Protein Alignment KLHL18 and enc2

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: XP_009296127.1
• Gene: enc2 / 556885
• ZFINID: ZDB-GENE-131014-1
• Length: 625
• Species: Danio rerio
• Alignment Length: 604
• Identity: 178/604 - (29%)
• Similarity: 277/604 - (45%)
• Gaps: 83/604 - (13%)

  Fly     4 SDNSQVEDQYFVYKHD-------------KLFGE-SFP--LFKEIRRMGKLC---DVTLKVEDQT 49
            |:|..|.::..|..|:             .||.: |.|  :...:..:.|.|   ||||...|::
Zfish    28 SENLDVLEKMSVSVHENRKSRTSTGSMNISLFHKPSHPDSVLTHLNTLRKQCMFTDVTLWAGDRS 92

  Fly    50 FSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNL 114
            |..||.||||...||.|||:..:.||...|:..::| :.|..||.|:::.||.:|.|:.:|.::|
Zfish    93 FPCHRAVLAACSRYFEAMFSGGLRESLDNEVNFRDS-VHPEVLELLLDFAYSSRVIINEENAESL 156

  Fly   115 MVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEF 179
            :.....||..::|||.|.||....|..|.||:...:|:..|::|.:.:.:....:|..:..:|:|
Zfish   157 LEAGDMLQFHDIRDAAAEFLEKNLHASNCLGMMLLSDAHQCKRLYELSWRMCLIHFETLRDTEDF 221

  Fly   180 LALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRV 244
            ..|..::||:|:..|||.|..|:::|.|.|.||:|..|.|.:..|::|..:||.||..:.|.:.|
Zfish   222 CGLSKDKLLDLILSDELEVEDEQIVFNAVMHWVRYDLDSRRDYLPELLRGLRLALLPSECLIEAV 286

  Fly   245 AREELIRSSHQCRDLLDEAKDFHLMPERRGLLQS--------FRTRQR-------SGE-FFTGQI 293
            |.|||:.|..:.|.::|||     |..::.:||:        .|.|:.       .|: |...:|
Zfish   287 ACEELVMSDKRSRQIVDEA-----MQCKKKILQNDGVVTSPCARPRKAGHTLLILGGQTFMCDKI 346

  Fly   294 YAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGGFNGTER--LSTV 356
            |.|...|.  |.:...::..|              |.......:..|:|..|| .|:|.  ...|
Zfish   347 YQVDHKAK--EIIPKSDLPSP--------------RKEFSACAIGCKVYVTGG-RGSENGVSKDV 394

  Fly   357 EVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGV---------TSLNTVEVYYPKSNT 412
            .:||....:||:|..||..|...|.|.|::|:||.||:..:         .||..||.|.|.:|.
Zfish   395 WIYDTVHEEWSKGAPMLIARFGHGSAELENCLYVVGGHTAIAGVFPASPSVSLKQVERYDPLTNK 459

  Fly   413 WKTVAQMMKYRSAGGVTQLNGYVYALGG----HDGLSIFDSVERYDQAEDVWVKMSPMLNRRCRL 473
            |..:|.:....|...|......::..||    .|..|   .|:.||..|:.|...:.........
Zfish   460 WTMMAPLRDGVSNAAVVSAKLKLFVFGGTTIHRDKAS---KVQCYDPVENRWTIAAECPQPWRYT 521

  Fly   474 GVATLNGKIYVCGG---YCGNSFLRSVECYDPQTDTWKLVTPMNCKRSRVALAANMGKLWAIGGY 535
            ..|.|..:|::.||   :...|..|    :|.:|:.|..|..|..||......|:..||:.:|||
Zfish   522 AAAVLGSQIFIMGGDTEFTAASAYR----FDCETNLWTRVGDMTSKRMSCHAVASGNKLYVVGGY 582

  Fly   536 DGESNLSTVEVYDPETDKW 554
            .|.....|::.|||.:|.|
Zfish   583 FGTQRCKTLDCYDPTSDSW 601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	45/122 (37%)
		PHA03098	36..510	CDD:222983	152/510 (30%)
		KELCH repeat	329..372	CDD:276965	13/44 (30%)
		KELCH repeat	376..417	CDD:276965	17/49 (35%)
		KELCH repeat	423..466	CDD:276965	11/46 (24%)
		KELCH repeat	470..514	CDD:276965	11/46 (24%)
		Kelch_1	517..560	CDD:396078	14/38 (37%)
		KELCH repeat	517..560	CDD:276965	14/38 (37%)
enc2	XP_009296127.1	BTB_POZ	42..188	CDD:453885	49/146 (34%)
		BACK	180..267	CDD:475122	27/86 (31%)
		NanM	358..619	CDD:442289	72/266 (27%)
		KELCH repeat	366..410	CDD:276965	13/44 (30%)
		KELCH repeat	414..467	CDD:276965	18/52 (35%)
		KELCH repeat	470..516	CDD:276965	11/48 (23%)
		KELCH repeat	518..561	CDD:276965	11/46 (24%)
		KELCH repeat	564..609	CDD:276965	14/38 (37%)