Protein Alignment KLHL18 and klhl17

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: XP_021329356.1
• Gene: klhl17 / 336187
• ZFINID: ZDB-GENE-030131-8131
• Length: 591
• Species: Danio rerio
• Alignment Length: 575
• Identity: 250/575 - (43%)
• Similarity: 354/575 - (61%)
• Gaps: 20/575 - (3%)

  Fly     3 LSDNSQVEDQYFVYKHDKLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAM 67
            :|.||:        :|   :.:||.....:|:.|.|||:.|.|.::...||:||||:..|||:||
Zfish    16 ISHNSK--------RH---YHDSFVSMNRMRQRGLLCDIVLHVANKEIKAHKVVLASCSPYFHAM 69

  Fly    68 FTNNMAESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACAS 132
            |||.|:|||...:|:.:  |:|.|||.|:.|.|:.::.:...|||.|:..||.|||:.|||||..
Zfish    70 FTNEMSESRQTHVTLHD--IDPQALEQLVQYAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCK 132

  Fly   133 FLISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELN 197
            ||:|:..|.|.||||.|||:..|..|:.:|.||:.|:|.:||::|||:.|..:|:|:|:..|.||
Zfish   133 FLLSQLDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDNLN 197

  Fly   198 VRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDE 262
            |.:||.::.|.:.|||:..|.|.:..|:::..||||||:..||...|..|.|:|...:|:|||.|
Zfish   198 VPSEEEVYRAVLSWVKHDIDGRRQHVPRLMKCVRLPLLTRDFLMSNVDTELLVRHHSECKDLLIE 262

  Fly   263 AKDFHLMPERRGLLQSFRTRQRSGEFFTGQIYAVGG---LASTGESVSTVEIYDPLTKKWKMGEQ 324
            |..:|||||:||:|.:.|||.|..|..:..::||||   .|..|:    .|.||..|.:|.|...
Zfish   263 ALKYHLMPEQRGVLSNSRTRPRRCEGASPVLFAVGGGSLFAIHGD----CEAYDTRTDRWHMVAS 323

  Fly   325 MSMMRSRVGVAVLNGKLYAFGGFNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIY 389
            ||..|:|||||.:..||||.||::||..|:|||.|||..|.|....:|..:||.:|||.|...:|
Zfish   324 MSTRRARVGVAAIGNKLYAVGGYDGTSDLATVESYDPVTNAWQPEVSMGTRRSCLGVAVLHGLLY 388

  Fly   390 VCGGYDGVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYD 454
            ..|||||.:.||:.|.|.|.::||.::|.|...|....|..|:|.:||:||:|..|...:||:||
Zfish   389 AAGGYDGASCLNSAERYDPLTSTWTSIAAMSTRRRYVRVATLDGSLYAVGGYDSSSHLATVEKYD 453

  Fly   455 QAEDVWVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKRSR 519
            ...:.|..::.||:||...|||.|.|.:||.||..|.|.|.|||.|:|:|:||:.|.|||.:||.
Zfish   454 PQSNAWTAIANMLSRRSSAGVAVLEGMLYVAGGNDGTSCLNSVERYNPKTNTWEGVAPMNIRRST 518

  Fly   520 VALAANMGKLWAIGGYDGESNLSTVEVYDPETDKWTFMPPMCAHSGGVGAGVIRI 574
            ..|.|..|.|:|:||.||.|:|:::|.|:|.::||.....|......||..|:.:
Zfish   519 HDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRSNKWVAASCMFTRRSSVGVAVLEL 573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	52/116 (45%)
		PHA03098	36..510	CDD:222983	217/476 (46%)
		KELCH repeat	329..372	CDD:276965	23/42 (55%)
		KELCH repeat	376..417	CDD:276965	19/40 (48%)
		KELCH repeat	423..466	CDD:276965	15/42 (36%)
		KELCH repeat	470..514	CDD:276965	23/43 (53%)
		Kelch_1	517..560	CDD:396078	18/42 (43%)
		KELCH repeat	517..560	CDD:276965	18/42 (43%)
klhl17	XP_021329356.1	BTB_POZ_KLHL17_actinfilin	2..140	CDD:349555	57/136 (42%)
		PHA03098	41..507	CDD:222983	214/471 (45%)
		KELCH repeat	328..371	CDD:276965	23/42 (55%)
		KELCH repeat	375..418	CDD:276965	20/42 (48%)
		KELCH repeat	422..466	CDD:276965	15/43 (35%)
		KELCH repeat	469..513	CDD:276965	23/43 (53%)
		KELCH repeat	516..561	CDD:276965	19/44 (43%)
		Kelch	528..572	CDD:128874	17/43 (40%)