Protein Alignment KLHL18 and klhl10b.1

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: XP_021322964.2
• Gene: klhl10b.1 / 560378
• ZFINID: ZDB-GENE-131015-2
• Length: 581
• Species: Danio rerio
• Alignment Length: 538
• Identity: 177/538 - (32%)
• Similarity: 273/538 - (50%)
• Gaps: 22/538 - (4%)

  Fly    28 LFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSAL 92
            :|.|.|.:|:..|:.::.....|..|::::.|..|||..:|::....:  .|.|.....:.|..|
Zfish    12 VFDEARLLGEHTDLIIRANGTKFQVHKIIMCACSPYFRVLFSSKWTST--AEHTYDIPEMSPDIL 74

  Fly    93 ESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFA-DSMICR 156
            ..:|.|.|:....|..:||..|:|.|..|.:|.:..||..||.:...|.|.:||.... |...|.
Zfish    75 YLIIQYAYTRSALITAENVLKLLVTADQLLISGLVAACCQFLDTHLGPENCIGIHMITKDFHSCS 139

  Fly   157 QLIDAADKYIDQNFAKVSQ-SEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRS 220
            :|...|.::|.|:|..|.| |||||.|..|:|.|::..|:||||.|||:|||.:.|:.:..:.|.
Zfish   140 KLHHKAKRFILQHFENVLQVSEEFLELPLEELEEIIDDDKLNVRHEEVVFEAILHWIDHEPESRR 204

  Fly   221 ELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAK----DFHL-MPERRGLLQSFR 280
            :....:|..|||.|::.|:..|.|....|:..:..|:.::..|.    ||.. .|....||...
Zfish   205 KHIATLLPKVRLGLMTLQYFMDNVKHNPLVMENEACKPIILSAMKALFDFQFDGPISSELLHRL- 268

  Fly   281 TRQRSGEFFTGQIYAVGGLASTGESVSTVEIYDPLTKKW----KMGEQMSMMRSRVGVAVLNGKL 341
            ||.|   ..:..:.|:||. |.|.: :.:|.:|...::|    |:.|:.:   :.:|.|||...:
Zfish   269 TRPR---LPSAILLAIGGW-SNGPT-NEIEAFDMRAEQWVNVNKVDERST---AYLGTAVLEEFV 325

  Fly   342 YAFGGFNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTSLNTVEVY 406
            |..||::..|..:.|..::.....|.:...|..:|..|.||.||..||..||:||:..||:.|.|
Zfish   326 YCIGGYDSVEYFNNVRKFNLITQTWHEVAPMYERRCYVSVAVLDGLIYAIGGFDGLERLNSAECY 390

  Fly   407 YPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVWVKMSPMLNRRC 471
            .|.:|.|...|||.:.||....:.|.|.||..||..|.....|.|.::...:.|..::||.:||.
Zfish   391 NPDTNQWTLTAQMNERRSDASASSLQGKVYICGGFTGTECLFSAECFNPQTNQWTLIAPMRSRRS 455

  Fly   472 RLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKRSRVALAANMGKLWAIGGYD 536
            .|||...:|.:|..||:.|.|.||:.|.|:|.|:.|:.|..|:..||...:.....:|:|:||:|
Zfish   456 GLGVIAYDGLVYAVGGFDGASRLRTAEAYNPLTNMWRDVASMHKTRSNFGIEVVDDQLFAVGGFD 520

  Fly   537 GESNLSTVEVYDPETDKW 554
            |...:|.|:.||.|.|:|
Zfish   521 GSGTISDVDCYDVEMDEW 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	31/108 (29%)
		PHA03098	36..510	CDD:222983	157/484 (32%)
		KELCH repeat	329..372	CDD:276965	10/42 (24%)
		KELCH repeat	376..417	CDD:276965	19/40 (48%)
		KELCH repeat	423..466	CDD:276965	12/42 (29%)
		KELCH repeat	470..514	CDD:276965	18/43 (42%)
		Kelch_1	517..560	CDD:396078	15/38 (39%)
		KELCH repeat	517..560	CDD:276965	15/38 (39%)
klhl10b.1	XP_021322964.2	PHA03098	25..554	CDD:222983	172/525 (33%)
		KELCH repeat	314..356	CDD:276965	10/41 (24%)
		KELCH repeat	360..403	CDD:276965	20/42 (48%)
		KELCH repeat	407..451	CDD:276965	13/43 (30%)
		KELCH repeat	454..498	CDD:276965	18/43 (42%)
		KELCH repeat	501..541	CDD:276965	15/38 (39%)