Protein Alignment KLHL18 and klhl40a

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_001122154.1
• Gene: klhl40a / 553257
• ZFINID: ZDB-GENE-050916-1
• Length: 612
• Species: Danio rerio
• Alignment Length: 555
• Identity: 153/555 - (27%)
• Similarity: 256/555 - (46%)
• Gaps: 44/555 - (7%)

  Fly    37 KLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSALESLINYVYS 101
            |..|..||::|:.|..||:|||||.|||.|||.:::.||:.:||.:|:  |||..:..::.|:|:
Zfish    32 KFVDCILKIKDKEFPCHRLVLAATSPYFKAMFLSDLEESKKREIVLKD--IEPGIMGMILRYIYT 94

  Fly   102 GQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLIDAADKYI 166
            ..:.:..||||::.:.|:..|:.::...|.|:|..:....|.|.|......:.|.:|...|..:|
Zfish    95 SDINLTEQNVQDIFMAANMYQIPSIFSVCVSYLQQKLVLSNCLAIFRLGLLLDCPRLAMEARDFI 159

  Fly   167 DQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVR 231
            ...:..:.:.::|..|...:|..::..|.|||..||.:||:.|.||:|..|:|::..|::|..||
Zfish   160 CDRYLLIIRDQDFHQLGPSELAAIITCDSLNVEREESVFESLMDWVEYDTDERTKELPELLHCVR 224

  Fly   232 LPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLL-----QSFRTRQRSGEFFTG 291
            ..|:...:..::|....|||::.:.:..|...||     .::|||     .|.|...:|.||.:.
Zfish   225 FRLMPTSYFKEKVEGHRLIRTNQELKKELQLIKD-----AQKGLLHRVKRSSHRKEGKSAEFESD 284

  Fly   292 QIYAVG---GLASTG------ESVSTVEIYDPLTKKWKMG--------EQMSMMRSRVGVAVLNG 339
            .....|   |:.:..      :|...:.|.|..|..:.:|        ....:.::...:.....
Zfish   285 DDDEDGLLPGILNDNPRFGMFQSDLILMINDAGTVAYDVGANECFVASSSTEIPKNHCSLVTKEN 349

  Fly   340 KLYAFGGFNGTER------LSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGG---YD 395
            :::..||....|.      .|....:||..::|....::...|...|:...::.|||.||   .:
Zfish   350 QIFVVGGLRYNEENKDQPFSSYFLQFDPMSSEWLGMPSLPNPRCLFGLVEAENSIYVVGGKELKE 414

  Fly   396 GVTSLNTVEVYYPKSNTWKTVAQMMKYRSAG-GVTQLNGYVYALGGH-DGLSIFDSVERYDQAED 458
            |..:|::|.:|..:|..|.. :..:.|...| |:....|.||.:||. :.......|..||.::.
Zfish   415 GERALDSVMIYDRQSFKWGE-SDPLPYAVYGHGIVSHKGLVYVIGGKTESKKCLRRVCVYDPSKF 478

  Fly   459 VWVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKRSRVALA 523
            .|..::||...|...|.|....||||..|...|....:||.||..:::|........:||.:.|.
Zfish   479 EWKDLAPMKTARSLFGTAVHKNKIYVVTGVTDNGLTSTVEVYDIASNSWSEFVDFPQERSSLNLV 543

  Fly   524 ANMGKLWAIGGYDGESNLSTVEVYDPE--TDKWTF 556
            ...|.|:||||:....| .|.|..:|.  .|.|.|
Zfish   544 ELGGFLYAIGGFAMMPN-ETTEKLEPTEMNDIWKF 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	38/99 (38%)
		PHA03098	36..510	CDD:222983	137/505 (27%)
		KELCH repeat	329..372	CDD:276965	7/48 (15%)
		KELCH repeat	376..417	CDD:276965	13/43 (30%)
		KELCH repeat	423..466	CDD:276965	11/44 (25%)
		KELCH repeat	470..514	CDD:276965	14/43 (33%)
		Kelch_1	517..560	CDD:396078	16/42 (38%)
		KELCH repeat	517..560	CDD:276965	16/42 (38%)
klhl40a	NP_001122154.1	BTB_POZ_KLHL40_KBTBD5	7..140	CDD:349649	40/109 (37%)
		PHA03098	48..540	CDD:222983	133/499 (27%)
		BACK_KLHL40_KBTBD5	131..229	CDD:350591	29/97 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	266..290		5/23 (22%)
		KELCH repeat	341..388	CDD:276965	7/46 (15%)
		Kelch 1	350..402		9/51 (18%)
		KELCH repeat	392..438	CDD:276965	13/46 (28%)
		Kelch 2	403..452		14/49 (29%)
		KELCH repeat	442..487	CDD:276965	12/44 (27%)
		Kelch 3	453..500		13/46 (28%)
		KELCH repeat	490..535	CDD:276965	14/44 (32%)
		PRK14131	500..>585	CDD:237617	27/79 (34%)
		Kelch 4	502..547		13/44 (30%)
		Kelch 5	549..604		12/30 (40%)