Protein Alignment KLHL18 and klhl43

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: XP_699069.5
• Gene: klhl43 / 570492
• ZFINID: ZDB-GENE-141212-285
• Length: 665
• Species: Danio rerio
• Alignment Length: 549
• Identity: 145/549 - (26%)
• Similarity: 250/549 - (45%)
• Gaps: 31/549 - (5%)

  Fly    28 LFKEIRRMGK---LCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEP 89
            |.:|:.||.:   |.|:.|..:.:.|..|::|:::...|...:...:....|::..|     :.|
Zfish    78 LLEELSRMRQERFLTDMELACKTKAFDVHKLVISSVSQYLREVLAKDPGLKRLELPT-----LSP 137

  Fly    90 SALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMI 154
            ..|.::|.:.|.|:|.:....:...:..||.||:.::...|..||::..:.|..:.:.....:..
Zfish   138 LGLANVITFAYLGRVHMSLYTIGCTVSAASTLQIPHLLQMCMDFLMAELNTHTCVYVWNIGAAYG 202

  Fly   155 CRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKR 219
            ...:.|||.:||.:|||:.|::.:|..|..||:...::.|.|.:.:|...|:..|||:.: :.||
Zfish   203 LMPVRDAARRYILENFAQFSETTQFNQLTFEQITAFLQDDNLILPSEVSTFQIAMKWLDF-DPKR 266

  Fly   220 SELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLLQSFRTRQR 284
            .|...::|:.||...:....|...:.....:....||..||.:|.::||:|.::..|||.||:.|
Zfish   267 QEHAAELLSHVRFETIPASELVSEIQPVPRMMLDPQCHRLLVDAMNYHLLPYQQNTLQSRRTKVR 331

  Fly   285 SGEFFTGQIYAVGGLASTGESVSTVEIY--DPL--TKKWKMGEQMSMMRSRVGVAVLNGKLYAFG 345
            ..:   ..:..:||..|..|...:.|:.  ||.  |..|:...|:........|||::|.||..|
Zfish   332 GSQ---NALLTIGGRPSLTERALSREVLWRDPREGTATWRHLTQLPAKSFNQCVAVMDGFLYVAG 393

  Fly   346 GFNGTE-------RLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTSLNTV 403
            |.:..:       .:.|:..||||.|.|....:|..:|:...:.|.:..:|..||.:....|.|:
Zfish   394 GEDQNDARNQAKHAVGTLSRYDPRFNTWLHLTSMRQRRTHFSLVATNGRLYAIGGRNTDGLLATI 458

  Fly   404 EVYYPKSNTWKTVAQMMKYRSAGGVTQL-NGYVYALGGHDGLSIFDSVERYDQAEDVWVKMSPML 467
            |.|.|.:|||:....|...|.......| :|.:...||:...:...||.:|....|.|.:...:.
Zfish   459 ESYQPSTNTWQLRTPMDMPRCCHSSAVLPSGDILVTGGYVNCAYSRSVIQYSIDRDAWSEKGELE 523

  Fly   468 NRRCRLGVATLNGKIYVCGG-YCGNSFLR----SVECYDPQTDTWKLVTPMNCKRSRVALAANMG 527
            ..|.....|.|.||:||.|| ..|...:|    ::|.|..::..|.....:....|...::....
Zfish   524 TPRGWHCSALLAGKVYVVGGSQLGAGGVRIDVMTMEVYSSESQEWSRAANLPIGVSTAGMSPIGS 588

  Fly   528 KLWAIGGY-DGESNL-STVEVYDPETDKW 554
            .|:.:||: :.|... |.|:.|||.||.|
Zfish   589 HLYILGGWNEAEKRYKSAVQRYDPGTDSW 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	26/111 (23%)
		PHA03098	36..510	CDD:222983	128/493 (26%)
		KELCH repeat	329..372	CDD:276965	15/49 (31%)
		KELCH repeat	376..417	CDD:276965	13/40 (33%)
		KELCH repeat	423..466	CDD:276965	10/43 (23%)
		KELCH repeat	470..514	CDD:276965	14/48 (29%)
		Kelch_1	517..560	CDD:396078	13/40 (33%)
		KELCH repeat	517..560	CDD:276965	13/40 (33%)
klhl43	XP_699069.5	BTB_POZ	74..193	CDD:453885	27/119 (23%)
		BACK	186..282	CDD:475122	27/96 (28%)
		NanM	365..626	CDD:442289	69/253 (27%)
		KELCH repeat	378..427	CDD:276965	15/48 (31%)
		KELCH repeat	431..475	CDD:276965	13/43 (30%)
		KELCH repeat	478..522	CDD:276965	10/43 (23%)
		KELCH repeat	526..575	CDD:276965	14/48 (29%)
		KELCH repeat	578..624	CDD:276965	13/40 (33%)