Protein Alignment KLHL18 and klhl30

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: XP_688150.5
• Gene: klhl30 / 559694
• ZFINID: ZDB-GENE-100913-2
• Length: 593
• Species: Danio rerio
• Alignment Length: 529
• Identity: 146/529 - (27%)
• Similarity: 253/529 - (47%)
• Gaps: 60/529 - (11%)

  Fly    37 KLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSALESLINYVYS 101
            |..||||....:.|..||.:||....||::||:.:..||....:.:.:  ::|..|.||:::.|:
Zfish    31 KFVDVTLSAGGRDFPCHRGILALCSHYFHSMFSGDFIESIAARVELHD--VDPDVLSSLLDFAYT 93

  Fly   102 GQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLIDAADKYI 166
            |::.|:..||:.|:..:|.||...||..|..:|..:....|.|||..|.:...|.:::..|..::
Zfish    94 GKLTINKNNVEGLICTSSQLQFHTVRSVCCRYLQHQIDATNCLGILEFGEIHGCPEVVAKAWSFL 158

  Fly   167 DQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVR 231
            .:||..|.|.||||.|:.::|:..::.::|::|.:....||.:.||::::|.|.....::|:..:
Zfish   159 LENFEAVKQHEEFLQLEKDRLVACLKDEDLHLRDDRSCAEAVVSWVRHSKDSRICDLRELLSLAK 223

  Fly   232 LPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLLQSFRTRQRSGEFFTGQ---I 293
            |.|||..:|.:.:.:|.|:::|.:.|:|::     .:..|:|.|....:|.||:.:....|   :
Zfish   224 LSLLSESYLTENLLKEPLVQNSLESRELVE-----RICREKRQLTGDGKTEQRATQDAFNQQEVL 283

  Fly   294 YAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFG-GFNGTERLSTVE 357
            :.:|| .|..:|....|..|               .:|      :|:|:... ||...:.....:
Zfish   284 FVMGG-RSLDDSDDEDEDED---------------ENR------DGRLHPRNCGFYNPKLGQWFQ 326

  Fly   358 VYD-PRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTS--LNTVEV--YYPKSNTWKTVA 417
            :.| |..|||           ...|.:|::.:||.||..|..|  .:|.|.  |..:...|.|||
Zfish   327 LPDFPNYNKW-----------GYSVISLNNNVYVTGGSRGSQSNTWSTTETWKYITREGKWVTVA 380

  Fly   418 QMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVWVKMSPMLNRRCRLGVATLNGKI 482
            .|::.|:......|||.:|.:||    :..|.|||||...:.|...||.|............||:
Zfish   381 PMLRPRTNHSSATLNGEIYVIGG----TTTDFVERYDPFSNCWTLTSPALKYVTNFTATPCEGKL 441

  Fly   483 YVCGGYCGNSFLRSVECYDPQTDTWKLV-TPMNCKRSRVALAANM-GKLWAIGGYDGESNLSTVE 545
            |:.|.........:::||:|..|:|.:: :|...|......:.:| |.::.||     .|...|.
Zfish   442 YLIGSCAVKYNALTMQCYNPVIDSWCIIGSPFIPKYLSSPCSVSMDGVIYLIG-----DNTKKVY 501

  Fly   546 VYDPETDKW 554
            .|||:::.|
Zfish   502 SYDPDSNVW 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	33/99 (33%)
		PHA03098	36..510	CDD:222983	134/481 (28%)
		KELCH repeat	329..372	CDD:276965	10/44 (23%)
		KELCH repeat	376..417	CDD:276965	13/44 (30%)
		KELCH repeat	423..466	CDD:276965	15/42 (36%)
		KELCH repeat	470..514	CDD:276965	10/44 (23%)
		Kelch_1	517..560	CDD:396078	10/39 (26%)
		KELCH repeat	517..560	CDD:276965	10/39 (26%)
klhl30	XP_688150.5	None