DRSC/TRiP Functional Genomics Resources

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Protein Alignment KLHL18 and KLHL11

DIOPT Version :10

Sequence 1:NP_650143.1 Gene:KLHL18 / 41458 FlyBaseID:FBgn0037978 Length:575 Species:Drosophila melanogaster
Sequence 2:NP_060613.1 Gene:KLHL11 / 55175 HGNCID:19008 Length:708 Species:Homo sapiens


Alignment Length:576 Identity:143/576 - (24%)
Similarity:240/576 - (41%) Gaps:60/576 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 EIRRMGKLCDVTL---KVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMK----ESAIE 88
            |.||.|..||:||   ....:.|.|||.||||...||..:.:...:|||...:.|:    |...|
Human    86 EQRRQGLFCDITLCFGGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWSSEPGPE 150

  Fly    89 PSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSM 153
            |..:|::|.|:|:|::|:...:|..::..|....|..:::.|..||..:.|..|.:.|.:.|...
Human   151 PDTVEAVIEYMYTGRIRVSTGSVHEVLELADRFLLIRLKEFCGEFLKKKLHLSNCVAIHSLAHMY 215

  Fly   154 ICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDK 218
            ...||...|...|.:||.||.|.|||..|....:.:.:...|:.|.:|||:||..:|||:...::
Human   216 TLSQLALKAADMIRRNFHKVIQDEEFYTLPFHLIRDWLSDLEITVDSEEVLFETVLKWVQRNAEE 280

  Fly   219 RSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLLQSFRTRQ 283
            |...|.::...:||..:.|.:|...|..|.|:.::..|..|:.:|.:.|.:  |...:||...:.
Human   281 RERYFEELFKLLRLSQMKPTYLTRHVKPERLVANNEVCVKLVADAVERHAL--RAENIQSGTCQH 343

  Fly   284 RSGEFFT----GQ----IYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGK 340
            .:.....    ||    |..:||::..|:.:|....|.....:|.....:........|||....
Human   344 PTSHVSLLPRYGQNMDVIMVIGGVSEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESY 408

  Fly   341 LYAFG----GFNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVT-SL 400
            :|..|    ||     ..|||.|:|..|.|...|:::.::.:.|:..:...:|..||:...: ..
Human   409 VYVAGSMEPGF-----AKTVERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGF 468

  Fly   401 NTVEVYYPKSNTWKTVAQMMK-YRSAGGVTQLNGYVYALG-------GHDGLSIFDSVERYDQAE 457
            ..|.||.|:.:.|..:....| .|....:...:.:||...       ..|||...  :..||...
Human   469 KDVTVYNPELDKWHNLESAPKILRDVKALAIEDRFVYIAARTPVDRDTEDGLKAV--ITCYDTET 531

  Fly   458 DVW--VKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVT--------- 511
            ..|  |:..|:::..|...::.:|...|.....|..|:     |.:.:....|:.:         
Human   532 RQWQDVESLPLIDNYCFFQMSVVNSNFYQTASCCPKSY-----CLENEEAVRKIASQVSDEILES 591

  Fly   512 --PMNCKRSRVALAANMGKLWAIGGYDGESNL-----STVEVYDPETDKWTFMPPM 560
              |........|:......::.|||:....::     .....|..|..:|..:|||
Human   592 LPPEVLSIEGAAICYYKDDVFIIGGWKNSDDIDKQYRKEAYRYCAERKRWMLLPPM 647

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KLHL18NP_650143.1 BTB_POZ_KLHL18 20..137 CDD:349556 37/112 (33%)
PHA03098 36..510 CDD:222983 129/503 (26%)
KELCH repeat 329..372 CDD:276965 15/46 (33%)
KELCH repeat 376..417 CDD:276965 9/41 (22%)
KELCH repeat 423..466 CDD:276965 10/51 (20%)
KELCH repeat 470..514 CDD:276965 8/54 (15%)
Kelch_1 517..560 CDD:396078 8/47 (17%)
KELCH repeat 517..560 CDD:276965 8/47 (17%)
KLHL11NP_060613.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 47..70
BTB_POZ_KLHL11 71..205 CDD:349550 38/118 (32%)
PHA03098 90..553 CDD:222983 123/471 (26%)
BACK_KLHL11 200..287 CDD:350526 29/86 (34%)
Kelch 1 360..407 10/46 (22%)
KELCH repeat 399..439 CDD:276965 15/44 (34%)
Kelch 2 408..453 13/49 (27%)
KELCH repeat 443..488 CDD:276965 9/44 (20%)
Kelch 3 455..501 10/45 (22%)
KELCH repeat 491..541 CDD:276965 10/51 (20%)
Kelch 4 503..556 11/54 (20%)
KELCH repeat 567..649 CDD:276965 14/86 (16%)
Kelch 5 610..661 9/38 (24%)
Kelch 611..657 CDD:128874 9/37 (24%)
Blue background indicates that the domain is not in the aligned region.

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