Protein Alignment KLHL18 and KLHL31

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_001003760.2
• Gene: KLHL31 / 401265
• HGNCID: 21353
• Length: 634
• Species: Homo sapiens
• Alignment Length: 542
• Identity: 152/542 - (28%)
• Similarity: 263/542 - (48%)
• Gaps: 28/542 - (5%)

  Fly    31 EIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSALESL 95
            ::|:...|||:.:..:.::|..|:.|:|:...|||.:...   :..|:.:.:.:  |.|..|.::
Human    65 KMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKK---DPSIQRVDLND--ISPLGLATV 124

  Fly    96 INYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLID 160
            |.|.|:|::.:....:.:::..|.:||:..:...|:.|||......|.:.:...|::...:....
Human   125 IAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREMSVENCMYVVNIAETYSLKNAKA 189

  Fly   161 AADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQ 225
            ||.|:|..||.:.::|::|:.|..||:.||:..|:|.:.:|.|.|:..|||::: :.||.:....
Human   190 AAQKFIRDNFLEFAESDQFMKLTFEQINELLIDDDLQLPSEIVAFQIAMKWLEF-DQKRVKYAAD 253

  Fly   226 VLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLLQSFRTRQRSGEFFT 290
            :|:.:|...:|.|.|.:.|.....:.....|..||.:|.::||:|..:..|||.|||.|.|   .
Human   254 LLSNIRFGTISAQDLVNYVQSVPRMMQDADCHRLLVDAMNYHLLPYHQNTLQSRRTRIRGG---C 315

  Fly   291 GQIYAVGGLAS-TGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGGFNGTE--- 351
            ..:..|||... |.:|:|...:|......|....:|........|||::|.||..||.:..:
Human   316 RVLVTVGGRPGLTEKSLSRDILYRDPENGWSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQNDARN 380

  Fly   352 ----RLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTSLNTVEVYYPKSNT 412
                .:|....||||.|.|....:|..||:...::..:..:|..||.:...||.::|.|.|.:|.
Human   381 QAKHAVSNFCRYDPRFNTWIHLASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQ 445

  Fly   413 W--KTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVWVKMSPMLNRRCRLGV 475
            |  ||..::.:...|..|.  :|.|...||:...:...||..||.|.|.|.::..:...|.....
Human   446 WQPKTPLEVARCCHASAVA--DGRVLVTGGYIANAYSRSVCAYDPASDSWQELPNLSTPRGWHCA 508

  Fly   476 ATLNGKIYVCGG-YCGNSFLR----SVECYDPQTDTWKLVTPMNCKRSRVALAANMGKLWAIGGY 535
            .||:.::||.|| ..|....|    :||||.|.|..|....|:....|...::|..|:.:.:||:
Human   509 VTLSDRVYVMGGSQLGPRGERVDVLTVECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGW 573

  Fly   536 -DGESNL-STVEVYDPETDKWT 555
             :||... ..::.:.||.::||
Human   574 NEGEKKYKKCIQCFSPELNEWT 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	26/105 (25%)
		PHA03098	36..510	CDD:222983	139/488 (28%)
		KELCH repeat	329..372	CDD:276965	15/49 (31%)
		KELCH repeat	376..417	CDD:276965	13/42 (31%)
		KELCH repeat	423..466	CDD:276965	13/42 (31%)
		KELCH repeat	470..514	CDD:276965	17/48 (35%)
		Kelch_1	517..560	CDD:396078	11/41 (27%)
		KELCH repeat	517..560	CDD:276965	11/41 (27%)
KLHL31	NP_001003760.2	BTB_POZ_KLHL31_KBTBD1	55..174	CDD:349569	27/113 (24%)
		PHA03098	73..601	CDD:222983	150/534 (28%)
		BACK_KLHL31_KBTBD1	167..264	CDD:350545	27/97 (28%)
		Kelch 1	317..365		12/47 (26%)
		KELCH repeat	356..405	CDD:276965	15/48 (31%)
		Kelch 2	366..419		14/52 (27%)
		KELCH repeat	409..453	CDD:276965	13/43 (30%)
		Kelch 3	420..466		14/47 (30%)
		KELCH repeat	456..501	CDD:276965	13/46 (28%)
		Kelch 4	468..513		13/44 (30%)
		KELCH repeat	503..551	CDD:276965	16/47 (34%)
		Kelch 5	515..565		16/49 (33%)
		KELCH repeat	555..602	CDD:276965	11/41 (27%)
		Kelch 6	567..614		8/29 (28%)