Protein Alignment KLHL18 and klhl12

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_001007329.1
• Gene: klhl12 / 492362
• ZFINID: ZDB-GENE-041114-205
• Length: 564
• Species: Danio rerio
• Alignment Length: 545
• Identity: 218/545 - (40%)
• Similarity: 308/545 - (56%)
• Gaps: 7/545 - (1%)

  Fly    32 IRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSALESLI 96
            :|:...|||:||:||...|.|||:||||...||.||||:.:||.....:.::  .:..|.:|.|:
Zfish    22 LRKSNTLCDITLRVEGTDFPAHRIVLAACSDYFCAMFTSELAEKGKSFVDIQ--GLTASTMEILL 84

  Fly    97 NYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLIDA 161
            ::||:..|.:..:|||.|:..|..|||..|:.||..||.|:..|.|.||||.||::..|..|:.|
Zfish    85 DFVYTETVLVTVENVQELLPAACLLQLKGVKRACCDFLNSQLDPSNCLGIRDFAETHNCLDLMQA 149

  Fly   162 ADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQV 226
            |:.:..::||:|.|.|||:.|...::.:|::.|.:.|.:||.:|||.:.|||:...:|....|.:
Zfish   150 AELFSQKHFAEVVQQEEFMLLSQSEVEKLIKCDVIQVDSEEPVFEAVLNWVKHNRKEREPYLPDL 214

  Fly   227 LAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLLQSFRTRQRSGEFFTG 291
            |..||:|||:|:::.|.:..|.|||.|..||||:||||.|||.||.|..:||.||:.|.|.  ..
Zfish   215 LEYVRMPLLTPRYITDVIDAEPLIRCSLPCRDLVDEAKKFHLRPELRSEMQSPRTQARLGA--KE 277

  Fly   292 QIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGGFNGTERLSTV 356
            .:..:||..|....:..||.|||.|::|.....::..|..|....||.::|..||::|..|||:|
Zfish   278 VLLVIGGFGSQQSPIDIVEKYDPKTREWSFLPNIARKRRYVATVALNDRVYVIGGYDGRSRLSSV 342

  Fly   357 EVYDPRKNK---WSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTSLNTVEVYYPKSNTWKTVAQ 418
            |..|...::   |.....|..:|...|...|.|.|||.||:||.....::|.|.|..:.|..:..
Zfish   343 ECLDYTADEDGVWYSVATMNVRRGLAGATTLGDMIYVAGGFDGSRRHTSMERYDPNIDQWSMLGD 407

  Fly   419 MMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVWVKMSPMLNRRCRLGVATLNGKIY 483
            |...|...|:...:|.:|.|||:|||:|.:||||||.....|..::||.|:|...|||.||..||
Zfish   408 MQTAREGAGLVVASGLIYCLGGYDGLNILNSVERYDPHTGHWTSVTPMANKRSGAGVALLNDHIY 472

  Fly   484 VCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKRSRVALAANMGKLWAIGGYDGESNLSTVEVYD 548
            |.||:.|.:.|.|||.|:.:||.|..|..|...|..|......|:|:||.||||.|.||::|.||
Zfish   473 VVGGFDGTAHLSSVEVYNIRTDYWTTVANMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYD 537

  Fly   549 PETDKWTFMPPMCAHSGGVGAGVIR 573
            |..|.|..:..|.......|..|:|
Zfish   538 PVIDSWEVVTSMATQRCDAGVCVLR 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	43/104 (41%)
		PHA03098	36..510	CDD:222983	192/476 (40%)
		KELCH repeat	329..372	CDD:276965	15/45 (33%)
		KELCH repeat	376..417	CDD:276965	15/40 (38%)
		KELCH repeat	423..466	CDD:276965	18/42 (43%)
		KELCH repeat	470..514	CDD:276965	21/43 (49%)
		Kelch_1	517..560	CDD:396078	19/42 (45%)
		KELCH repeat	517..560	CDD:276965	19/42 (45%)
klhl12	NP_001007329.1	BTB_POZ_KLHL12_C3IP1_DKIR	8..131	CDD:349551	45/110 (41%)
		BACK_KLHL12	126..261	CDD:350527	59/134 (44%)
		Kelch	278..325	CDD:128874	13/46 (28%)
		Kelch 1	278..325		13/46 (28%)
		NanM	304..561	CDD:442289	97/256 (38%)
		KELCH repeat	315..361	CDD:276965	15/45 (33%)
		Kelch 2	327..375		15/47 (32%)
		KELCH repeat	365..408	CDD:276965	15/42 (36%)
		Kelch 3	376..422		14/45 (31%)
		KELCH repeat	412..455	CDD:276965	18/42 (43%)
		Kelch 4	423..469		23/45 (51%)
		KELCH repeat	459..503	CDD:276965	21/43 (49%)
		Kelch 5	471..516		18/44 (41%)
		KELCH repeat	506..551	CDD:276965	20/44 (45%)
		Kelch 6	518..563		20/45 (44%)