DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KLHL18 and klhl41

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_989214.1	Gene:	klhl41 / 394822	XenbaseID:	XB-GENE-5850464	Length:	606	Species:	Xenopus tropicalis

Alignment Length:	629	Identity:	153/629 - (24%)
Similarity:	266/629 - (42%)	Gaps:	104/629 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LSDNSQVEDQYFVYK----HDKLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPY 63
            :....:::|:..:|:    .|.|        ||:....|..|..||...::...||::|||..||
Frog     1 MDPTGEIKDELRLYQSTLLQDGL--------KELLDENKFVDCFLKAGSKSLPCHRLILAACSPY 57

  Fly    64 FYAMFTNNMAESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRD 128
            |...|.::  ||..|:..|:...:|||.:|:::.|:||..:.:::.|||::...||..|:.:|..
Frog    58 FREFFLSD--ESEEKKKNMELDNVEPSTMEAILKYLYSADIDLNDGNVQDIFALASRFQIPSVFT 120

  Fly   129 ACASFLISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRR 193
            .|.::|..|..|.|.|.|......:.|.:|...|..|:...|.::...|:||.|...:|:.::..
Frog   121 VCVTYLQRRLSPANCLAIFRLGLLLDCPRLAVTARDYVCDRFMQICNEEDFLQLAPHELIAVISS 185

  Fly   194 DELNVRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRD 258
            |.|||..||::|||.||||:..::.:::....|...:|..|:..::..|:|.:.:||:::   .|
Frog   186 DGLNVEKEELVFEAVMKWVQTDKENKTKSLSDVFDCIRFRLMPEKYFTDKVEKHDLIKAN---PD 247

  Fly   259 LLDEAK------------------------------DFHLMPERRGLLQSFRTRQRSGEFFTGQI 293
            ::.:.|                              |..|:|   |.|...   .|.|.|....:
Frog   248 IVKKVKVIKDAFAGKLPEGSKGKENSGKEGEDGDVGDEDLLP---GYLNDI---PRHGMFVKDLM 306

  Fly   294 YAVGGLASTGESVSTVEIYDPLTKK-WKMGEQMSMMRSRVGVAVLNGKLYAFGGFNGTERLSTVE 357
            ..|...|:..        ||||..: :.:|....:.|:...:...:.::|..||
Frog   307 LLVSDTAAVA--------YDPLENECFLVGLSEQIPRNHSSIVTKSNQVYVIGG----------- 352

  Fly   358 VYDPRKNK-----------------WSQGCAMLCKRSAVGVAALDDCIYVCGGYD--GVTSLNTV 403
            :|...:||                 |.....:...|...|:...|||:|...|.|  ...||::|
Frog   353 LYVDEENKDQPLHSYFFQLDSIAGDWIGLPPLPSARCLFGLGEADDCVYAIAGRDLQSEESLDSV 417

  Fly   404 EVYYPKSNTWKTVAQM-MKYRSAGGVTQLNGYVYALGGH-DGLSIFDSVERYDQAEDVWVKMSPM 466
            ..|..|:..|..|.:: :|......|:. |..:|.|||. :.......:..::..:..|..:.||
Frog   418 FCYDSKAVAWTEVKKLPIKVYGHSAVSH-NSQIYCLGGKTEDKKCTGRMFVFNPKKGEWKDLPPM 481

  Fly   467 LNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKRSRVALAANMGKLWA 531
            ...|...||....|||:|.||........|||.||..|:.|:.:.....:||.:.|.:..|.|:|
Frog   482 RTSRSMFGVTVHKGKIFVVGGVTEEGLTASVEAYDIATNKWETLAEFPQERSSINLVSVGGSLYA 546

  Fly   532 IGGYD---------GESNLSTVEVYDPETDKWTFMPPMCAHSGG 566
            :||:.         ..:.::.|..|:.:..:|:.|.....::.|
Frog   547 VGGFAMIQLESKEFAPTEVTDVWKYEDDKKEWSGMLKELRYAAG 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	34/105 (32%)
		PHA03098	36..510	CDD:222983	134/525 (26%)
		BACK	143..245	CDD:285009	29/101 (29%)
		Kelch	292..339	CDD:128874	8/47 (17%)
		KELCH repeat	329..372	CDD:276965	8/59 (14%)
		Kelch	340..386	CDD:128874	9/62 (15%)
		KELCH repeat	376..417	CDD:276965	14/42 (33%)
		Kelch	387..433	CDD:128874	13/48 (27%)
		KELCH repeat	423..466	CDD:276965	7/43 (16%)
		Kelch	435..480	CDD:128874	10/45 (22%)
		Kelch_1	469..514	CDD:279660	16/44 (36%)
		KELCH repeat	470..514	CDD:276965	16/43 (37%)
		Kelch_1	517..560	CDD:279660	12/51 (24%)
		KELCH repeat	517..560	CDD:276965	12/51 (24%)
klhl41	NP_989214.1	BTB	47..579	CDD:333434	140/562 (25%)
		KELCH repeat	388..433	CDD:276965	15/44 (34%)
		KELCH repeat	437..482	CDD:276965	8/45 (18%)
		KELCH repeat	485..530	CDD:276965	16/44 (36%)
		KELCH repeat	532..579	CDD:276965	10/46 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000