DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KLHL18 and kbtbd2

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_001070628.1	Gene:	kbtbd2 / 563254	ZFINID:	ZDB-GENE-060929-1262	Length:	631	Species:	Danio rerio

Alignment Length:	610	Identity:	151/610 - (24%)
Similarity:	252/610 - (41%)	Gaps:	121/610 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSALESLINYVYSG 102
            |.|:||.||:..|..|::|||....||.|||.:.::||:...:.::.  ::|..|:::|.|.|:|
Zfish    31 LTDITLLVEENEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRN--VDPITLQTIITYAYTG 93

  Fly   103 QVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLIDAADKYID 167
            .:.|::..|:.|...|.|||:.:|...|..:|:.:....|.:.:.:..|...|.:|..:|.:.::
Zfish    94 NLVINDSTVEPLYETACFLQVEDVLLQCREYLVKKITAENCVRMLSIGDMFSCTELKQSAKRMVE 158

  Fly   168 QNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRL 232
            ..|..|.:.|.||.|..|.||:|:..|.|||..||.:.||.|.|::|..:.||:....||:.:|:
Zfish   159 HKFPVVYRQEAFLQLSHELLLDLLSSDNLNVEKEETVREAAMLWLEYNMEGRSQYLSSVLSQIRI 223

  Fly   233 PLLS---------------------------PQFLADR--VAREELI--------RSSHQ----- 255
            ..||                           |:|...|  :.:||::        ..||.
Zfish   224 DALSEVTQRAWFQGLPPNDKSVVVQGLYKSMPKFFKPRLGMTKEEMLIFVEAEPPTESHPVVIGP 288

  Fly   256 -----CRDLLDEAKDFHLMPERRGLLQSFRTRQRSGEFFT--GQIYAVGG-------LASTGE-- 304
                 |..  .:|:..:.:....|.|      |:.|...|  ..::..||       ||:.|.
Zfish   289 RHTVVCYS--PQAEKVYKLCSLPGDL------QKVGTLVTPDNDVFIAGGQIPLKSTLATHGSKS 345

  Fly   305 --------SVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGGFN--GTERLSTVEVY 359
                    ||.:...:|.....|.....|...|::..:....|.:||.||.|  |.....|||.|
Zfish   346 GKLQAAYCSVDSFYWFDAQQNAWVAKTPMLHARTKPSLVFCQGFIYAIGGDNVGGELNKRTVERY 410

  Fly   360 DPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTSLNTVEVYYPKSNTWKTVAQMMKYRS 424
            |..:::||....:.|..|........||||       :.:.:.:..|:|:::||..:|.....|.
Zfish   411 DCERDEWSLTSPLPCAWSWSTAVTARDCIY-------IMTHDLMYCYFPRADTWVEMAMRQTSRC 468

  Fly   425 AGGVTQLNGYVYALGG-H--------------DGLSIFDSVERYDQAEDVWVKMSPMLNRR---- 470
            ......|...::.:|| |              ||.||  :||.||..::.|...:.:..:|
Zfish   469 FASAAALGDLIFYIGGLHVVGNSGLRLPTSTIDGSSI--TVEIYDVNKNEWRLAANIPAKRYSDP 531

  Fly   471 CRLGVATLNGK-IYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKRSRVALAANMGKLWAIGG 534
            |...|...|.. |::...:.......::..||.:.|.|.|..|::   .||        ||.:|
Zfish   532 CVRAVVLQNTLCIFIRETHLNERAKYALYQYDLELDCWSLRQPVS---ERV--------LWDLG- 584

  Fly   535 YDGESNLSTVEVYDPETDKWTFMPP 559
              .:...:..::|....|:..:.||
Zfish   585 --KDFRCAIGKLYPSCLDESPWKPP 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	33/96 (34%)
		PHA03098	36..510	CDD:222983	140/559 (25%)
		BACK	143..245	CDD:285009	35/130 (27%)
		Kelch	292..339	CDD:128874	11/63 (17%)
		KELCH repeat	329..372	CDD:276965	15/44 (34%)
		Kelch	340..386	CDD:128874	15/47 (32%)
		KELCH repeat	376..417	CDD:276965	9/40 (23%)
		Kelch	387..433	CDD:128874	10/45 (22%)
		KELCH repeat	423..466	CDD:276965	14/57 (25%)
		Kelch	435..480	CDD:128874	15/63 (24%)
		Kelch_1	469..514	CDD:279660	11/49 (22%)
		KELCH repeat	470..514	CDD:276965	11/48 (23%)
		Kelch_1	517..560	CDD:279660	9/43 (21%)
		KELCH repeat	517..560	CDD:276965	9/43 (21%)
kbtbd2	NP_001070628.1	PHA03098	24..524	CDD:222983	131/511 (26%)
		BTB	25..126	CDD:279045	33/96 (34%)
		BACK	134..228	CDD:285009	31/93 (33%)
		KELCH repeat	317..374	CDD:276965	10/56 (18%)
		Kelch_1	377..424	CDD:279660	15/46 (33%)
		KELCH repeat	378..424	CDD:276965	15/45 (33%)
		KELCH repeat	427..461	CDD:276965	9/40 (23%)
		KELCH repeat	467..524	CDD:276965	14/58 (24%)
		Kelch_1	467..522	CDD:279660	14/56 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810