DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KLHL18 and KLHL24

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_001336342.1	Gene:	KLHL24 / 54800	HGNCID:	25947	Length:	625	Species:	Homo sapiens

Alignment Length:	603	Identity:	197/603 - (32%)
Similarity:	303/603 - (50%)	Gaps:	54/603 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DLSDNSQVEDQYFVYKHDKLFGES-FPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFY 65
            ::...|....::|.:.......|: ..:|.|.|......||.:.||.:.|..||.||:|...||.
Human    28 EMDPKSLTGHEFFDFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFR 92

  Fly    66 AMFTNNMAESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDAC 130
            |||.|:..|||  |:.::.:.|...|:|..:.|||:|:|:|..:|||.|...:|..|:|.:||||
Human    93 AMFCNDHRESR--EMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDAC 155

  Fly   131 ASFLISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDE 195
            |.||..:..|.|.|||:.|||:...:.|......:..|.|..|||.||||.||.::|::.:..||
Human   156 AKFLEEQLDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDE 220

  Fly   196 LNVRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLL 260
            |.:..||::|||.|:||..|.|.|..|..::|..||||||.|.:....|..::||::|.:|..||
Human   221 LVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLL 285

  Fly   261 DEAKDFHLMPERRGLLQSFRTRQRSGEFFTGQIYAVGGLASTGE-SVSTVEIYDPLTKKWK-MGE 323
            .||:.:|::...   :.|.|||.|....::..|..|||....|. ::...|.|||:|.:|| :.:
Human   286 HEARRYHILGNE---MMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSLAK 347

  Fly   324 QMSMMRSRVGVAVLNGKLYAFGGFNGTERLST--VEVYDPR-----------KNKWSQGCAML-- 373
            .....:|...|..|...:...||     |:::  |.:|:.:           |.:|....|:|
Human   348 LPEFTKSEYAVCALRNDILVSGG-----RINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLG 407

  Fly   374 ---CKRSAVG--------VAALDDC-IYVCGGYDGVTSLNTVEVYYPKSNTWKTVAQMMKYRSAG 426
               .|.|.:|        :.||.:. :||.|||||...|::||.|...||.|..||.:.:..|:.
Human   408 KGFLKTSILGQSWWLTPVIPALWEAKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSP 472

  Fly   427 GVTQLNGYVYAL-GGHDGLSIFDSVERYDQAEDVWVKMSPM-LNRRCRLGVATLNGKIYVCGGYC 489
            .||...|.::.: ||.|..:..|.|:.||...:.|:..:.: :.:|| :...:||..|||.||
Human   473 AVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRC-ITAVSLNNLIYVAGG-- 534

  Fly   490 GNSFLRSVECYDPQTDTWKLVTPMNCKRSRVALAANMGKLWAIGG--YDGESNLSTVEVYDPETD 552
               ..:::.||||..|.|..|.....::....::...||::.:||  .:||:. .|:..|||.|.
Human   535 ---LTKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEAT-DTILCYDPATS 595

  Fly   553 KWT---FMPPMCAHSGGV 567
            ..|   .||...::.|.|
Human   596 IITGVAAMPRPVSYHGCV 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	45/105 (43%)
		PHA03098	36..510	CDD:222983	174/504 (35%)
		BACK	143..245	CDD:285009	42/101 (42%)
		Kelch	292..339	CDD:128874	15/48 (31%)
		KELCH repeat	329..372	CDD:276965	10/55 (18%)
		Kelch	340..386	CDD:128874	14/71 (20%)
		KELCH repeat	376..417	CDD:276965	18/49 (37%)
		Kelch	387..433	CDD:128874	19/46 (41%)
		KELCH repeat	423..466	CDD:276965	12/43 (28%)
		Kelch	435..480	CDD:128874	11/46 (24%)
		Kelch_1	469..514	CDD:279660	16/44 (36%)
		KELCH repeat	470..514	CDD:276965	16/43 (37%)
		Kelch_1	517..560	CDD:279660	14/47 (30%)
		KELCH repeat	517..560	CDD:276965	14/47 (30%)
KLHL24	NP_001336342.1	BTB	62..591	CDD:333434	182/545 (33%)
		KELCH repeat	354..393	CDD:276965	8/43 (19%)
		KELCH repeat	397..466	CDD:276965	24/68 (35%)
		KELCH repeat	469..514	CDD:276965	12/44 (27%)
		KELCH repeat	517..556	CDD:276965	16/44 (36%)
		KELCH repeat	559..604	CDD:276965	12/45 (27%)
		Kelch	570..616	CDD:128874	15/45 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810