DRSC/TRiP Functional Genomics Resources

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Protein Alignment KLHL18 and KLHL7

DIOPT Version :9

Sequence 1:NP_001262494.1 Gene:KLHL18 / 41458 FlyBaseID:FBgn0037978 Length:575 Species:Drosophila melanogaster
Sequence 2:XP_006715816.1 Gene:KLHL7 / 55975 HGNCID:15646 Length:599 Species:Homo sapiens


Alignment Length:574 Identity:167/574 - (29%)
Similarity:282/574 - (49%) Gaps:31/574 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MDLSDNSQVEDQYFVYKHDKLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFY 65
            ::.|...:.|.:....:..||......:...:|:...||||.|.|:::...||||||||...:|.
Human     6 VEKSSKKKTEKKLAAREEAKLLAGFMGVMNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFN 70

  Fly    66 AMFTNNMAESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDAC 130
            .|||.||.||:..|:.:|::  ||..:|.|:.:.|:.::.:::.|||:|:..|:..|:..|:..|
Human    71 LMFTTNMLESKSFEVELKDA--EPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMC 133

  Fly   131 ASFLISRFHPHNVL-------------GIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLAL 182
            ..||..:....|.|             ||...|:.:.|.:|...||.:|.|:|.:|.:::|||.|
Human   134 VDFLKEQVDASNCLGEAEKVDQSLPECGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQL 198

  Fly   183 DCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVARE 247
            |.:::..|:.:|.|.||.|:.:::|.::|:||.|..|......:||.||.||:|..||:..|..|
Human   199 DVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAE 263

  Fly   248 ELIRSSHQCRDLLDEAKDFHLM-PE-RRGLLQSFRTRQRSGEFFTGQIYAVGGLASTGESVSTVE 310
            .||:.:.:|..::.....:||: || |..|:...|.|::..::   :|...|     |....:..
Human   264 PLIQDNPECLKMVISGMRYHLLSPEDREELVDGTRPRRKKHDY---RIALFG-----GSQPQSCR 320

  Fly   311 IYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGGFNGTERLSTVEVYDPRKNKWSQGCAMLCK 375
            .::|....|.........|........:..:|..|| :....:..::.|:..|:.|.........
Human   321 YFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGG-SQLFPIKRMDCYNVVKDSWYSKLGPPTP 384

  Fly   376 RSAVGVAALDDCIYVCGGYD-GVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALG 439
            |.::...|.:..||..||.: |.::|...|.|..::.:|.|...|:..|.:.|:.:.||.:|..|
Human   385 RDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCG 449

  Fly   440 GHDGLS----IFDSVERYDQAEDVWVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECY 500
            |..|.:    :.:|.|.||.|.:.|.::.||:..|...|:..:..||:..||..|...|.:||.|
Human   450 GSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYY 514

  Fly   501 DPQTDTWKLVTPMNCKRSRVALAANMGKLWAIGGYDGESNLSTVEVYDPETDKW 554
            |.:.:.||:|:||..|...|..||....::.:.|:.|...|..:..|:.|||||
Human   515 DIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 568

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KLHL18NP_001262494.1 BTB 29..135 CDD:279045 39/105 (37%)
PHA03098 36..510 CDD:222983 146/493 (30%)
BACK 143..245 CDD:285009 38/114 (33%)
Kelch 292..339 CDD:128874 6/46 (13%)
KELCH repeat 329..372 CDD:276965 7/42 (17%)
Kelch 340..386 CDD:128874 8/45 (18%)
KELCH repeat 376..417 CDD:276965 12/41 (29%)
Kelch 387..433 CDD:128874 13/46 (28%)
KELCH repeat 423..466 CDD:276965 14/46 (30%)
Kelch 435..480 CDD:128874 14/48 (29%)
Kelch_1 469..514 CDD:279660 16/44 (36%)
KELCH repeat 470..514 CDD:276965 16/43 (37%)
Kelch_1 517..560 CDD:279660 12/38 (32%)
KELCH repeat 517..560 CDD:276965 12/38 (32%)
KLHL7XP_006715816.1 BTB_POZ_KLHL7 23..148 CDD:349546 43/126 (34%)
PHA03098 37..568 CDD:222983 161/541 (30%)
BACK 140..250 CDD:391941 34/109 (31%)
KELCH repeat 385..429 CDD:276965 12/43 (28%)
KELCH repeat 433..481 CDD:276965 15/47 (32%)
KELCH repeat 484..528 CDD:276965 16/43 (37%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4441
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D312716at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X9
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

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