Protein Alignment KLHL18 and klhl10

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_001015100.2
• Gene: klhl10 / 3354863
• FlyBaseID: FBgn0040038
• Length: 767
• Species: Drosophila melanogaster
• Alignment Length: 558
• Identity: 161/558 - (28%)
• Similarity: 253/558 - (45%)
• Gaps: 41/558 - (7%)

  Fly    24 ESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESR--IKEITMKES- 85
            |:.....|:|....|||..:.|.:..|:.||.::.:...||.|.||...|::.  :.....|::
  Fly    67 EALNTLNELREQNLLCDAQISVGEDVFNVHRAIMCSCSSYFRAQFTGFNADTPGCVDGSDAKKNN 131

  Fly    86 ------AIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVL 144
                  .:....:..:|.|.|..|..|...||..|::.|.::.:..:...|..:|.....|.|.:
  Fly   132 NFIHIPGVSSCIMNCVIQYAYLRQTNISESNVHELLICADYVGMVGLVKKCKDYLGRILTPENCV 196

  Fly   145 GIRTFADSMICRQLIDAADKYIDQNFAKVS-QSEEFLALDCEQLLELMRRDELNVRTEEVIFEAC 208
            .|..||.......|...|..|..:.|.:|: ::.:.|.:..|....::..||||.|.|:.:::.|
  Fly   197 SIMGFARFRFLEDLHLKARNYTLRYFTEVAYRNIDILDMSAEDFYSIISDDELNTREEDHVWKLC 261

  Fly   209 MKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDF-----HL 268
            :||:....:.|......::..|||.|::|:...:.|.....:......:.|:.:...|     .|
  Fly   262 VKWIDRNPESRKRHVAHLMTGVRLGLMTPKCFMEEVKEHPYVLECEAAKPLIVDTFKFMYDLDFL 326

  Fly   269 MPERRGLLQSFRTRQRSGEFFTGQ----------IYAVGGLASTGESVSTVEIYDPLTKKWKM-- 321
            .|:             :.|..|..          |:|:||. |.|.|...:|.||....:|..
  Fly   327 NPQ-------------ADELTTPPLAMPRLPHEVIFAIGGW-SGGTSKGCIETYDTRADRWVTIN 377

  Fly   322 GEQMSMMRSRVGVAVLNGKLYAFGGFNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDD 386
            .|..:..|:..|.|||..|:::.||::|.|..:|..|:|..|.||::...|.|:|..|.|..|:.
  Fly   378 AEDPAGPRAYHGTAVLGFKIFSIGGYDGVEYFNTCRVFDAVKKKWNEIAPMHCRRCYVSVTELNG 442

  Fly   387 CIYVCGGYDGVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVE 451
            .||..|||||...|||||.|.|::|.|..:..|...||......|...:||.||.:|....||.|
  Fly   443 MIYAIGGYDGHNRLNTVERYNPRTNQWSVIPPMNMQRSDASACTLQERIYATGGFNGQECLDSAE 507

  Fly   452 RYDQAEDVWVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCK 516
            .||...:||.::..|.:||..:.......::||.||:.|.:.|.:.|.:||.|.||..:..||..
  Fly   508 YYDPVTNVWTRIPNMNHRRSGVSCVAFRNQLYVIGGFNGTARLSTGERFDPDTQTWHFIREMNHS 572

  Fly   517 RSRVALAANMGKLWAIGGYDGESNLSTVEVYDPETDKW 554
            ||...|......::||||::|.|.:|..|.|..|||:|
  Fly   573 RSNFGLEIIDDMIFAIGGFNGVSTISHTECYVAETDEW 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	28/121 (23%)
		PHA03098	36..510	CDD:222983	140/500 (28%)
		KELCH repeat	329..372	CDD:276965	16/42 (38%)
		KELCH repeat	376..417	CDD:276965	20/40 (50%)
		KELCH repeat	423..466	CDD:276965	15/42 (36%)
		KELCH repeat	470..514	CDD:276965	13/43 (30%)
		Kelch_1	517..560	CDD:396078	16/38 (42%)
		KELCH repeat	517..560	CDD:276965	16/38 (42%)
klhl10	NP_001015100.2	BTB_POZ	62..>108	CDD:453885	11/40 (28%)
		PHA03098	86..610	CDD:222983	154/537 (29%)
		KELCH repeat	385..428	CDD:276965	16/42 (38%)
		KELCH repeat	432..475	CDD:276965	20/42 (48%)
		KELCH repeat	479..523	CDD:276965	15/43 (35%)
		KELCH repeat	526..571	CDD:276965	14/44 (32%)
		KELCH repeat	573..617	CDD:276965	16/38 (42%)