Protein Alignment KLHL18 and Klhl14

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_001102355.1
• Gene: Klhl14 / 364823
• RGDID: 1566178
• Length: 630
• Species: Rattus norvegicus
• Alignment Length: 600
• Identity: 152/600 - (25%)
• Similarity: 251/600 - (41%)
• Gaps: 90/600 - (15%)

  Fly    39 CDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNN--------------------------MAESRI 77
            |||||..:.|.|..|:.|||:...||.::|:::                          ...|:.
  Rat    33 CDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPLGGGVGGQDGLGAPKDQQQQQQPQQQPSQQ 97

  Fly    78 KEITMKESAIEPSA-------------------------LESLINYVYSGQVRIDNQNVQNLMVG 117
            ::...:|....||:                         |..::.|:|:..|.:....|:.::..
  Rat    98 QQQPPQEEPGTPSSSPDDKLLTSPRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSV 162

  Fly   118 ASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLAL 182
            :..|.:..|...|..||..:....|...:...|......:....|:||:         .|:.|.|
  Rat   163 SKILHIPQVTKLCVQFLNDQISVQNYKQVCKIAALHGLEETKKLANKYL---------VEDVLLL 218

  Fly   183 DCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVARE 247
            :.|::..|:......|.:|..:|:..:.|:::..:.|.:..|.::..:|..|:....|.:||...
  Rat   219 NFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSV 283

  Fly   248 ELIRSSHQCRDLLDEAKDFHLMPERRGLLQSFRTRQRSGEFFTGQIYAVGGLASTGESV--STVE 310
            :.:|:...|:.||.:|.::||||.|:...||..:|.||.:   ..:..||||....:.:  :.|:
  Rat   284 DFMRTDPVCQKLLLDAMNYHLMPFRQHCRQSLASRIRSNK---KMLLLVGGLPPGPDRLPSNLVQ 345

  Fly   311 IYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGGF-----NGTERLSTVEVYDPRKNKWSQGC 370
            .||...|.||:...|....:...|..:...|:..||.     ||....:.|..||||.|.|.|..
  Rat   346 YYDDEKKTWKILTIMPYNSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLP 410

  Fly   371 AMLCKRSAVGVAALDDCIYVCGGYDGVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYV 435
            .|..:|::.....||..:||.||.:....|::||.|...:|.|:.|:.:.:..:|......||.:
  Rat   411 PMQERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLDTNEWRYVSSLPQPLAAHAGAVHNGKI 475

  Fly   436 YALGG-HDGLSIFDSVERYDQAEDVWVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSF----LR 495
            |..|| |:| .....:..||...|||.:...|..:|....:|.:|.::|..||.....|    :.
  Rat   476 YISGGVHNG-EYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVM 539

  Fly   496 SVECYDPQTDTWKLV-TPMNCKRSRVALAANMGKLWAIGGYD---GESNLSTVEVYDPETDKWTF 556
            .||||||:.|.|.:: ||:...||....|.....::.:|||.   |....||: .|.||...||.
  Rat   540 LVECYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTI-CYCPEKGTWTE 603

  Fly   557 MP---------PMCA 562
            :.         |.||
  Rat   604 LEGDVAEPLAGPACA 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	28/148 (19%)
		PHA03098	36..510	CDD:222983	133/533 (25%)
		KELCH repeat	329..372	CDD:276965	14/47 (30%)
		KELCH repeat	376..417	CDD:276965	13/40 (33%)
		KELCH repeat	423..466	CDD:276965	13/43 (30%)
		KELCH repeat	470..514	CDD:276965	17/48 (35%)
		Kelch_1	517..560	CDD:396078	14/54 (26%)
		KELCH repeat	517..560	CDD:276965	14/54 (26%)
Klhl14	NP_001102355.1	BTB_POZ_KLHL14_printor	1..190	CDD:349552	29/156 (19%)
		BACK_KLHL14	183..284	CDD:350528	21/109 (19%)
		NanM	326..579	CDD:442289	74/253 (29%)
		KELCH repeat	365..412	CDD:276965	14/46 (30%)
		KELCH repeat	416..460	CDD:276965	14/43 (33%)
		KELCH repeat	463..508	CDD:276965	14/45 (31%)
		Kelch_1	562..604	CDD:396078	14/42 (33%)
		KELCH repeat	562..604	CDD:276965	14/42 (33%)