DRSC/TRiP Functional Genomics Resources

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Protein Alignment KLHL18 and KLHL7

DIOPT Version :10

Sequence 1:NP_650143.1 Gene:KLHL18 / 41458 FlyBaseID:FBgn0037978 Length:575 Species:Drosophila melanogaster
Sequence 2:NP_001026880.2 Gene:KLHL7 / 55975 HGNCID:15646 Length:586 Species:Homo sapiens


Alignment Length:561 Identity:167/561 - (29%)
Similarity:282/561 - (50%) Gaps:18/561 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MDLSDNSQVEDQYFVYKHDKLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFY 65
            ::.|...:.|.:....:..||......:...:|:...||||.|.|:::...||||||||...:|.
Human     6 VEKSSKKKTEKKLAAREEAKLLAGFMGVMNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFN 70

  Fly    66 AMFTNNMAESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDAC 130
            .|||.||.||:..|:.:|::  ||..:|.|:.:.|:.::.:::.|||:|:..|:..|:..|:..|
Human    71 LMFTTNMLESKSFEVELKDA--EPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMC 133

  Fly   131 ASFLISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDE 195
            ..||..:....|.|||...|:.:.|.:|...||.:|.|:|.:|.:::|||.||.:::..|:.:|.
Human   134 VDFLKEQVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDT 198

  Fly   196 LNVRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLL 260
            |.||.|:.:::|.::|:||.|..|......:||.||.||:|..||:..|..|.||:.:.:|..::
Human   199 LTVRAEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMV 263

  Fly   261 DEAKDFHLM-PE-RRGLLQSFRTRQRSGEFFTGQIYAVGGLASTGESVSTVEIYDPLTKKWKMGE 323
            .....:||: || |..|:...|.|::..::   :|...|     |....:...::|....|....
Human   264 ISGMRYHLLSPEDREELVDGTRPRRKKHDY---RIALFG-----GSQPQSCRYFNPKDYSWTDIR 320

  Fly   324 QMSMMRSRVGVAVLNGKLYAFGGFNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCI 388
            .....|........:..:|..|| :....:..::.|:..|:.|.........|.::...|.:..|
Human   321 CPFEKRRDAACVFWDNVVYILGG-SQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKI 384

  Fly   389 YVCGGYD-GVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLS----IFD 448
            |..||.: |.::|...|.|..::.:|.|...|:..|.:.|:.:.||.:|..||..|.:    :.:
Human   385 YTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLN 449

  Fly   449 SVERYDQAEDVWVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPM 513
            |.|.||.|.:.|.::.||:..|...|:..:..||:..||..|...|.:||.||.:.:.||:|:||
Human   450 SCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPM 514

  Fly   514 NCKRSRVALAANMGKLWAIGGYDGESNLSTVEVYDPETDKW 554
            ..|...|..||....::.:.|:.|...|..:..|:.|||||
Human   515 PWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 555

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KLHL18NP_650143.1 BTB_POZ_KLHL18 20..137 CDD:349556 42/116 (36%)
PHA03098 36..510 CDD:222983 146/480 (30%)
KELCH repeat 329..372 CDD:276965 7/42 (17%)
KELCH repeat 376..417 CDD:276965 12/41 (29%)
KELCH repeat 423..466 CDD:276965 14/46 (30%)
KELCH repeat 470..514 CDD:276965 16/43 (37%)
Kelch_1 517..560 CDD:396078 12/38 (32%)
KELCH repeat 517..560 CDD:276965 12/38 (32%)
KLHL7NP_001026880.2 BTB_POZ_KLHL7 23..148 CDD:349546 43/126 (34%)
PHA03098 37..555 CDD:222983 161/528 (30%)
BACK_KLHL7 140..237 CDD:350522 34/96 (35%)
Kelch 1 294..336 6/46 (13%)
Kelch 2 337..382 8/45 (18%)
KELCH repeat 372..416 CDD:276965 12/43 (28%)
Kelch 3 383..430 13/46 (28%)
KELCH repeat 420..468 CDD:276965 15/47 (32%)
Kelch 4 431..481 14/49 (29%)
KELCH repeat 471..515 CDD:276965 16/43 (37%)
Kelch 5 483..528 18/44 (41%)
Kelch 6 530..575 9/26 (35%)

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