%)
BACK 143..>221 CDD:197943 24/78 (31%)
KELCH repeat 328..367 CDD:276965 9/43 (21%)
KELCH repeat 371..414 CDD:276965 16/42 (38%)
Kelch 382..426 CDD:128874 15/43 (35%)
Kelch_1 417..463 CDD:279660 14/49 (29%)
KELCH repeat 418..463 CDD:276965 14/48 (29%)
KELCH repeat 466..506 CDD:276965 13/44 (30%)
Kelch 478..518 CDD:128874 11/44 (25%)
KELCH repeat 510..552 CDD:276965 10/41 (24%)
Kelch 519..564 CDD:128874 10/34 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000036
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.910

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