DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KLHL18 and klhl6

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_001005316.2	Gene:	klhl6 / 368818	ZFINID:	ZDB-GENE-030616-325	Length:	614	Species:	Danio rerio

Alignment Length:	588	Identity:	177/588 - (30%)
Similarity:	260/588 - (44%)	Gaps:	114/588 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSALESLINYVYSG 102
            |.||.|.|:.|:|..|||||||...||.|||.|::.|...:.:.:|  .|:...:..|::|.|:.
Zfish    64 LTDVILNVQSQSFKCHRVVLAAASHYFRAMFCNDLREKHEENVNIK--GIDADTMRILLDYTYTS 126

  Fly   103 QVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLIDAADKYID 167
            :|.|...|||.::..|...|...:.|||||:|....||.|.:||...||......|......||.
Zfish   127 KVTITKDNVQRMLEAACLFQFPRIVDACASYLAEALHPENCVGILHLADVHSLESLKTQVHSYIV 191

  Fly   168 QNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRL 232
            |||::|...||.|.|..:.|:.|::.|:|.|..||.:|:..::|||..||.|:.|.|:||..|||
Zfish   192 QNFSQVVDHEEILELPADVLVSLIQHDDLGVTEEEQVFDTVIRWVKAREDDRTALLPRVLTHVRL 256

  Fly   233 PLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLLQSFRTRQRSGEFFTGQIYAVG 297
            |||.|.|..:||..:.|||...:...||.||:.:||..:.   :.|.||:.|..||.:.....:|
Zfish   257 PLLDPWFFVERVEGDPLIRHCAEVFPLLQEARVYHLSGKE---VISERTKPRVQEFQSEVFMIIG 318

  Fly   298 GLASTGESVSTVEIYDPLTK--------------------------------------------- 317
            |.....:.||.|...|||.:
Zfish   319 GCTKEEKFVSEVTCLDPLRRSRLEVAKLPNTEMETESENKKWVEFACVTFRNEVYISGGKETLHD 383

  Fly   318 ---------KWKMGEQMSMMRSRVGVAVLNGKLYAFGGFNGTERLSTVEVYDPRKNKWSQGCAML 373
                     ||...|.::..|.|..:||..||:|..|||:||:||:.||.|||..|.||:...::
Zfish   384 VWKYNASLNKWIQIEFLNTGRWRHKMAVAGGKVYVLGGFDGTQRLNCVEAYDPFHNCWSEAAPLM 448

  Fly   374 CKRSAVGVAALDDCIYVCGGYDGVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYAL 438
            ...|:...|:.|.||||.|
Zfish   449 LSVSSFSAASFDRCIYVIG---------------------------------------------- 467

  Fly   439 GGHDGLSIFDSVERYDQAEDVWVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECYDPQ 503
            ||.:|....::::.:|...:.|....||..........|....|:|.||     .::::..|.|.
Zfish   468 GGPNGKLATNNMQCFDSQSNKWSLKCPMPTEAKCTNAVTFKDAIFVVGG-----AMKALYSYSPL 527

  Fly   504 TDTWKLVTPMNCKRSRVALAANMGKLWAIGGYDGESN-LSTVEVYDPETDKWT---FMPPMCAHS 564
            .|:|.|:..:.|:|:...:||...||:..||.|.::. ::||..::|:|.|.|   .:|...:|.
Zfish   528 VDSWTLIIQLGCERASCGIAACNNKLFITGGRDDKNEVIATVLCWNPDTKKLTEECVLPRGVSHH 592

  Fly   565 GGV 567
            |.|
Zfish   593 GSV 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	38/96 (40%)
		PHA03098	36..510	CDD:222983	157/525 (30%)
		BACK	143..245	CDD:285009	42/101 (42%)
		Kelch	292..339	CDD:128874	15/100 (15%)
		KELCH repeat	329..372	CDD:276965	22/42 (52%)
		Kelch	340..386	CDD:128874	19/45 (42%)
		KELCH repeat	376..417	CDD:276965	8/40 (20%)
		Kelch	387..433	CDD:128874	5/45 (11%)
		KELCH repeat	423..466	CDD:276965	5/42 (12%)
		Kelch	435..480	CDD:128874	8/44 (18%)
		Kelch_1	469..514	CDD:279660	10/44 (23%)
		KELCH repeat	470..514	CDD:276965	10/43 (23%)
		Kelch_1	517..560	CDD:279660	15/46 (33%)
		KELCH repeat	517..560	CDD:276965	15/46 (33%)
klhl6	NP_001005316.2	BTB	55..158	CDD:279045	38/95 (40%)
		PHA03098	67..565	CDD:222983	165/553 (30%)
		BACK	167..269	CDD:285009	42/101 (42%)
		KELCH repeat	363..400	CDD:276965	3/36 (8%)
		Kelch_1	363..397	CDD:279660	2/33 (6%)
		KELCH repeat	404..448	CDD:276965	22/43 (51%)
		Kelch_1	406..448	CDD:279660	21/41 (51%)
		KELCH repeat	451..497	CDD:276965	15/91 (16%)
		Kelch	462..507	CDD:128874	12/90 (13%)
		KELCH repeat	499..534	CDD:276965	9/39 (23%)
		KELCH repeat	541..585	CDD:276965	14/43 (33%)
		Kelch_6	541..581	CDD:290672	13/39 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810