Protein Alignment KLHL18 and si:ch211-256e16.3

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: XP_003198234.2
• Gene: si:ch211-256e16.3 / 556381
• ZFINID: ZDB-GENE-131127-256
• Length: 621
• Species: Danio rerio
• Alignment Length: 571
• Identity: 195/571 - (34%)
• Similarity: 302/571 - (52%)
• Gaps: 27/571 - (4%)

  Fly     9 VEDQYFVYKHDKLFGESFPLFKEIRRMGKL-------------CDVTLKVEDQTFSAHRVVLAAT 60
            |||..|..  ..|..|.: :|.|.|...|:             |||||....|.|..||:|||:.
Zfish    24 VEDSGFPL--SSLDSEDY-VFVETRHPNKVLEGLNSLRLNNAFCDVTLCCGGQEFPCHRIVLASF 85

  Fly    61 IPYFYAMFTNNMAESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSN 125
            ..||.|||:.::.|||.:.:.:  :.:||..:..|::|.|:.:|.|...|||.|:..|:.|.:..
Zfish    86 SSYFQAMFSTDLMESRQERVAI--NGVEPQMIGMLVSYAYTAEVVISKANVQALLAAANLLDVMA 148

  Fly   126 VRDACASFLISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLEL 190
            ||:||..|:..:....|.:||..||::..||:|...:.:||.|:|:.|||.||||:|..::|:|:
Zfish   149 VREACCRFMERQMDEMNCVGIHCFAEAHSCRELERRSMEYIQQHFSTVSQQEEFLSLCGDKLIEI 213

  Fly   191 MRRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQ 255
            :..|.|||..||.:|||.:.|::.:..:| :.|.:||..:||||:||.::.|.:...::::.|.|
Zfish   214 ISSDHLNVPKEETVFEAAIVWLEKSLSRR-QSFEKVLEHIRLPLISPYYIHDVIETLDVVKESLQ 277

  Fly   256 CRDLLDEAKDFHLMPERRGLLQSFRTRQRSGEFFTGQIYAVGGLASTGESVSTVEIYDPLTKKWK 320
            |:.|:.||||:.|:.:|||.|.|.|.|.|........|..||| ......:.:||.:|||..:||
Zfish   278 CQKLISEAKDYLLLQDRRGELYSPRARPRRATGTAEVIVTVGG-EDDKVVLRSVESFDPLNGQWK 341

  Fly   321 MGEQMSMMRSRVGVAVLNGKLYAFGG-FNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAAL 384
            ....:....|:.|:.|....||..|| |........:..|||..:.|.:...|...||.:|:..|
Zfish   342 SLACLPFAVSKHGLVVSGSMLYLAGGEFPDGSASREMWRYDPCFDSWLEMAPMNVARSELGLVML 406

  Fly   385 DDCIYVCGGYDGVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGG---HDGLSI 446
            |..::..||::|.:.|::||.|.|.:|||:.:..:....::..|..|:|.:|..||   .||...
Zfish   407 DGYVFAVGGWEGRSRLDSVECYNPHTNTWQFMESVKMAVTSPAVVSLDGLLYVTGGAVLEDGDGT 471

  Fly   447 FDSVERYDQAEDVWVKMSPMLNRRCRLGVATLNGKIYVCGG-YCGNSFLRSVECYDPQTDTWKLV 510
             |..:.|:....||.:::||...|.......|.|||||.|| :........||||||:|:.|.:.
Zfish   472 -DLAQVYNPKTCVWSEVAPMQIARSGSASCILKGKIYVIGGWHASTENTDKVECYDPKTNKWTMC 535

  Fly   511 TPMNCKRSRVALAANMGKLWAIGGYDG-ESNLSTVEVYDPETDKWTFMPPM 560
            .||..:|.|..:|...||::.:||.:| :....|:|.|..::|.|..:..|
Zfish   536 APMKERRYRPGVAVVDGKIYVLGGEEGWDRYHDTIERYCEDSDSWEIVGEM 586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	44/129 (34%)
		PHA03098	36..510	CDD:222983	170/491 (35%)
		KELCH repeat	329..372	CDD:276965	12/43 (28%)
		KELCH repeat	376..417	CDD:276965	16/40 (40%)
		KELCH repeat	423..466	CDD:276965	12/45 (27%)
		KELCH repeat	470..514	CDD:276965	18/44 (41%)
		Kelch_1	517..560	CDD:396078	13/43 (30%)
		KELCH repeat	517..560	CDD:276965	13/43 (30%)
si:ch211-256e16.3	XP_003198234.2	PHA03098	63..598	CDD:222983	185/529 (35%)
		KELCH repeat	306..346	CDD:276965	12/40 (30%)
		KELCH repeat	353..394	CDD:276965	11/40 (28%)
		KELCH repeat	398..490	CDD:276965	28/92 (30%)
		KELCH repeat	494..539	CDD:276965	18/44 (41%)
		KELCH repeat	542..588	CDD:276965	14/45 (31%)