Protein Alignment KLHL18 and klhl36

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: XP_073785212.1
• Gene: klhl36 / 553604
• ZFINID: ZDB-GENE-050522-324
• Length: 645
• Species: Danio rerio
• Alignment Length: 589
• Identity: 172/589 - (29%)
• Similarity: 286/589 - (48%)
• Gaps: 41/589 - (6%)

  Fly     3 LSDNSQV---EDQYFVYKHDKLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYF 64
            ||::|:|   .||    .::.|.|     ..|.|:.|::|||.|..:||...|||.:||.:.|||
Zfish    55 LSESSKVYRWADQ----ANNLLQG-----LNEQRQHGQMCDVVLVADDQRIPAHRALLAVSSPYF 110

  Fly    65 YAMFTNNMAESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDA 129
            .||||..|.|....||.:..::.  ..::::|:::|||.:.:|..|:..::..|..||:....|.
Zfish   111 QAMFTLGMREEHESEIELVGASY--VGVKAVIDFLYSGNLPLDGGNIDYVLETAHLLQVWQAVDF 173

  Fly   130 CASFLISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLA-LDCEQLLELMRR 193
            |..:|.......|.|.::..|......:|....|::|.::|:.::.:.|||. :...:|...:..
Zfish   174 CCQYLEKEVREDNYLYLQELALLYSLDRLDAFIDRFILKHFSTLAITSEFLQDVRMFKLCAYLSS 238

  Fly   194 DELNVRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVA---REELIRSSHQ 255
            :::....||.:||...||:| .:.:|.|...|:|:.:|..|: |.:|.....   ...|:.....
Zfish   239 EQVQCLNEETLFEVAFKWLK-QKPERLEFALQLLSNIRFALI-PFYLLKYYVLPNLHSLLPLDTS 301

  Fly   256 CRDLLDEAKDFHLMPERRGLLQSFRTRQRSGEFFTGQIYAVGG-LASTGESVSTVEIY-DPLTKK 318
            |:.|::||.|:|.....:.::|:.||..|.|   ...:..:|| ::..||.:|....: |....|
Zfish   302 CKVLVEEAIDYHRKLSAQPVMQTQRTGLRGG---VECLLLLGGEVSERGEGLSAEVCWLDEEAGK 363

  Fly   319 WKMGEQMSMMRSRVGVAVLNGKLYAFGGF----NGTERLSTVEV-YDPRKNKWSQGCAMLCKRSA 378
            |....:|...||:..||||.|.::..||.    ||.:..|.:.. ||||:..|.:|..|..:|..
Zfish   364 WVEETKMPAPRSQHCVAVLGGFIFTAGGSCSPDNGGDSASDMLYRYDPRRCHWIKGAPMNQRRVD 428

  Fly   379 VGVAALDDCIYVCGGYDGVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHD- 442
            ..:..:.:|:...||.:....|::||||:|..:.|..||::.|:......|...|.||..||||
Zfish   429 FYLGTMGECLIAVGGRNDSGPLSSVEVYHPADDHWTYVAELPKFTYGHAGTIHKGIVYISGGHDY 493

  Fly   443 --GLSIFDSVERYDQAEDVWVKMSPMLNRRCRLGVATLNGKIYVCGGYCG--NSFLR----SVEC 499
              |....|.:....:..|.|.:...|:..|....:|:|..:||..||...  :|..|    .||.
Zfish   494 QIGPYRHDMLSYDPKTADAWNECQAMILARGWHSMASLEDRIYAIGGSDDHEDSMERFDVLEVEA 558

  Fly   500 YDPQTDTWKLVTPMNCKRSRVALAANMGKLWAIGGYDGES-NLST-VEVYDPETDKWTFMPPMCA 562
            :||||:.|.::.|:....|...||....|::.:|||..|: :.|. .:|:||:.::||..|.:..
Zfish   559 FDPQTNQWTMIAPLRYASSEAGLAVLNRKIYVLGGYSWETMDFSQGTQVFDPDKEQWTLGPNLPK 623

  Fly   563 HSGG 566
            |..|
Zfish   624 HIAG 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	39/116 (34%)
		PHA03098	36..510	CDD:222983	144/493 (29%)
		KELCH repeat	329..372	CDD:276965	18/47 (38%)
		KELCH repeat	376..417	CDD:276965	11/40 (28%)
		KELCH repeat	423..466	CDD:276965	12/45 (27%)
		KELCH repeat	470..514	CDD:276965	17/49 (35%)
		Kelch_1	517..560	CDD:396078	15/44 (34%)
		KELCH repeat	517..560	CDD:276965	15/44 (34%)
klhl36	XP_073785212.1	None