Protein Alignment KLHL18 and Kbtbd12

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_001418799.1
• Gene: Kbtbd12 / 502859
• RGDID: 1585999
• Length: 627
• Species: Rattus norvegicus
• Alignment Length: 608
• Identity: 167/608 - (27%)
• Similarity: 276/608 - (45%)
• Gaps: 83/608 - (13%)

  Fly     1 MDLSDNSQVEDQYFVYKHDKLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFY 65
            |:.....:.:.|:.:...||:        |.::.:.::.||.|..|::.|..||:||||..|||.
  Rat     1 MESKTEGKGKHQHSLNLLDKI--------KTMKELEEMVDVVLIAEEEKFPCHRLVLAAFSPYFK 57

  Fly    66 AMFTNNMAESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDAC 130
            ||||..:.|...||:.:.:  |...::..::||:||..:.|:|.|||.:.:.|.|:|:..|...|
  Rat    58 AMFTCGLLECTQKEVILYD--ITAESVSVILNYMYSAVLEINNANVQTVAMAAYFMQMEEVFSVC 120

  Fly   131 ASFLISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDE 195
            .::::......|.:||..||..:....|.|.:.||:.|:||:||...|.|.::..|||.|::.|:
  Rat   121 QNYMMDHMDASNCIGIYYFAKQIGAEDLSDQSKKYLYQHFAEVSLHGEILDIEAHQLLALIKSDD 185

  Fly   196 LNVRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLL 260
            ||:..||.|.:..::||.:.:..|:|...::|..|||.|::..||...:.|..::.....|.|::
  Rat   186 LNISREESILDLVLRWVNHNQALRTEHLVELLKQVRLELINASFLRQALRRNTMLLCDGSCIDMI 250

  Fly   261 DEAKDFHLMPERRGLLQSFRTRQRSGEFFTGQIYAVG----GLASTGESVSTVEI-YDPLTKKW- 319
            ..|......|      |...:..|.|...|..:..:|    |:.|...|...... |||:::|.
  Rat   251 QNAFKAIKTP------QQHSSNLRYGMETTSLLLCIGNNSSGIRSRHRSYGDASFCYDPVSQKTY 309

  Fly   320 -----KMGEQMSMMRSRVGVAVLNGKLYAFGGFNGTERLS-----TVEV--YDPRKNK-WSQGCA 371
                 |.||.:..:.:  ||.:.|..:...|....| |||     .:|:  |..|.|: |.:
  Rat   310 FISSPKYGEGLGTVCT--GVVMENNTIIVAGEATAT-RLSRQKSKNIEIYRYHDRGNRFWEK--- 368

  Fly   372 MLCK---RSAVGVAALDDCIYVCGGYDGVTS----LNTVEVYYPKSNTWKTVAQMMKYRSAGGVT 429
             ||.   |....:.::.:.:||.||...|.:    .|.|:.|....:.||.|:.:....:...|.
  Rat   369 -LCTAEFRELYALGSIHNDLYVIGGQMKVKNQYLITNCVDKYSVDQDNWKRVSPLPLQLACHAVV 432

  Fly   430 QLNGYVYALGG-----------HDGLSIFDSVERYDQAEDVWVKMSPMLNRRCRLGVATLNGKIY 483
            .:|..:|.:||           .|.||  :.:.:||.::|.|.:.:||...:.|...|.:|.:||
  Rat   433 SVNNKLYVIGGWTPQMDLPDEEPDRLS--NKLLQYDPSQDQWRERAPMQYSKYRFSAAVVNSEIY 495

  Fly   484 VCGGY------------CGNSFLRSVECYDPQTDTWKLVTPM-----NCKRSRVALAANMGKLWA 531
            |.||.            |    |..||.|:|..|.|:...||     :.:.:..:..|..|||:.
  Rat   496 VLGGIGCLGRDKGQVRKC----LDVVEIYNPDGDFWREGPPMPSPLLSLRTNSTSAGAVDGKLYV 556

  Fly   532 IGGYDGESNLSTVEVYDPETDKW 554
            .||:.|......:.....|.|.|
  Rat   557 CGGFHGADRHEVISKEILELDPW 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	38/116 (33%)
		PHA03098	36..510	CDD:222983	150/522 (29%)
		KELCH repeat	329..372	CDD:276965	13/50 (26%)
		KELCH repeat	376..417	CDD:276965	11/44 (25%)
		KELCH repeat	423..466	CDD:276965	12/53 (23%)
		KELCH repeat	470..514	CDD:276965	18/60 (30%)
		Kelch_1	517..560	CDD:396078	10/38 (26%)
		KELCH repeat	517..560	CDD:276965	10/38 (26%)
Kbtbd12	NP_001418799.1	BTB_POZ	10..136	CDD:453885	41/135 (30%)
		PHA03098	29..586	CDD:222983	162/572 (28%)
		BACK_KBTBD12	128..226	CDD:350560	35/97 (36%)
		KELCH repeat	375..422	CDD:276965	12/46 (26%)
		KELCH repeat	426..479	CDD:276965	13/54 (24%)
		KELCH repeat	482..535	CDD:276965	18/56 (32%)
		KELCH repeat	541..587	CDD:276965	10/39 (26%)