DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KLHL18 and kel-8

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_001300209.1	Gene:	kel-8 / 3565011	WormBaseID:	WBGene00020952	Length:	727	Species:	Caenorhabditis elegans

Alignment Length:	579	Identity:	187/579 - (32%)
Similarity:	289/579 - (49%)	Gaps:	29/579 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 YKHDKLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEI 80
            |::.:...:.....:.:|:..:||||.|.|......|||.:|||..|||.|||||.|.|  :|::
Worm   125 YENQEQSSKIMEQMRILRQTEELCDVELLVAGSVIRAHRYILAAASPYFKAMFTNGMVE--MKKL 187

  Fly    81 TMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLG 145
            |::...|...::..:::|:|:.::.|...||..|:..|:.||:..:..||..||.:....||.:.
Worm   188 TIELQDIPEESVRIIVDYIYTDKIAITMNNVHQLIFTATVLQMDVIVVACQQFLATMITSHNCMS 252

  Fly   146 IRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMK 210
            :..|:|...|..||.:.:.:....|..:.:|.||.::....|..|:.|.:|||..|:.:||..::
Worm   253 LYHFSDIYNCTNLISSIEDFASSQFRCIRKSPEFNSISFHHLKSLLNRSDLNVSEEQDVFETIVQ 317

  Fly   211 WVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGL 275
            ||......|...|.|:...:||.|:...||.:.|.....:::|.:||:::.......:.|.:|..
Worm   318 WVSSNPRDRQHHFVQLFKTLRLHLVGWNFLCEAVNSNSYVKNSQECREIISAMVLDAMTPSKRKH 382

  Fly   276 LQSFRTRQRSGEF-----------------------FTGQIYAVGGLASTGESVSTVEIYDPLTK 317
            .:|  ..:.:.|:                       ..|.|:..||....|...|:||.||....
Worm   383 PES--NHENTSEYSASMACPSLTASSSSSTSTFRKSVAGAIFCAGGRGKAGGPFSSVEAYDWRRN 445

  Fly   318 KWKMGEQMSMMRSRVGVAVLNGKLYAFGGFNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVA 382
            :|.....|...|..|||...||.|||.||.:||..|:|.|.:.|...:|.:..:|...|..:.||
Worm   446 QWIEVPDMMSQRRHVGVVSANGNLYAIGGHDGTAHLATAEAFQPSIRQWKRIASMKTARRGIAVA 510

  Fly   383 ALDDCIYVCGGYDGVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIF 447
            ::::.||..||.|..|...|||.|..:.:.|.|||.|...|...||..:..|::|:||:||.|..
Worm   511 SIENVIYAVGGLDDTTCYKTVERYDIEEDEWSTVADMDVQRGGVGVAVIGRYLFAIGGNDGTSSL 575

  Fly   448 DSVERYDQAEDVWVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTP 512
            ::.||:|...|.|.:::.|.|||...||..|:|.:|..||:..|:.|.:.|.|||..|.|..:..
Worm   576 ETCERFDPMIDKWKRIASMKNRRAGSGVCVLDGYLYAIGGFDDNAPLETCERYDPDADKWITLDK 640

  Fly   513 MNCKRSRVALAANMGKLWAIGGYDGESNLSTVEVYDPETDKWTFMPPMCAHSGGVGAGV 571
            |:..|..|.:||..||::||||:||...|:|||.|||..::|  .|.........||||
Worm   641 MSSPRGGVGVAALGGKVYAIGGHDGSDYLNTVECYDPIANRW--QPAAEIKECRAGAGV 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	38/105 (36%)
		PHA03098	36..510	CDD:222983	159/496 (32%)
		BACK	143..245	CDD:285009	28/101 (28%)
		Kelch	292..339	CDD:128874	15/46 (33%)
		KELCH repeat	329..372	CDD:276965	18/42 (43%)
		Kelch	340..386	CDD:128874	16/45 (36%)
		KELCH repeat	376..417	CDD:276965	15/40 (38%)
		Kelch	387..433	CDD:128874	18/45 (40%)
		KELCH repeat	423..466	CDD:276965	15/42 (36%)
		Kelch	435..480	CDD:128874	18/44 (41%)
		Kelch_1	469..514	CDD:279660	17/44 (39%)
		KELCH repeat	470..514	CDD:276965	16/43 (37%)
		Kelch_1	517..560	CDD:279660	21/42 (50%)
		KELCH repeat	517..560	CDD:276965	21/42 (50%)
kel-8	NP_001300209.1	PHA03098	148..635	CDD:222983	157/490 (32%)
		KELCH repeat	457..500	CDD:276965	18/42 (43%)
		KELCH repeat	504..547	CDD:276965	17/42 (40%)
		KELCH repeat	551..595	CDD:276965	15/43 (35%)
		KELCH repeat	598..643	CDD:276965	17/44 (39%)
		KELCH repeat	645..687	CDD:276965	21/43 (49%)
		Kelch	656..698	CDD:128874	20/44 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820