Protein Alignment KLHL18 and CG1812

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_608397.1
• Gene: CG1812 / 33049
• FlyBaseID: FBgn0031119
• Length: 616
• Species: Drosophila melanogaster
• Alignment Length: 583
• Identity: 140/583 - (24%)
• Similarity: 248/583 - (42%)
• Gaps: 109/583 - (18%)

  Fly    31 EIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTN-NMAESRIKEITMKESAIEPSALES 94
            ::|...||.||||.||:..|.||||||||:..||.|||.: .|.|||..||.:  ..|:..|:.|
  Fly    40 KLRNEEKLTDVTLIVEEHRFKAHRVVLAASSDYFCAMFADCAMIESRKDEINL--YGIKARAMGS 102

  Fly    95 LINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLI 159
            :|:|:|:..:.::..|::.::..|:.:|:..|.|.|..||.::....|.|.|...||......|.
  Fly   103 IIDYIYTSMLELNYDNIEEILAAATHVQVREVIDRCTIFLGAKIEMENCLAIAGMADIYGIMDLS 167

  Fly   160 DAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRD-ELNVRTEEVIFEACMKWVKYAEDKRSELF 223
            :.|.:|:..:|.:.:.:.:|..:..:||..::..: .::|..::::...|    .:|.:::
  Fly   168 ERAYRYMCAHFEEFATTSDFKEMKVDQLRFILSSNYPIDVAEQDLVRLVC----SFAIEQQ---- 224

  Fly   224 PQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLLQSFRTRQRSGEF 288
                       |:...|.|.:   .||:..|.....:||.::.:...::
  Fly   225 -----------LNESALGDLL---RLIKWQHISYKSVDELRNMNCSLDK---------------- 259

  Fly   289 FTGQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGK------------- 340
                          |:.:.....|....|:..||..::      ||..|..:
  Fly   260 --------------GKQLPLPTSYYNRIKQEHMGHLLN------GVVSLKDQSLPQGPTNMRGME 304

  Fly   341 --LYAFGGFNGTERLSTVEVYDPRKNKWSQGCAM----LCKRSAVGVAALDDCIYVCGGYDGVTS 399
              |...|||......:.:..:.|:|..|.:..|:    .|.   .|.|.|::.:::.||...|..
  Fly   305 LCLLKIGGFEWNGLTNVIMCFSPKKMNWYELTAIPHIDQCN---FGTAVLNNKLFIVGGAYDVFL 366

  Fly   400 LNTVE----VYYPKSNTWKTVAQMMKYR---SAGGV-TQLNGYVYALGG------HDGLSIFDSV 450
            ...:.    .|.|..|||.|:|.:.:.|   |...| ||   ::||:||      .:.|.:..:|
  Fly   367 KEYIHPFGFCYCPLRNTWMTIAPIQQDRCRFSLNAVGTQ---HLYAVGGILDDDNEEALRMISNV 428

  Fly   451 ERYDQAEDVWVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNC 515
            ||||.|::||..|..:...|.:.....:..|:|:.||....:.|.|:..:|.:|:.|:.:..|..
  Fly   429 ERYDIAKNVWTYMPSLQENRSQHAGVVVGDKLYISGGVHLANILASMWVFDTKTEVWQELASMPT 493

  Fly   516 KRSRVALAANMGKLWAIGGY-----DGESNLSTVEVYDPETDKW---TFMPPMCAHSGGVGAG 570
            ......|.|...:::|.||:     :....:..:..||.||:.|   |.:|....::|....|
  Fly   494 PCCDHVLVAVDNRIYACGGWHESLTEWRVLVEHIYAYDIETNTWSVETKIPAPKFYTGVTAMG 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	43/106 (41%)
		PHA03098	36..510	CDD:222983	124/508 (24%)
		KELCH repeat	329..372	CDD:276965	10/57 (18%)
		KELCH repeat	376..417	CDD:276965	12/44 (27%)
		KELCH repeat	423..466	CDD:276965	19/52 (37%)
		KELCH repeat	470..514	CDD:276965	10/43 (23%)
		Kelch_1	517..560	CDD:396078	12/50 (24%)
		KELCH repeat	517..560	CDD:276965	12/50 (24%)
CG1812	NP_608397.1	BTB_POZ	33..151	CDD:453885	43/112 (38%)
		PHA03098	46..588	CDD:222983	139/577 (24%)
		KELCH repeat	344..390	CDD:276965	14/48 (29%)
		KELCH repeat	394..444	CDD:276965	19/52 (37%)
		KELCH repeat	448..492	CDD:276965	10/43 (23%)
		KELCH repeat	495..539	CDD:276965	10/43 (23%)