DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KLHL18 and klhl7

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	XP_012819973.1	Gene:	klhl7 / 448292	XenbaseID:	XB-GENE-971613	Length:	587	Species:	Xenopus tropicalis

Alignment Length:	558	Identity:	167/558 - (29%)
Similarity:	279/558 - (50%)	Gaps:	18/558 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SDNSQVEDQYFVYKHDKLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMF 68
            :...:.|.::...:..||......:...:|:...||||.|.|:|:...||||||||...:|..||
Frog    10 TSKKKTEKKFAAREEAKLLASFMGVMNIMRKQKTLCDVILMVQDRKIPAHRVVLAAASHFFNLMF 74

  Fly    69 TNNMAESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASF 133
            |.||.||:..|:.:|::  ||..:|.|:.:.|:.::.:::.|||:|:..|:..|:..|:..|..|
Frog    75 TTNMLESKSFEVELKDA--EPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKRMCVEF 137

  Fly   134 LISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNV 198
            |..:....|.|||...|:.:.|.:|...||.:|.|:|.:|.:::|||.||.:::..|:.:|.|.|
Frog   138 LKEQVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTV 202

  Fly   199 RTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEA 263
            |.|:.:::|.::|:||.|..|......:||.||.||:|..||:..|..|.||:.:.:|..::...
Frog   203 RAEDQVYDAAVRWLKYDEPNRQPYMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISG 267

  Fly   264 KDFHLM-PE-RRGLLQSFRTRQRSGEFFTGQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMS 326
            ..:||: || |..|::..|.|::..::   :|...|     |....:...::|....|.......
Frog   268 MRYHLLSPEDREELVEGTRPRRKKHDY---RIALFG-----GSQPQSCRYFNPKDYNWSDIRCPF 324

  Fly   327 MMRSRVGVAVLNGKLYAFGGFNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVC 391
            ..|........:..:|..|| :....:..::.|:..|:.|.........|.::...|.:..||..
Frog   325 EKRRDAACVFWDNVVYILGG-SQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTS 388

  Fly   392 GGYD-GVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSV----E 451
            ||.: |..:|...|.|..::.:|.|...|:..|.:.|:.:.||.:|..||..|.::...|    |
Frog   389 GGSEVGNNALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNCCE 453

  Fly   452 RYDQAEDVWVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCK 516
            .||.|.:.|.::.||:..|...|:..:..||:..||..|...|.|||.||.:.:.||:|:||..|
Frog   454 VYDPATESWTELCPMIEARKNHGLVFVKDKIFAIGGQNGLGGLDSVEYYDIKLNEWKMVSPMPWK 518

  Fly   517 RSRVALAANMGKLWAIGGYDGESNLSTVEVYDPETDKW 554
            ...|..||....::.:.|:.|...|..:..|:.|.|||
Frog   519 GVTVKCAAVGSVIYVLAGFQGVGRLGHILEYNTEADKW 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	40/105 (38%)
		PHA03098	36..510	CDD:222983	148/480 (31%)
		BACK	143..245	CDD:285009	38/101 (38%)
		Kelch	292..339	CDD:128874	6/46 (13%)
		KELCH repeat	329..372	CDD:276965	7/42 (17%)
		Kelch	340..386	CDD:128874	8/45 (18%)
		KELCH repeat	376..417	CDD:276965	12/41 (29%)
		Kelch	387..433	CDD:128874	13/46 (28%)
		KELCH repeat	423..466	CDD:276965	14/46 (30%)
		Kelch	435..480	CDD:128874	14/48 (29%)
		Kelch_1	469..514	CDD:279660	17/44 (39%)
		KELCH repeat	470..514	CDD:276965	17/43 (40%)
		Kelch_1	517..560	CDD:279660	11/38 (29%)
		KELCH repeat	517..560	CDD:276965	11/38 (29%)
klhl7	XP_012819973.1	BTB_POZ_KLHL7	24..149	CDD:349546	44/126 (35%)
		PHA03098	38..556	CDD:222983	162/528 (31%)
		BACK_KLHL7	141..238	CDD:350522	34/96 (35%)
		KELCH repeat	327..370	CDD:276965	7/43 (16%)
		KELCH repeat	373..417	CDD:276965	12/43 (28%)
		KELCH repeat	421..469	CDD:276965	15/47 (32%)
		KELCH repeat	472..516	CDD:276965	17/43 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920