DRSC/TRiP Functional Genomics Resources

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Protein Alignment KLHL18 and KLHL28

DIOPT Version :9

Sequence 1:NP_001262494.1 Gene:KLHL18 / 41458 FlyBaseID:FBgn0037978 Length:575 Species:Drosophila melanogaster
Sequence 2:NP_001295041.1 Gene:KLHL28 / 54813 HGNCID:19741 Length:585 Species:Homo sapiens


Alignment Length:532 Identity:205/532 - (38%)
Similarity:293/532 - (55%) Gaps:15/532 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 IRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSALESLI 96
            :|:..:|||:.|:|.|....||:||||:..|||.||||.|::|....|:..:  .|:.:||::::
Human    42 LRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEVEFQ--CIDETALQAIV 104

  Fly    97 NYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLIDA 161
            .|.|:|.|.|....|::|:..|:.||:..|...|.:||.|:..|.|.:||..||::..||.|..|
Human   105 EYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGNCIGISRFAETYGCRDLYLA 169

  Fly   162 ADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQV 226
            |.|||.|||..|.|:|||..|....|.|::..|.|||.|||.:|.|...|:||...:|.:...|:
Human   170 ATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEETVFYALESWIKYDVQERQKYLAQL 234

  Fly   227 LAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLLQS-FRTRQRSGEFFT 290
            |.:|||||||.:||........|||....|:.||:||..:|.|||.|...|: ..||.|..   .
Human   235 LNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNEALKYHFMPEHRLSHQTVLMTRPRCA---P 296

  Fly   291 GQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGGFNGTER--- 352
            ..:.||||.:.....:.:||:|.|....|.....:::.|...|:.||:.|:|..||.....|   
Human   297 KVLCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGV 361

  Fly   353 -----LSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTSLNTVEVYYPKSNT 412
                 .::||.::|..|.|:....|...||.:||..|...:|..|||||.:.|.:||.|.||...
Human   362 TIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRK 426

  Fly   413 WKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVWVKMSPMLNRRCRLGVAT 477
            |:.||.|...||......|:|.:||:||: |.:..:||||||.::|.|..::.|.::|...||..
Human   427 WQPVAPMTTTRSCFAAAVLDGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGV 490

  Fly   478 LNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKRSRVALAANMGKLWAIGGYDGESNLS 542
            :.|.|:|.||:.|.|.|.|:|.|||..:.|.:..||...|:.|..|.....|:.:||:.|.|.|:
Human   491 MLGFIFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLN 555

  Fly   543 TVEVYDPETDKW 554
            ||:.|||.:|.|
Human   556 TVQKYDPISDTW 567

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KLHL18NP_001262494.1 BTB 29..135 CDD:279045 39/102 (38%)
PHA03098 36..510 CDD:222983 186/482 (39%)
BACK 143..245 CDD:285009 47/101 (47%)
Kelch 292..339 CDD:128874 13/46 (28%)
KELCH repeat 329..372 CDD:276965 14/50 (28%)
Kelch 340..386 CDD:128874 16/53 (30%)
KELCH repeat 376..417 CDD:276965 18/40 (45%)
Kelch 387..433 CDD:128874 19/45 (42%)
KELCH repeat 423..466 CDD:276965 17/42 (40%)
Kelch 435..480 CDD:128874 17/44 (39%)
Kelch_1 469..514 CDD:279660 18/44 (41%)
KELCH repeat 470..514 CDD:276965 18/43 (42%)
Kelch_1 517..560 CDD:279660 16/38 (42%)
KELCH repeat 517..560 CDD:276965 16/38 (42%)
KLHL28NP_001295041.1 PHA03098 49..567 CDD:222983 202/523 (39%)
KELCH repeat 335..386 CDD:276965 14/50 (28%)
KELCH repeat 390..433 CDD:276965 20/42 (48%)
KELCH repeat 437..479 CDD:276965 17/42 (40%)
KELCH repeat 483..527 CDD:276965 18/43 (42%)
KELCH repeat 530..573 CDD:276965 16/38 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4441
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG59391
OrthoDB 1 1.010 - - D312716at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X9
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.830

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