Protein Alignment KLHL18 and gan

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: XP_012816560.1
• Gene: gan / 549284
• XenbaseID: XB-GENE-1013088
• Length: 604
• Species: Xenopus tropicalis
• Alignment Length: 563
• Identity: 152/563 - (26%)
• Similarity: 250/563 - (44%)
• Gaps: 60/563 - (10%)

  Fly    30 KEIRRMGK------LCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIE 88
            |.:|.:|.      .||..|.:|.|.....|.:|||..||..|....|..::......::...|.
 Frog    21 KLLRALGSFRGESGFCDALLVLEGQEIPVQRNILAAASPYIRAKLNYNPPKNDGSIYRIELEGIS 85

  Fly    89 PSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSM 153
            ...::.:::|::|||:|:..:.:|:::..|..|.|::::..|..||.......|.:|||.||...
 Frog    86 VDVMKEILDYIFSGQIRLSEETIQDVVQAADLLLLTDLKTLCCEFLEGCITAENCIGIRDFALHY 150

  Fly   154 ICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDK 218
            ....:...|.::::.:|..||.:||||.|...:..|::..::|||..|:.:|||.::|:.:..:.
 Frog   151 CLNHVHYVATEFLETHFRDVSSTEEFLELSPTKAKEVLSLEKLNVGNEKYVFEAVLRWLSHDLEA 215

  Fly   219 RSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRG--LLQSFRT 281
            |......|.:|:.:..|...:|.:::..|.|:      |:::.|..:..|...:.|  :|.||:.
 Frog   216 RKVHMKDVSSALWVSGLDSSYLREKMLIEPLV------REMVRECSNIPLSQPQHGEAVLASFKP 274

  Fly   282 RQRSGEFFTGQIYAVGGLASTG-ESVSTVE----IYDPLTKKWKMGEQMSMMRSRVGVAVLNGKL 341
            |.     ::..|..|||...|. :.:::|.    :|||..:.|.....:|..|...||....|.|
 Frog   275 RG-----YSECIVTVGGEERTSRKPLASVRCMCPLYDPNRQLWIELAPLSTPRINHGVLSAEGFL 334

  Fly   342 YAFGGFN-GTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTSLNTVEV 405
            :..||.| ..|.|.|.|.|||..|.||....||..|.:.|:..:|..|||.||.:|.:.|.::|.
 Frog   335 FVLGGQNEDNETLDTGEQYDPDDNAWSPLPPMLEARHSFGMVEIDGVIYVLGGENGDSELLSMES 399

  Fly   406 YYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVWVKMSPMLNRR 470
            |...:.||.....|...|..|....:...:||:||.....:|:|||.||.....|..:.|:..||
 Frog   400 YDTCTKTWSKQQNMTMVRKIGCYAAMKKKIYAMGGGSYGKLFESVECYDPKTQQWTAICPLKERR 464

  Fly   471 -----CRLGVATLNGKIYVCGGY--------------CGNSFLRSVECYDPQTDTWKLVTPMN-C 515
                 |.:|:     ::||.||.              |.:.|      |......|..:...| |
 Frog   465 FGAVACGVGM-----ELYVFGGVRSRDNDNQNSDMVACKSEF------YHDDFKRWIYLNDQNLC 518

  Fly   516 ---KRSRVALAANMG-KLWAIGGYDGESNLSTVEVYDPETDKW 554
               ..|.|..|..:| .::.||..|..::...|..:...|..|
 Frog   519 IPTSSSFVYGAVPIGASIYVIGDLDTGTSYDYVREFKRSTGTW 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	29/112 (26%)
		PHA03098	36..510	CDD:222983	138/506 (27%)
		KELCH repeat	329..372	CDD:276965	18/43 (42%)
		KELCH repeat	376..417	CDD:276965	14/40 (35%)
		KELCH repeat	423..466	CDD:276965	13/42 (31%)
		KELCH repeat	470..514	CDD:276965	11/62 (18%)
		Kelch_1	517..560	CDD:396078	10/39 (26%)
		KELCH repeat	517..560	CDD:276965	10/39 (26%)
gan	XP_012816560.1	BTB_POZ_KLHL16_gigaxonin	22..132	CDD:349554	27/109 (25%)
		PHA03098	35..509	CDD:222983	136/495 (27%)
		BACK_KLHL16_gigaxonin	136..232	CDD:350530	27/95 (28%)
		KELCH repeat	322..366	CDD:276965	18/43 (42%)
		KELCH repeat	370..414	CDD:276965	14/43 (33%)
		KELCH repeat	417..462	CDD:276965	14/44 (32%)