DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KLHL18 and klhl40a

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_001122154.1	Gene:	klhl40a / 553257	ZFINID:	ZDB-GENE-050916-1	Length:	612	Species:	Danio rerio

Alignment Length:	555	Identity:	153/555 - (27%)
Similarity:	256/555 - (46%)	Gaps:	44/555 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 KLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSALESLINYVYS 101
            |..|..||::|:.|..||:|||||.|||.|||.:::.||:.:||.:|:  |||..:..::.|:|:
Zfish    32 KFVDCILKIKDKEFPCHRLVLAATSPYFKAMFLSDLEESKKREIVLKD--IEPGIMGMILRYIYT 94

  Fly   102 GQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLIDAADKYI 166
            ..:.:..||||::.:.|:..|:.::...|.|:|..:....|.|.|......:.|.:|...|..:|
Zfish    95 SDINLTEQNVQDIFMAANMYQIPSIFSVCVSYLQQKLVLSNCLAIFRLGLLLDCPRLAMEARDFI 159

  Fly   167 DQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVR 231
            ...:..:.:.::|..|...:|..::..|.|||..||.:||:.|.||:|..|:|::..|::|..||
Zfish   160 CDRYLLIIRDQDFHQLGPSELAAIITCDSLNVEREESVFESLMDWVEYDTDERTKELPELLHCVR 224

  Fly   232 LPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLL-----QSFRTRQRSGEFFTG 291
            ..|:...:..::|....|||::.:.:..|...||     .::|||     .|.|...:|.||.:.
Zfish   225 FRLMPTSYFKEKVEGHRLIRTNQELKKELQLIKD-----AQKGLLHRVKRSSHRKEGKSAEFESD 284

  Fly   292 QIYAVG---GLASTG------ESVSTVEIYDPLTKKWKMG--------EQMSMMRSRVGVAVLNG 339
            .....|   |:.:..      :|...:.|.|..|..:.:|        ....:.::...:.....
Zfish   285 DDDEDGLLPGILNDNPRFGMFQSDLILMINDAGTVAYDVGANECFVASSSTEIPKNHCSLVTKEN 349

  Fly   340 KLYAFGGFNGTER------LSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGG---YD 395
            :::..||....|.      .|....:||..::|....::...|...|:...::.|||.||   .:
Zfish   350 QIFVVGGLRYNEENKDQPFSSYFLQFDPMSSEWLGMPSLPNPRCLFGLVEAENSIYVVGGKELKE 414

  Fly   396 GVTSLNTVEVYYPKSNTWKTVAQMMKYRSAG-GVTQLNGYVYALGGH-DGLSIFDSVERYDQAED 458
            |..:|::|.:|..:|..|.. :..:.|...| |:....|.||.:||. :.......|..||.::.
Zfish   415 GERALDSVMIYDRQSFKWGE-SDPLPYAVYGHGIVSHKGLVYVIGGKTESKKCLRRVCVYDPSKF 478

  Fly   459 VWVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKRSRVALA 523
            .|..::||...|...|.|....||||..|...|....:||.||..:::|........:||.:.|.
Zfish   479 EWKDLAPMKTARSLFGTAVHKNKIYVVTGVTDNGLTSTVEVYDIASNSWSEFVDFPQERSSLNLV 543

  Fly   524 ANMGKLWAIGGYDGESNLSTVEVYDPE--TDKWTF 556
            ...|.|:||||:....| .|.|..:|.  .|.|.|
Zfish   544 ELGGFLYAIGGFAMMPN-ETTEKLEPTEMNDIWKF 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	37/97 (38%)
		PHA03098	36..510	CDD:222983	137/505 (27%)
		BACK	143..245	CDD:285009	28/101 (28%)
		Kelch	292..339	CDD:128874	7/63 (11%)
		KELCH repeat	329..372	CDD:276965	7/48 (15%)
		Kelch	340..386	CDD:128874	9/51 (18%)
		KELCH repeat	376..417	CDD:276965	13/43 (30%)
		Kelch	387..433	CDD:128874	14/49 (29%)
		KELCH repeat	423..466	CDD:276965	11/44 (25%)
		Kelch	435..480	CDD:128874	13/45 (29%)
		Kelch_1	469..514	CDD:279660	14/44 (32%)
		KELCH repeat	470..514	CDD:276965	14/43 (33%)
		Kelch_1	517..560	CDD:279660	16/42 (38%)
		KELCH repeat	517..560	CDD:276965	16/42 (38%)
klhl40a	NP_001122154.1	BTB	26..128	CDD:279045	37/97 (38%)
		PHA03098	48..540	CDD:222983	133/499 (27%)
		BACK	136..236	CDD:197943	28/99 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	266..290		5/23 (22%)
		KELCH repeat	341..388	CDD:276965	7/46 (15%)
		Kelch 1	350..402		9/51 (18%)
		Kelch	350..398	CDD:128874	9/47 (19%)
		Kelch_1	391..432	CDD:279660	12/40 (30%)
		KELCH repeat	392..438	CDD:276965	13/46 (28%)
		Kelch 2	403..452		14/49 (29%)
		KELCH repeat	442..487	CDD:276965	12/44 (27%)
		Kelch	453..500	CDD:128874	13/46 (28%)
		Kelch 3	453..500		13/46 (28%)
		Kelch_1	489..529	CDD:279660	14/39 (36%)
		KELCH repeat	490..535	CDD:276965	14/44 (32%)
		Kelch 4	502..547		13/44 (30%)
		Kelch 5	549..604		12/30 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810