DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KLHL18 and KLHL38

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_001075144.2	Gene:	KLHL38 / 340359	HGNCID:	34435	Length:	581	Species:	Homo sapiens

Alignment Length:	559	Identity:	154/559 - (27%)
Similarity:	247/559 - (44%)	Gaps:	94/559 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LFKE-------------IRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKE 79
            |||:             :|:...|.||::....:....||.|||::.|||.|||.::..|....:
Human    10 LFKDHDFSSDLLRQLNSLRQSRILTDVSICAGAREIPCHRNVLASSSPYFRAMFCSSFREKSEAK 74

  Fly    80 ITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVL 144
            :.:|  .|:|..|:.:::|||:|:..|...||..:|..||.||...:.:||:|:|.|:..|.|.|
Human    75 VQLK--GIDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEACSSYLQSQLAPSNCL 137

  Fly   145 GIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELN----VRTEEVIF 205
            |:...::.:.|..|...|.:....:|.:|:.|     .|.::|..|..||.|.    ...||.:|
Human   138 GMIRLSEILSCETLKKKAREVALTSFPEVAAS-----ADLKELCALELRDYLGDDGLCGEEEKVF 197

  Fly   206 EACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKD----- 265
            ||.|.|:|:....|.....::...|||..:.|.|....:|.:.|::||..|:.:|:.||.
Human   198 EALMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDALLQSSPACQIILETAKRQMFSL 262

  Fly   266 -----------FHLMPERRGLLQSF--------RTRQRSGEFF-----TGQ-------------- 292
                       .|:.|  |...|.|        .::|.:.:..     |||
Human   263 CGTTVPDCKLLLHVPP--RNSYQDFLILLGGRKDSQQTTRDVLLYSKQTGQWQSLAKLPTRLYKA 325

  Fly   293 --------IYAVGGLA-STGESV--STVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGG 346
                    ||.:||:| |:|.|:  ..|.|:.....:|::||.|.:.|...........:::.||
Human   326 SAITLHRSIYVLGGMAVSSGRSLVSHNVYIFSLKLNQWRLGEPMLVARYSHRSTAHKNFIFSIGG 390

  Fly   347 F-NGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTS-LNTVEVYYPK 409
            . .|.|.:.::|.||...|.|....:|........||..|..:|:.||.|.:.: :..::||:..
Human   391 IGEGQELMGSMERYDSICNVWESMASMPVGVLHPAVAVKDQRLYLFGGEDIMQNPVRLIQVYHIS 455

  Fly   410 SNTW-KTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVWVKMSPMLNRRCRL 473
            .|:| |...:|:|...|..|. |...:..:||:.     ..:..||...:.:||.:.|.:||...
Human   456 RNSWFKMETRMIKNVCAPAVV-LGERIVIVGGYT-----RRILAYDPQSNKFVKCADMKDRRMHH 514

  Fly   474 GVATLNGKIYVCGGY-----CGNSFLRSVECYDPQTDTW 507
            |...:..|:||.||.     |......|.:||||:||||
Human   515 GATVMGNKLYVTGGRRLTTDCNIEDSASFDCYDPETDTW 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	37/118 (31%)
		PHA03098	36..510	CDD:222983	150/538 (28%)
		BACK	143..245	CDD:285009	28/105 (27%)
		Kelch	292..339	CDD:128874	16/71 (23%)
		KELCH repeat	329..372	CDD:276965	10/43 (23%)
		Kelch	340..386	CDD:128874	12/46 (26%)
		KELCH repeat	376..417	CDD:276965	12/42 (29%)
		Kelch	387..433	CDD:128874	14/47 (30%)
		KELCH repeat	423..466	CDD:276965	9/42 (21%)
		Kelch	435..480	CDD:128874	10/44 (23%)
		Kelch_1	469..514	CDD:279660	18/44 (41%)
		KELCH repeat	470..514	CDD:276965	17/43 (40%)
		Kelch_1	517..560	CDD:279660
		KELCH repeat	517..560	CDD:276965
KLHL38	NP_001075144.2	BTB	24..128	CDD:279045	35/105 (33%)
		PHA03098	30..560	CDD:222983	150/539 (28%)
		BACK	136..237	CDD:285009	28/105 (27%)
		Kelch_6	281..321	CDD:290672	6/39 (15%)
		Kelch 1	285..332		5/46 (11%)
		KELCH repeat	325..369	CDD:276965	13/43 (30%)
		Kelch	334..383	CDD:128874	15/48 (31%)
		Kelch 2	334..383		15/48 (31%)
		Kelch_1	372..418	CDD:279660	10/45 (22%)
		KELCH repeat	373..417	CDD:276965	10/43 (23%)
		Kelch 3	384..431		12/46 (26%)
		KELCH repeat	421..508	CDD:276965	23/92 (25%)
		Kelch 4	433..479		14/46 (30%)
		Kelch	480..521	CDD:128874	10/45 (22%)
		Kelch 5	480..521		10/45 (22%)
		Kelch_1	510..560	CDD:279660	18/44 (41%)
		KELCH repeat	511..561	CDD:276965	17/43 (40%)
		Kelch 6	523..573		14/31 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910