Protein Alignment KLHL18 and klhl20

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_998166.2
• Gene: klhl20 / 406274
• ZFINID: ZDB-GENE-040426-1935
• Length: 591
• Species: Danio rerio
• Alignment Length: 565
• Identity: 253/565 - (44%)
• Similarity: 348/565 - (61%)
• Gaps: 14/565 - (2%)

  Fly    16 YKHDKLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEI 80
            |..||...::..:...:|:..:||||.|.|..:...||||:|:|..|||.||||..:||||..|:
Zfish    27 YISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEV 91

  Fly    81 TMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLG 145
            .:::  |:..|:|.||::.|:.||.::..|||.|:..|..|||:.:::||..||..:..|.|.||
Zfish    92 VIRD--IDERAMELLIDFAYTSQVTVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLG 154

  Fly   146 IRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMK 210
            ||.|||:..||:|:..|||:...||.:|.:||||:.|...||::::..||||||:||.:|.|.|.
Zfish   155 IRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMA 219

  Fly   211 WVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGL 275
            ||||:..:|....||||..||||||||:||...|..:.||:|..:||||:||||::.|:|:.|.|
Zfish   220 WVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNYLLLPQERPL 284

  Fly   276 LQSFRTRQRS----GEFFTGQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAV 336
            :|..|||.|.    ||.    ::||||..| |:::|:||.|||.|.:|:|...||..|..|||:|
Zfish   285 MQGPRTRPRKPIRCGEV----LFAVGGWCS-GDAISSVERYDPQTNEWRMVASMSKRRCGVGVSV 344

  Fly   337 LNGKLYAFGGFNGTERLSTVEVYDPRKNKWSQGCA--MLCKRSAVGVAALDDCIYVCGGYDGVTS 399
            |:..|||.||.:|:..|::||.|||:.|:||...|  ..| |::||||.|...:|..||.|||:.
Zfish   345 LDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTC-RTSVGVAVLGGYLYAVGGQDGVSC 408

  Fly   400 LNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVWVKMS 464
            ||.||.|.||.|.|..||.|...|....|..|.|::||:||.||.|..::||||:..|:.|..::
Zfish   409 LNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTVA 473

  Fly   465 PMLNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKRSRVALAANMGKL 529
            ||..||..||.|.....||..||....:.|.|.|.|:|:|:.|..|..|..:||.|.||...|:|
Zfish   474 PMGTRRKHLGCAVYQDMIYSVGGRDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQL 538

  Fly   530 WAIGGYDGESNLSTVEVYDPETDKWTFMPPMCAHSGGVGAGVIRI 574
            .|:||:||.:.|.|:|||||:.:.|.....|.....|.|.|||::
Zfish   539 MAVGGFDGTTYLKTIEVYDPDANTWRLYGGMNYRRLGGGVGVIKM 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	46/116 (40%)
		PHA03098	36..510	CDD:222983	221/479 (46%)
		KELCH repeat	329..372	CDD:276965	22/44 (50%)
		KELCH repeat	376..417	CDD:276965	21/40 (53%)
		KELCH repeat	423..466	CDD:276965	17/42 (40%)
		KELCH repeat	470..514	CDD:276965	16/43 (37%)
		Kelch_1	517..560	CDD:396078	20/42 (48%)
		KELCH repeat	517..560	CDD:276965	20/42 (48%)
klhl20	NP_998166.2	None