Protein Alignment KLHL18 and keap1

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_001008024.1
• Gene: keap1 / 493386
• XenbaseID: XB-GENE-957785
• Length: 613
• Species: Xenopus tropicalis
• Alignment Length: 570
• Identity: 206/570 - (36%)
• Similarity: 308/570 - (54%)
• Gaps: 56/570 - (9%)

  Fly     6 NSQVEDQYFVYKHDKLFGESFPLFKEIRRMGKLCDVTLKVE----DQTFSAHRVVLAATIPYFYA 66
            |...:.||.:..|.   .::|.:..|:|...:||||.|||:    ...|.||::|||::.|.|.|
 Frog    16 NGNRQFQYSLADHT---NQAFQIMNELRLGQQLCDVKLKVKYNDVQDEFVAHKIVLASSSPVFRA 77

  Fly    67 MFTNNMAESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACA 131
            ||||.:.|..::.:|::  .:.|..::.|:.:.|:..:.:..:.|.::|.||...|:.:|..||.
 Frog    78 MFTNGLRECGMETVTIE--GVHPKVMQRLLEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKACC 140

  Fly   132 SFLISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDEL 196
            .|||.:..|.|.:||.|||:.:.|.:|...|.:||...|.:|::.|||..|...||:.|:.||||
 Frog   141 DFLIQQLDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDEL 205

  Fly   197 NVRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLD 261
            |||.|..:|.||:.||||..:.|......:|.|||...|:|.||..::.|.|:::...:|:|.|.
 Frog   206 NVRCESEVFHACINWVKYDCENRRPYIQALLRAVRCHSLTPNFLQLQLQRCEILKGDSRCQDYLS 270

  Fly   262 EA-KDFHL-------------MPE---------RRGL--LQSFRTRQRSGEFFT----------- 290
            :. :|..|             :|:         |:.|  |:::  ....||:.|
 Frog   271 QIFQDLTLHKPTLPLQGRIPNVPQFIYVAGGYYRQSLSFLEAY--NPVDGEWLTLASLEMPRSGL 333

  Fly   291 ------GQIYAVGG---LASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGG 346
                  |..|||||   .....:....::.|:|:..:|.....||:.|:|||..|::|::||.||
 Frog   334 AGCVLGGLFYAVGGRNNAPDCNKDSGALDCYNPMNNQWSPCAAMSVPRNRVGAGVIDGQIYAVGG 398

  Fly   347 FNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTSLNTVEVYYPKSN 411
            .:|....::||.|||.:::|.....|..:|..||||.|:..:|..||:||...||:.|.|||:::
 Frog   399 SHGCLHHNSVERYDPERDEWHMVSPMKTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPETD 463

  Fly   412 TWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVWVKMSPMLNRRCRLGVA 476
            .||.:|.|...||..|...|:..|||:||:||....:||||||..:|.|..::||.:||..|||.
 Frog   464 EWKDIASMNIVRSGAGACALDTSVYAMGGYDGTDQLNSVERYDVEKDDWTFVAPMRHRRSALGVT 528

  Fly   477 TLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKRSRVALAANM 526
            ...|||||.|||.|::||..||||:|.||||..||.|...||.|.:|..|
 Frog   529 VHQGKIYVLGGYDGSTFLDGVECYNPATDTWTEVTQMTSGRSGVGVAITM 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	39/120 (33%)
		PHA03098	36..510	CDD:222983	191/522 (37%)
		KELCH repeat	329..372	CDD:276965	17/42 (40%)
		KELCH repeat	376..417	CDD:276965	19/40 (48%)
		KELCH repeat	423..466	CDD:276965	19/42 (45%)
		KELCH repeat	470..514	CDD:276965	26/43 (60%)
		Kelch_1	517..560	CDD:396078	5/10 (50%)
		KELCH repeat	517..560	CDD:276965	5/10 (50%)
keap1	NP_001008024.1	BTB_POZ_KLHL19_KEAP1	25..148	CDD:349557	40/127 (31%)
		PHA03098	43..560	CDD:222983	190/520 (37%)
		BACK_KLHL19_KEAP1	146..236	CDD:350533	37/89 (42%)
		KELCH repeat	330..377	CDD:276965	9/46 (20%)
		KELCH repeat	381..424	CDD:276965	17/42 (40%)
		KELCH repeat	428..471	CDD:276965	20/42 (48%)
		KELCH repeat	475..519	CDD:276965	20/43 (47%)
		KELCH repeat	522..565	CDD:276965	26/42 (62%)