DRSC/TRiP Functional Genomics Resources

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Protein Alignment KLHL18 and Keap1

DIOPT Version :9

Sequence 1:NP_001262494.1 Gene:KLHL18 / 41458 FlyBaseID:FBgn0037978 Length:575 Species:Drosophila melanogaster
Sequence 2:NP_732202.2 Gene:Keap1 / 42062 FlyBaseID:FBgn0038475 Length:776 Species:Drosophila melanogaster


Alignment Length:568 Identity:204/568 - (35%)
Similarity:305/568 - (53%) Gaps:55/568 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 LSDNSQVEDQ--YFVYKHDKLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFY 65
            |.|:...:|.  :.:..:.|   |:..:...:|..|.|.||.|:|:.:.|.||:|||:|..|||.
  Fly    55 LDDHDATDDDMTFCMSNYAK---EALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFK 116

  Fly    66 AMFTNNMAESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDAC 130
            ||||..:.||.:..:.::  .:.|:|:..::.::|:||:|:....|..|:..|:..|:.||.|||
  Fly   117 AMFTGGLKESEMSRVQLQ--GVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDAC 179

  Fly   131 ASFLISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDE 195
            .:||..:..|.|.:||..||:...|.:|...|:.:|::||.:|.|.||||.|...||:.|:||||
  Fly   180 CAFLERQLDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDE 244

  Fly   196 LNVRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLL 260
            |||:.|..::.|.:|||||.||.|......:|.|||...|:|.||.:::...:::|....||:.|
  Fly   245 LNVQEEREVYNAVLKWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYL 309

  Fly   261 DEAKDF-----HLMP---ERR------------------GLLQSFRTRQ------------RSG- 286
              ||.|     |..|   ||.                  .:|:::....            ||| 
  Fly   310 --AKIFKDLTLHKCPGVKERTPNTTRMIFVAGGFFRHSLDILEAYNVDDMTWTTLANLRIPRSGL 372

  Fly   287 --EFFTGQIYAVGG----LASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFG 345
              .|..|:.|||||    :.|:.:| ..|:.|..:|:.|:....||:.|.||||||::..:||.|
  Fly   373 GAAFLKGKFYAVGGRNNNIGSSYDS-DWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVG 436

  Fly   346 GFNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTSLNTVEVYYPKS 410
            |..|.|..:|||.|||..::|:....|..||..|||..::..:|..||:||...|.:||.|:|::
  Fly   437 GSAGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPEN 501

  Fly   411 NTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVWVKMSPMLNRRCRLGV 475
            |.|..:..:...||..||..:|.|:|.:||.||.....:|||||...|.|..::|:...|..|.:
  Fly   502 NEWSFLPPLQTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQIARSALSL 566

  Fly   476 ATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKRSRVALA 523
            ..|:.|:|..||:.||:||..||.|||:|:||...||:...||..|.|
  Fly   567 TPLDEKLYAIGGFDGNNFLSIVEVYDPRTNTWTTGTPLKSGRSGHASA 614

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KLHL18NP_001262494.1 BTB 29..135 CDD:279045 39/105 (37%)
PHA03098 36..510 CDD:222983 192/518 (37%)
BACK 143..245 CDD:285009 45/101 (45%)
Kelch 292..339 CDD:128874 20/50 (40%)
KELCH repeat 329..372 CDD:276965 20/42 (48%)
Kelch 340..386 CDD:128874 19/45 (42%)
KELCH repeat 376..417 CDD:276965 16/40 (40%)
Kelch 387..433 CDD:128874 16/45 (36%)
KELCH repeat 423..466 CDD:276965 18/42 (43%)
Kelch 435..480 CDD:128874 16/44 (36%)
Kelch_1 469..514 CDD:279660 21/44 (48%)
KELCH repeat 470..514 CDD:276965 21/43 (49%)
Kelch_1 517..560 CDD:279660 4/7 (57%)
KELCH repeat 517..560 CDD:276965 4/7 (57%)
Keap1NP_732202.2 BTB 80..183 CDD:279045 38/104 (37%)
PHA03098 92..599 CDD:222983 188/511 (37%)
BACK 192..294 CDD:285009 45/101 (45%)
Kelch 335..379 CDD:128874 5/43 (12%)
KELCH repeat 369..416 CDD:276965 16/47 (34%)
Kelch 382..430 CDD:128874 20/48 (42%)
KELCH repeat 420..463 CDD:276965 20/42 (48%)
Kelch 433..476 CDD:128874 19/42 (45%)
KELCH repeat 467..510 CDD:276965 16/42 (38%)
Kelch 478..523 CDD:128874 16/44 (36%)
KELCH repeat 514..558 CDD:276965 19/43 (44%)
Kelch_1 514..556 CDD:279660 18/41 (44%)
KELCH repeat 561..606 CDD:276965 21/44 (48%)
Kelch 572..616 CDD:128874 22/43 (51%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45464359
Domainoid 1 1.000 52 1.000 Domainoid score I4252
eggNOG 1 0.900 - - E1_KOG4441
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 57 1.000 Inparanoid score I2576
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D26788at33392
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm2846
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR24412
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X9
98.900

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