Protein Alignment KLHL18 and KLHL9

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_061335.1
• Gene: KLHL9 / 55958
• HGNCID: 18732
• Length: 617
• Species: Homo sapiens
• Alignment Length: 572
• Identity: 177/572 - (30%)
• Similarity: 289/572 - (50%)
• Gaps: 43/572 - (7%)

  Fly    29 FKEIRRMGKLCDVTLKV--EDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSA 91
            |.::|..|.||||||..  .|:.|..||.::|:...||.||||..|.|..:  :.:|...:....
Human    40 FDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDL--MCIKLHGVNKVG 102

  Fly    92 LESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICR 156
            |:.:|:::|:.::.::..|:|:.:..|||||:..|.|.|..||||.....|.:.:...|::.
Human   103 LKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTY--- 164

  Fly   157 QLIDAADKYID----QNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAED 217
            .||: .|||::    :||..:..:.|||.|..|:|..::..:.|...||..:|:|..:|:: .||
Human   165 NLIE-VDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKAACRWLR-LED 227

  Fly   218 KRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLLQSFRTR 282
            .|.:...:::..:|.||::||.|.:.|...:.:|:.:.|.:||.||.::.:||..:.::||.||.
Human   228 PRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTA 292

  Fly   283 QRSGEFFTGQIYAVGGLASTGESVS-TVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGG 346
            .||.   :..:..:||:......|| .:.:||...::|:....|...|.:.|:||:...||..||
Human   293 IRSD---STHLVTLGGVLRQQLVVSKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGG 354

  Fly   347 -----FNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTSLNTVEVY 406
                 ..|...:.||..:|||.|||.|..::..||:...::||...:|..||......|.|||.|
Human   355 QSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECY 419

  Fly   407 YPKSNTWKTVAQMMK--YRSAGGVTQLNGYVYALGG--HDGLSIFDSVERYDQAEDVWVKMSPML 467
            .|:.|.|..||:|.:  |..||  |...|.:|..||  ||  :..:.:..:|...|.|::.:||.
Human   420 NPRMNEWSYVAKMSEPHYGHAG--TVYGGLMYISGGITHD--TFQNELMCFDPDTDKWMQKAPMT 480

  Fly   468 NRRCRLGVATLNGKIYVCGGYCGNSF--------LRSVECYDPQTDTWKLVTPMNCKRSRVALAA 524
            ..|....:.|:..|:||.|   ||.|        :.|.|.|.|..|.|..:..|...:|.|.:|.
Human   481 TVRGLHCMCTVGDKLYVIG---GNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAV 542

  Fly   525 NMGKLWAIGGYDGESN--LSTVEVYDPETDKWTFMPPMCAHSGGVGAGVIRI 574
            ...|::.:|||...:.  :..|:.||||.|:|..:..:....||:.|..:.:
Human   543 FENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTV 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	39/109 (36%)
		PHA03098	36..510	CDD:222983	157/497 (32%)
		KELCH repeat	329..372	CDD:276965	18/47 (38%)
		KELCH repeat	376..417	CDD:276965	14/40 (35%)
		KELCH repeat	423..466	CDD:276965	12/44 (27%)
		KELCH repeat	470..514	CDD:276965	15/51 (29%)
		Kelch_1	517..560	CDD:396078	14/44 (32%)
		KELCH repeat	517..560	CDD:276965	14/44 (32%)
KLHL9	NP_061335.1	BTB_POZ_KLHL9_13	27..154	CDD:349548	40/115 (35%)
		PHA03098	50..593	CDD:222983	173/559 (31%)
		Kelch 1	300..347		12/46 (26%)
		KELCH repeat	337..385	CDD:276965	18/47 (38%)
		Kelch 2	348..399		18/50 (36%)
		KELCH repeat	389..433	CDD:276965	16/43 (37%)
		Kelch 3	400..446		18/47 (38%)
		KELCH repeat	436..481	CDD:276965	15/48 (31%)
		Kelch 4	448..493		12/46 (26%)
		KELCH repeat	483..532	CDD:276965	15/51 (29%)
		Kelch 5	495..545		16/52 (31%)
		KELCH repeat	535..582	CDD:276965	14/46 (30%)
		Kelch 6	546..595		14/49 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	595..617		177/572 (31%)