Protein Alignment KLHL18 and enc1.2

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_001008029.1
• Gene: enc1.2 / 493391
• XenbaseID: XB-GENE-5914613
• Length: 588
• Species: Xenopus tropicalis
• Alignment Length: 554
• Identity: 155/554 - (27%)
• Similarity: 265/554 - (47%)
• Gaps: 57/554 - (10%)

  Fly    32 IRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSALESLI 96
            :|:.....||.|...:::|..|:.|||::..||.|||:..:.||:.:|:..:: |:.|..||.|:
 Frog    39 LRKRNLFTDVVLLAGNRSFPCHKAVLASSSRYFEAMFSVGLKESQDREVNFQD-ALHPEVLELLL 102

  Fly    97 NYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLIDA 161
            :|.||.::.::.:|.::|:.....||..::|||.|.||....||.|.|.:...:|:..|.:|::.
 Frog   103 DYAYSARIILNEENAESLLEAGDMLQFHDIRDAAAEFLEKNLHPANCLNMMLISDAHCCERLLEL 167

  Fly   162 ADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQV 226
            :.:....||.::|::|:||.|...:|:||:..:||.|..|.:::||.|.|:|:....|.:..|.:
 Frog   168 SWRMCLTNFVELSKTEDFLRLPKLKLMELVLSEELEVEDESLVYEAVMGWIKFDLSIRLDDLPDL 232

  Fly   227 LAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHL-MPERRGLLQSFRTRQR------ 284
            |..|||.||..|:|.. :|.:||:..:...:::::||..... :.:..|::..|..|.|
 Frog   233 LRYVRLALLPDQYLRS-LATDELVVRNKLAKEIVEEAARCRTKILQNDGVVTGFCARPRKVSQAL 296

  Fly   285 ---SGE-FFTGQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFG 345
               .|: |...:||.:.  ..|.|.:...:|..|              |.......:..|:|..|
 Frog   297 LLLGGQTFMCDKIYVMD--QKTTEIIPKTDIPSP--------------RKECSACAIGCKVYVTG 345

  Fly   346 G---FNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGV---------T 398
            |   .||..:  .|.|||...::||:..||:..|...|.|.||:|:||.||:..:         .
 Frog   346 GKGAENGASK--DVWVYDTLHDEWSKAGAMIVARFGHGSAELDNCLYVVGGHTAMAGSFPASPSV 408

  Fly   399 SLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSI----FDSVERYDQAEDV 459
            ||..||.|.|:::.|..||.:.:..|...|......::..|   |.|:    ...|:.:|..::.
 Frog   409 SLKQVEHYDPQTDKWSLVAPLREGVSNAAVVGAKLKLFVFG---GTSVNREKLPKVQCFDPLQNR 470

  Fly   460 WVKMSPMLNRRCRLGVATLNGKIYVCGG---YCGNSFLRSVECYDPQTDTWKLVTPMNCKRSRVA 521
            |...:.........|.|.|...:.|.||   :..:|..|    ::.:|..|.....::.||....
 Frog   471 WTVAATCPQPWRYTGAAVLGNDVIVVGGDTEFSASSAYR----FNSETYQWCRFGDVSSKRISCR 531

  Fly   522 LAANMGKLWAIGGYDGESNLSTVEVYDPETDKWT 555
            ..|:..:|:.:|||.|.....|::.|||.||.|:
 Frog   532 AVASGNRLYVVGGYCGAQRCKTLDCYDPSTDTWS 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	35/104 (34%)
		PHA03098	36..510	CDD:222983	139/503 (28%)
		KELCH repeat	329..372	CDD:276965	13/45 (29%)
		KELCH repeat	376..417	CDD:276965	17/49 (35%)
		KELCH repeat	423..466	CDD:276965	8/46 (17%)
		KELCH repeat	470..514	CDD:276965	10/46 (22%)
		Kelch_1	517..560	CDD:396078	14/39 (36%)
		KELCH repeat	517..560	CDD:276965	14/39 (36%)
enc1.2	NP_001008029.1	BTB_POZ	6..152	CDD:453885	39/113 (35%)
		PHA03098	48..574	CDD:222983	153/545 (28%)
		KELCH repeat	329..373	CDD:276965	13/45 (29%)
		KELCH repeat	377..430	CDD:276965	19/52 (37%)
		KELCH repeat	433..479	CDD:276965	8/48 (17%)
		KELCH repeat	481..572	CDD:276965	25/89 (28%)