DRSC/TRiP Functional Genomics Resources

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Protein Alignment KLHL18 and klhl32

DIOPT Version :10

Sequence 1:NP_650143.1 Gene:KLHL18 / 41458 FlyBaseID:FBgn0037978 Length:575 Species:Drosophila melanogaster
Sequence 2:XP_012818485.1 Gene:klhl32 / 549611 XenbaseID:XB-GENE-5858956 Length:657 Species:Xenopus tropicalis


Alignment Length:577 Identity:163/577 - (28%)
Similarity:277/577 - (48%) Gaps:52/577 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 RRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSALESLIN 97
            |..|.|||:||..|:|.|.||:.||||...||.|||:..|.||...|:.:  ..:....|:..::
 Frog    73 RNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMFSLCMVESEADEVNL--HGVTSLGLKQALD 135

  Fly    98 YVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLIDAA 162
            :.|:||:.::...:|:::...|.|||..:.:.|:.:||...:..|.|.:...||......|..|.
 Frog   136 FAYTGQILLEPGAIQDVLAAGSHLQLLELLNLCSQYLIQELNSFNYLDLYKLADLFNLTLLETAV 200

  Fly   163 DKYIDQNFAKV--SQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQ 225
            .:::.::.:::  :..||.|||....|.|:::.|:|...:||.|::..::|:::  :.|.:...:
 Frog   201 VEFLVKHLSELLKNHPEEVLALPFRLLREVLKSDQLTSMSEEQIWQLAVRWLEH--NCRYQYMDE 263

  Fly   226 VLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLLQSFRTRQRSGEFFT 290
            :|..||..|:....|........||:||.....|::||.::|.....:.:.|:.||..|   |.:
 Frog   264 LLQYVRFGLMDTNTLHTVALSHPLIQSSETATALINEALEYHQSIYAQPVWQTIRTEPR---FQS 325

  Fly   291 GQIYAVGGLASTGESVSTVEIYDPLTKK---------WKMGEQMSMMRSRVGVAVLNGKLYAFGG 346
            ..:|.|||.......|..:..::|:.::         |.....|.:.||...||::...|:|.||
 Frog   326 NTLYIVGGKKREICKVRELRYFNPIDQENVHIAGIANWSELTPMPVGRSHHCVAIMGNFLFAAGG 390

  Fly   347 --FNGTERLSTVEV---YDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTS-LNTVEV 405
              .:.:.|...|..   ||||.|.|.:...|...|....:.|:.|.:|..||.:.:.. |.:||.
 Frog   391 EVEHASGRTCAVRTACRYDPRSNSWIEIAPMKNCREHFVLGAVGDLLYAVGGRNELRQVLPSVER 455

  Fly   406 YYPKSNTWKTVAQMMKYRS----AGGVTQLNGYVYALGGHDGLSIFDS-VERYDQAEDVWVKMSP 465
            |.||.|.| |.||... ||    ||.|.  :|.::..||....:.:.: :..||.:::.|:..||
 Frog   456 YCPKKNKW-TFAQSFD-RSLSCHAGCVA--DGLLWISGGVTNTAQYQNRLMVYDPSQNKWISRSP 516

  Fly   466 MLNRRCRLGVATLNGKIYVCGG----YCGNSFL-RSVECYDPQTDTW-----KLVTPMNCKRSRV 520
            ||.||....:|.:..|:||.||    |..:..| |.::.|:..||.|     .|:|..|    ..
 Frog   517 MLQRRVYHAMAAVQRKLYVLGGNDLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQN----ES 577

  Fly   521 ALAANMGKLWAIGGYDGESN--LSTVEVYDPE---TDKWTFMPPMCAHSGGVGAGVI 572
            .:|...|:::.:|||...:|  |:.::|.|..   .::..:.|.:...|.|:.|..:
 Frog   578 GVAVYNGRIYLVGGYSIWTNEPLACIQVLDVSREGKEEVFYGPTLPFASNGIAASFL 634

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KLHL18NP_650143.1 BTB_POZ_KLHL18 20..137 CDD:349556 37/103 (36%)
PHA03098 36..510 CDD:222983 146/505 (29%)
KELCH repeat 329..372 CDD:276965 16/47 (34%)
KELCH repeat 376..417 CDD:276965 15/41 (37%)
KELCH repeat 423..466 CDD:276965 12/47 (26%)
KELCH repeat 470..514 CDD:276965 16/53 (30%)
Kelch_1 517..560 CDD:396078 10/47 (21%)
KELCH repeat 517..560 CDD:276965 10/47 (21%)
klhl32XP_012818485.1 BTB_POZ_KLHL32 51..183 CDD:349570 38/111 (34%)
PHA03098 74..564 CDD:222983 145/500 (29%)
BACK_KLHL32_BKLHD5 176..273 CDD:350546 23/98 (23%)
KELCH repeat 373..421 CDD:276965 16/47 (34%)
KELCH repeat 425..470 CDD:276965 17/45 (38%)
KELCH repeat 473..519 CDD:276965 12/47 (26%)
KELCH repeat 521..571 CDD:276965 14/49 (29%)

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