DRSC/TRiP Functional Genomics Resources

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Protein Alignment KLHL18 and KBTBD4

DIOPT Version :10

Sequence 1:NP_650143.1 Gene:KLHL18 / 41458 FlyBaseID:FBgn0037978 Length:575 Species:Drosophila melanogaster
Sequence 2:NP_001305645.1 Gene:KBTBD4 / 55709 HGNCID:23761 Length:567 Species:Homo sapiens


Alignment Length:606 Identity:133/606 - (21%)
Similarity:230/606 - (37%) Gaps:145/606 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 SQVEDQYFVYKHDKLFGESFP---------------LFKEIRRMG-------KLC-------DVT 42
            |..|:..:.::.:||.....|               .||:....|       |||       |||
Human    33 SSSEESKYSWQREKLASMESPEEPGASMDENYFVNYTFKDRSHSGRVAQGIMKLCLEEELFADVT 97

  Fly    43 LKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSALESLINYVYSGQVRID 107
            :.||.:.|..||:||:|...:|.:|||:|:.|:..:.|.:::  :..|..:.|::|:|.|.|::.
Human    98 ISVEGREFQLHRLVLSAQSCFFRSMFTSNLKEAHNRVIVLQD--VSESVFQLLVDYIYHGTVKLR 160

  Fly   108 NQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAK 172
            .:.:|.:...:...||:::.:.|:.||.......|.|.:...||.....:|..||......:.|:
Human   161 AEELQEIYEVSDMYQLTSLFEECSRFLARTVQVGNCLQVMWLADRHSDPELYTAAKHCAKTHLAQ 225

  Fly   173 VSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSP 237
            :..:||||.|....|.:::..   .|...:...||...|:.:.:::| |.|.:.|          
Human   226 LQNTEEFLHLPHRLLTDIISD---GVPCSQNPTEAIEAWINFNKEER-EAFAESL---------- 276

  Fly   238 QFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLLQSFRTRQRSGEFFTGQIYAVGGLAST 302
                 |.:.:|:..:.|                                      ||.:|..:|.
Human   277 -----RTSLKEIGENVH--------------------------------------IYLIGKESSR 298

  Fly   303 GESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGGFNGTERL-----STVEVYDPR 362
            ..|:: |.::........:..|.|:...........|.||..|| :...|:     :||:     
Human   299 THSLA-VSLHCAEDDSISVSGQNSLCHQITAACKHGGDLYVVGG-SIPRRMWKCNNATVD----- 356

  Fly   363 KNKWSQGCAML----CKRSAVGVAALDDCIYVCGGYDGVTSLNTVEVYY-PKSNTWKTVAQMMKY 422
               | :.||.|    .:.:.|.|.. .|.||..||.....:|:...:|| ...|.|....|:...
Human   357 ---W-EWCAPLPRDRLQHTLVSVPG-KDAIYSLGGKTLQDTLSNAVIYYRVGDNVWTETTQLEVA 416

  Fly   423 RSAGGVTQLNGYVYALGGHDG-LSIFDSVERYDQAEDVWV---KMSP-MLNRRCRLGVATLNGKI 482
            .|......|||.:|.|||.:. |..|....|..|..|...   .:.| :|....|:..|.....:
Human   417 VSGAAGANLNGIIYLLGGEENDLDFFTKPSRLIQCFDTETDKCHVKPYVLPFAGRMHAAVHKDLV 481

  Fly   483 YVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKRSRVALA---ANMGKLWAIGGYDG------- 537
            ::...  |:|.:    ||:|..|::          :|:.|.   ::...||.|...:|       
Human   482 FIVAE--GDSLV----CYNPLLDSF----------TRLCLPEAWSSAPSLWKIASCNGSIYVFRD 530

  Fly   538 ---ESNLSTVEVYDPETDKWT 555
               :.:.:|.:: ||.|...|
Human   531 RYKKGDANTYKL-DPATSAVT 550

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KLHL18NP_650143.1 BTB_POZ_KLHL18 20..137 CDD:349556 39/145 (27%)
PHA03098 36..510 CDD:222983 115/502 (23%)
KELCH repeat 329..372 CDD:276965 10/47 (21%)
KELCH repeat 376..417 CDD:276965 12/41 (29%)
KELCH repeat 423..466 CDD:276965 14/47 (30%)
KELCH repeat 470..514 CDD:276965 8/43 (19%)
Kelch_1 517..560 CDD:396078 11/52 (21%)
KELCH repeat 517..560 CDD:276965 11/52 (21%)
KBTBD4NP_001305645.1 KELCH repeat 367..414 CDD:276965 13/47 (28%)
KELCH repeat 417..463 CDD:276965 13/45 (29%)
KELCH repeat 471..516 CDD:276965 10/60 (17%)
BTB_POZ_KBTBD4 62..201 CDD:349581 38/140 (27%)
PHA03098 96..528 CDD:222983 116/518 (22%)
BACK_KBTBD4 191..278 CDD:350556 22/105 (21%)
KELCH repeat 328..363 CDD:276965 11/44 (25%)

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