Protein Alignment KLHL18 and klhl8

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_001017289.1
• Gene: klhl8 / 550043
• XenbaseID: XB-GENE-995628
• Length: 616
• Species: Xenopus tropicalis
• Alignment Length: 567
• Identity: 209/567 - (36%)
• Similarity: 321/567 - (56%)
• Gaps: 4/567 - (0%)

  Fly     7 SQVE-DQYFVYKHDKLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTN 70
            |:|: |..||::.|:.:.|..........:|:||||||||..:....|::|||..||||.|||.:
 Frog    30 SEVDGDGTFVFEADEAWKEFHRSLLHFYEVGELCDVTLKVGSKLIPCHKLVLACVIPYFRAMFLS 94

  Fly    71 NMAESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLI 135
            :|||:  |:..::....:..|:|.|:.:.||..|.:...|||.|:..|..||:..|..||..::.
 Frog    95 DMAET--KQTLIEIQDFDGDAIEDLVKFSYSSCVTLTVDNVQPLLYAACILQVELVAKACCEYMK 157

  Fly   136 SRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRT 200
            ..|||.|.|.:|.||:|.....|:|.||:|...:|.:|...::|:.:..:.|.:|:...:||:..
 Frog   158 LHFHPSNCLAVRAFAESHNRVDLMDMADRYACDHFTEVVDCDDFVTMTPQHLYKLLSSGDLNIEN 222

  Fly   201 EEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKD 265
            |:.::.|.|||:.......:....::|:.||||||..:||...||:|::|:.:.:||||||||::
 Frog   223 EKQVYNAAMKWLHANPQYHTAWLDEILSQVRLPLLPVEFLMSVVAKEDIIKQNLKCRDLLDEARN 287

  Fly   266 FHLMPERRGLLQ-SFRTRQRSGEFFTGQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMR 329
            :||....|.|.. .:..|....:...|.::.|||...:|:...::|.|......|..|.:|:..|
 Frog   288 YHLYLSNRSLPDFEYTARTIPRKQTAGVLFCVGGRGGSGDPFRSIECYSVTKNSWFFGPEMNSRR 352

  Fly   330 SRVGVAVLNGKLYAFGGFNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGY 394
            ..|||..:.||:||.||.:|.|.|.::|::||..|||....:|..||..:.:::|...||..||.
 Frog   353 RHVGVISVGGKVYAVGGHDGNEHLGSMELFDPLTNKWMMKASMNTKRRGIALSSLGGPIYAIGGL 417

  Fly   395 DGVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDV 459
            |..|..|.||.|..:|:.|.:||.|:..|...|...|..:|||:||:||::...||||||...|.
 Frog   418 DDNTCFNDVERYDIESDHWTSVAPMISPRGGVGSVALMSHVYAVGGNDGVASLSSVERYDPHLDK 482

  Fly   460 WVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKRSRVALAA 524
            ||::..|..||...||:.|:|.:||.||:..||.|.|||.|||:.:.|..|:.:...|..|.:|.
 Frog   483 WVEVKEMGQRRAGNGVSELHGCLYVVGGFDDNSPLSSVERYDPRMNKWDYVSELTTPRGGVGIAT 547

  Fly   525 NMGKLWAIGGYDGESNLSTVEVYDPETDKWTFMPPMCAHSGGVGAGV 571
            .|||::|:||::|.:.|:|||.|||..::|..:..:.....|.|..|
 Frog   548 LMGKIYAVGGHNGNAYLNTVESYDPRINRWELVGSVAHCRAGAGVAV 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	41/116 (35%)
		PHA03098	36..510	CDD:222983	180/474 (38%)
		KELCH repeat	329..372	CDD:276965	19/42 (45%)
		KELCH repeat	376..417	CDD:276965	14/40 (35%)
		KELCH repeat	423..466	CDD:276965	19/42 (45%)
		KELCH repeat	470..514	CDD:276965	20/43 (47%)
		Kelch_1	517..560	CDD:396078	18/42 (43%)
		KELCH repeat	517..560	CDD:276965	18/42 (43%)
klhl8	NP_001017289.1	BTB_POZ_KLHL8	48..167	CDD:349547	45/120 (38%)
		PHA03098	56..531	CDD:222983	179/476 (38%)
		KELCH repeat	352..395	CDD:276965	19/42 (45%)
		KELCH repeat	399..443	CDD:276965	16/43 (37%)
		KELCH repeat	446..491	CDD:276965	20/44 (45%)
		KELCH repeat	493..537	CDD:276965	20/43 (47%)
		KELCH repeat	540..582	CDD:276965	18/41 (44%)
		Kelch	551..595	CDD:128874	16/44 (36%)